Tags

Type your tag names separated by a space and hit enter

Acid-Base Homeostasis.
Clin J Am Soc Nephrol. 2015 Dec 07; 10(12):2232-42.CJ

Abstract

Acid-base homeostasis and pH regulation are critical for both normal physiology and cell metabolism and function. The importance of this regulation is evidenced by a variety of physiologic derangements that occur when plasma pH is either high or low. The kidneys have the predominant role in regulating the systemic bicarbonate concentration and hence, the metabolic component of acid-base balance. This function of the kidneys has two components: reabsorption of virtually all of the filtered HCO3(-) and production of new bicarbonate to replace that consumed by normal or pathologic acids. This production or generation of new HCO3(-) is done by net acid excretion. Under normal conditions, approximately one-third to one-half of net acid excretion by the kidneys is in the form of titratable acid. The other one-half to two-thirds is the excretion of ammonium. The capacity to excrete ammonium under conditions of acid loads is quantitatively much greater than the capacity to increase titratable acid. Multiple, often redundant pathways and processes exist to regulate these renal functions. Derangements in acid-base homeostasis, however, are common in clinical medicine and can often be related to the systems involved in acid-base transport in the kidneys.

Authors+Show Affiliations

Department of Medicine, Section of Nephrology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana; and Medicine Service, Southeast Louisiana Veterans Health Care System, New Orleans, Louisiana Lhamm@tulane.edu.Department of Medicine, Section of Nephrology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana; and Medicine Service, Southeast Louisiana Veterans Health Care System, New Orleans, Louisiana.Department of Medicine, Section of Nephrology, Tulane Hypertension and Renal Center of Excellence, Tulane University School of Medicine, New Orleans, Louisiana; and Medicine Service, Southeast Louisiana Veterans Health Care System, New Orleans, Louisiana.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26597304

Citation

Hamm, L Lee, et al. "Acid-Base Homeostasis." Clinical Journal of the American Society of Nephrology : CJASN, vol. 10, no. 12, 2015, pp. 2232-42.
Hamm LL, Nakhoul N, Hering-Smith KS. Acid-Base Homeostasis. Clin J Am Soc Nephrol. 2015;10(12):2232-42.
Hamm, L. L., Nakhoul, N., & Hering-Smith, K. S. (2015). Acid-Base Homeostasis. Clinical Journal of the American Society of Nephrology : CJASN, 10(12), 2232-42. https://doi.org/10.2215/CJN.07400715
Hamm LL, Nakhoul N, Hering-Smith KS. Acid-Base Homeostasis. Clin J Am Soc Nephrol. 2015 Dec 7;10(12):2232-42. PubMed PMID: 26597304.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Acid-Base Homeostasis. AU - Hamm,L Lee, AU - Nakhoul,Nazih, AU - Hering-Smith,Kathleen S, Y1 - 2015/11/23/ PY - 2015/11/25/entrez PY - 2015/11/26/pubmed PY - 2016/9/14/medline KW - acid-base equilibrium KW - acid-base homeostasis KW - acidosis KW - bone density KW - chronic KW - homeostasis KW - kidney KW - nephrolithiasis KW - pH regulation KW - renal insufficiency KW - renal physiology SP - 2232 EP - 42 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 10 IS - 12 N2 - Acid-base homeostasis and pH regulation are critical for both normal physiology and cell metabolism and function. The importance of this regulation is evidenced by a variety of physiologic derangements that occur when plasma pH is either high or low. The kidneys have the predominant role in regulating the systemic bicarbonate concentration and hence, the metabolic component of acid-base balance. This function of the kidneys has two components: reabsorption of virtually all of the filtered HCO3(-) and production of new bicarbonate to replace that consumed by normal or pathologic acids. This production or generation of new HCO3(-) is done by net acid excretion. Under normal conditions, approximately one-third to one-half of net acid excretion by the kidneys is in the form of titratable acid. The other one-half to two-thirds is the excretion of ammonium. The capacity to excrete ammonium under conditions of acid loads is quantitatively much greater than the capacity to increase titratable acid. Multiple, often redundant pathways and processes exist to regulate these renal functions. Derangements in acid-base homeostasis, however, are common in clinical medicine and can often be related to the systems involved in acid-base transport in the kidneys. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/26597304/Acid_Base_Homeostasis_ L2 - https://cjasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=26597304 DB - PRIME DP - Unbound Medicine ER -