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Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study.
Atherosclerosis. 2016 Jan; 244:79-85.A

Abstract

OBJECTIVE

Lower heart rate variability (HRV) is associated with the inflammation that is linked with the progression of atherosclerosis. We examined this association, taking insulin sensitivity into consideration, as it is related to both HRV and inflammation.

METHODS

Subjects were 1728 individuals ages 30-79 years who did not smoke between 2009 and 2012. C-reactive protein (CRP) concentrations and white blood cell (WBC) counts were assessed as markers of inflammation. The homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt's insulin sensitivity index (ISI) were calculated based on fasting and 2h-post-load glucose and insulin concentrations in a 75-g oral glucose tolerance test. Pulse was recorded for 5 min, and time-domain HRV indices of standard deviation of NN intervals (SDNN) and root mean square of successive differences (RMSSD) were calculated. Power spectral analysis provided frequency domain measures of HRV: high frequency (HF) power, low frequency (LF) power and LF/HF.

RESULTS

Sex and age-adjusted logistic models presented quartiles of SDNN, RMSSD, LF, and HF significantly associated with the highest quartile of CRP or WBC. After adjustment for body mass index and ISI, the associations were attenuated for WBC; however, even after further adjustment for several variables, SDNN, RMSSD, LF, and HF remained significantly associated with elevated CRP concentrations. When results were stratified by weight, the associations appeared more evident among non-overweight individuals.

CONCLUSION

Lowered HRV, primarily due to parasympathetic dysfunction, was associated with elevated inflammation, independent of weight, insulin sensitivity, and other related factors.

Authors+Show Affiliations

Department of Community Health Systems Nursing, Ehime University Graduate School of Medicine, Toon, Japan. Electronic address: saitoi@m.ehime-u.ac.jp.Department of Total Medical Support Center, Ehime University Hospital, Toon, Japan.Department of Public Health, Juntendo University Graduate School of Medicine, Tokyo, Japan.Department of Public Health, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.Center for Education and Educational Research, Faculty of Education, Ehime University, Matsuyama, Japan.Department of Clinical Laboratory, Ehime University Hospital, Toon, Japan.Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.Department of Clinical Laboratory, Ehime University Hospital, Toon, Japan.Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.Department of Diabetes and Molecular Genetics, Ehime University Graduate School of Medicine, Toon, Japan.Department of Public Health, Juntendo University Graduate School of Medicine, Tokyo, Japan.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26595902

Citation

Saito, Isao, et al. "Impact of Heart Rate Variability On C-reactive Protein Concentrations in Japanese Adult Nonsmokers: the Toon Health Study." Atherosclerosis, vol. 244, 2016, pp. 79-85.
Saito I, Hitsumoto S, Maruyama K, et al. Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study. Atherosclerosis. 2016;244:79-85.
Saito, I., Hitsumoto, S., Maruyama, K., Eguchi, E., Kato, T., Okamoto, A., Kawamura, R., Takata, Y., Nishida, W., Nishimiya, T., Onuma, H., Osawa, H., & Tanigawa, T. (2016). Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study. Atherosclerosis, 244, 79-85. https://doi.org/10.1016/j.atherosclerosis.2015.10.112
Saito I, et al. Impact of Heart Rate Variability On C-reactive Protein Concentrations in Japanese Adult Nonsmokers: the Toon Health Study. Atherosclerosis. 2016;244:79-85. PubMed PMID: 26595902.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of heart rate variability on C-reactive protein concentrations in Japanese adult nonsmokers: The Toon Health Study. AU - Saito,Isao, AU - Hitsumoto,Shinich, AU - Maruyama,Koutatsu, AU - Eguchi,Eri, AU - Kato,Tadahiro, AU - Okamoto,Ai, AU - Kawamura,Ryoichi, AU - Takata,Yasunori, AU - Nishida,Wataru, AU - Nishimiya,Tatsuya, AU - Onuma,Hiroshi, AU - Osawa,Haruhiko, AU - Tanigawa,Takeshi, Y1 - 2015/11/04/ PY - 2015/09/20/received PY - 2015/10/24/revised PY - 2015/10/31/accepted PY - 2015/11/24/entrez PY - 2015/11/26/pubmed PY - 2016/10/12/medline KW - Epidemiology KW - Heart rate variability KW - Inflammation KW - Insulin sensitivity SP - 79 EP - 85 JF - Atherosclerosis JO - Atherosclerosis VL - 244 N2 - OBJECTIVE: Lower heart rate variability (HRV) is associated with the inflammation that is linked with the progression of atherosclerosis. We examined this association, taking insulin sensitivity into consideration, as it is related to both HRV and inflammation. METHODS: Subjects were 1728 individuals ages 30-79 years who did not smoke between 2009 and 2012. C-reactive protein (CRP) concentrations and white blood cell (WBC) counts were assessed as markers of inflammation. The homeostasis model assessment index for insulin resistance (HOMA-IR) and Gutt's insulin sensitivity index (ISI) were calculated based on fasting and 2h-post-load glucose and insulin concentrations in a 75-g oral glucose tolerance test. Pulse was recorded for 5 min, and time-domain HRV indices of standard deviation of NN intervals (SDNN) and root mean square of successive differences (RMSSD) were calculated. Power spectral analysis provided frequency domain measures of HRV: high frequency (HF) power, low frequency (LF) power and LF/HF. RESULTS: Sex and age-adjusted logistic models presented quartiles of SDNN, RMSSD, LF, and HF significantly associated with the highest quartile of CRP or WBC. After adjustment for body mass index and ISI, the associations were attenuated for WBC; however, even after further adjustment for several variables, SDNN, RMSSD, LF, and HF remained significantly associated with elevated CRP concentrations. When results were stratified by weight, the associations appeared more evident among non-overweight individuals. CONCLUSION: Lowered HRV, primarily due to parasympathetic dysfunction, was associated with elevated inflammation, independent of weight, insulin sensitivity, and other related factors. SN - 1879-1484 UR - https://www.unboundmedicine.com/medline/citation/26595902/Impact_of_heart_rate_variability_on_C_reactive_protein_concentrations_in_Japanese_adult_nonsmokers:_The_Toon_Health_Study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9150(15)30196-9 DB - PRIME DP - Unbound Medicine ER -