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Light- and electron-microscopic study of M. leprae-infected armadillo nerves.
Int J Lepr Other Mycobact Dis. 1989 Mar; 57(1):65-72.IJ

Abstract

Lesions in peripheral nerves of armadillos experimentally infected with Mycobacterium leprae were studied by light- and electron-microscopy. Bacilli could be found clearly inside axons of unmyelinated nerve fibers. Heavily bacillated Schwann cells were seen embracing unmyelinated axons with interrupted cytoplasmic membranes. This indicated the initiation of rupture of those cells which were responsible for the liberation of bacilli into the axons. The nerve lesions were divided into three grades according to their severity: grade I showed lesions focalized in the perineurium; grade II lesions were scattered inside nerve tissue; and in grade III lesions the nerve tissues were diffusely affected. No regressive changes, such as fibrosis or scar formation, were seen in the nerve lesions. Bacillated macrophages were not as foamy as those of human lesions, indicating that these bacillated cells were younger or more easily disrupted with a higher turnover than the cells in human lesions. This would promote the spread of lesions in armadillos, and would explain the less foamy appearance of the cells. We found bacilli inside lymphatics surrounding the nerves, substantiating the opinion that lesions spread to peripheral nerves not only by a hematogenous route but also by the lymphatics.

Authors+Show Affiliations

Research Department of Pathology, Sun Yat-Sen University of Medical Science, Guangzhou, People's Republic of China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2659702

Citation

Liu, T C., et al. "Light- and Electron-microscopic Study of M. Leprae-infected Armadillo Nerves." International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, vol. 57, no. 1, 1989, pp. 65-72.
Liu TC, Ji ZM, Skinsnes OK. Light- and electron-microscopic study of M. leprae-infected armadillo nerves. Int J Lepr Other Mycobact Dis. 1989;57(1):65-72.
Liu, T. C., Ji, Z. M., & Skinsnes, O. K. (1989). Light- and electron-microscopic study of M. leprae-infected armadillo nerves. International Journal of Leprosy and Other Mycobacterial Diseases : Official Organ of the International Leprosy Association, 57(1), 65-72.
Liu TC, Ji ZM, Skinsnes OK. Light- and Electron-microscopic Study of M. Leprae-infected Armadillo Nerves. Int J Lepr Other Mycobact Dis. 1989;57(1):65-72. PubMed PMID: 2659702.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Light- and electron-microscopic study of M. leprae-infected armadillo nerves. AU - Liu,T C, AU - Ji,Z M, AU - Skinsnes,O K, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 65 EP - 72 JF - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association JO - Int J Lepr Other Mycobact Dis VL - 57 IS - 1 N2 - Lesions in peripheral nerves of armadillos experimentally infected with Mycobacterium leprae were studied by light- and electron-microscopy. Bacilli could be found clearly inside axons of unmyelinated nerve fibers. Heavily bacillated Schwann cells were seen embracing unmyelinated axons with interrupted cytoplasmic membranes. This indicated the initiation of rupture of those cells which were responsible for the liberation of bacilli into the axons. The nerve lesions were divided into three grades according to their severity: grade I showed lesions focalized in the perineurium; grade II lesions were scattered inside nerve tissue; and in grade III lesions the nerve tissues were diffusely affected. No regressive changes, such as fibrosis or scar formation, were seen in the nerve lesions. Bacillated macrophages were not as foamy as those of human lesions, indicating that these bacillated cells were younger or more easily disrupted with a higher turnover than the cells in human lesions. This would promote the spread of lesions in armadillos, and would explain the less foamy appearance of the cells. We found bacilli inside lymphatics surrounding the nerves, substantiating the opinion that lesions spread to peripheral nerves not only by a hematogenous route but also by the lymphatics. SN - 0148-916X UR - https://www.unboundmedicine.com/medline/citation/2659702/Light__and_electron_microscopic_study_of_M__leprae_infected_armadillo_nerves_ L2 - https://medlineplus.gov/mycobacterialinfections.html DB - PRIME DP - Unbound Medicine ER -