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Essential oil of Algerian Eucalyptus citriodora: Chemical composition, antifungal activity.
J Mycol Med. 2015 Dec; 25(4):e128-33.JM

Abstract

OBJECTIVE

Essential oil of Eucalyptus citriodora is a natural product which has been attributed for various medicinal uses. In the present investigation, E. citriodora essential oil was used to evaluate its antifungal effect against medically important dermatophytes.

MATERIAL AND METHODS

Essential oil from the Algerian E. citriodora leaves was analyzed by GC and GC/MS. The antifungal effect of E. citriodora essential oil was evaluated against four dermatophytes: Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum using disc diffusion method, disc volatilization method, and agar dilution method.

RESULTS

The chemical composition of the oil revealed the presence of 22 compounds accounting for 95.27% of the oil. The dominant compounds were citronellal (69.77%), citronellol (10.63%) and isopulegol (4.66%). The disc diffusion method, MIC and MFC determination, indicated that E. citriodora essential oil had a higher antifungal potential against the tested strains with inhibition zone diameter which varied from (12 to 90mm) and MIC and MFC values ranged from (0.6 to 5μL/mL and 1.25 to 5μL/mL) respectively. The M. gypseum was the most resistant to the oil.

CONCLUSION

The results of the present study indicated that E. citriodora essential oil may be used as a new antifungal agent recommended by the pharmaceutical industries.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Tolba H
Laboratory of reaction engineering, department of process engineering, faculty of mechanical engineering and process engineering, USTHB, PO Box 32 El Alia, Bab Ezzouar, 16111 Algiers, Algeria. Electronic address: htolba@usthb.dz.
Moghrani H
Laboratory of reaction engineering, department of process engineering, faculty of mechanical engineering and process engineering, USTHB, PO Box 32 El Alia, Bab Ezzouar, 16111 Algiers, Algeria.
Benelmouffok A
Laboratory of Mycology, Pasteur Institute, Algiers, Algeria.
Kellou D
Laboratory of Mycology, Pasteur Institute, Algiers, Algeria.
Maachi R
Laboratory of reaction engineering, department of process engineering, faculty of mechanical engineering and process engineering, USTHB, PO Box 32 El Alia, Bab Ezzouar, 16111 Algiers, Algeria.

MeSH

Acyclic MonoterpenesAldehydesAlgeriaAntifungal AgentsArthrodermataceaeCyclohexane MonoterpenesEucalyptusGas Chromatography-Mass SpectrometryMicrobial Sensitivity TestsMonoterpenesOils, VolatilePlant LeavesPlant OilsTerpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26597375

Citation

Tolba, H, et al. "Essential Oil of Algerian Eucalyptus Citriodora: Chemical Composition, Antifungal Activity." Journal De Mycologie Medicale, vol. 25, no. 4, 2015, pp. e128-33.
Tolba H, Moghrani H, Benelmouffok A, et al. Essential oil of Algerian Eucalyptus citriodora: Chemical composition, antifungal activity. J Mycol Med. 2015;25(4):e128-33.
Tolba, H., Moghrani, H., Benelmouffok, A., Kellou, D., & Maachi, R. (2015). Essential oil of Algerian Eucalyptus citriodora: Chemical composition, antifungal activity. Journal De Mycologie Medicale, 25(4), e128-33. https://doi.org/10.1016/j.mycmed.2015.10.009
Tolba H, et al. Essential Oil of Algerian Eucalyptus Citriodora: Chemical Composition, Antifungal Activity. J Mycol Med. 2015;25(4):e128-33. PubMed PMID: 26597375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Essential oil of Algerian Eucalyptus citriodora: Chemical composition, antifungal activity. AU - Tolba,H, AU - Moghrani,H, AU - Benelmouffok,A, AU - Kellou,D, AU - Maachi,R, Y1 - 2015/12/01/ PY - 2015/04/13/received PY - 2015/10/11/revised PY - 2015/10/12/accepted PY - 2015/11/25/entrez PY - 2015/11/26/pubmed PY - 2016/12/15/medline KW - Activité antifongique KW - Antifungal activity KW - Composition chimique KW - Dermatophytes KW - Essential oil KW - Eucalyptus Citriodora KW - Huile essentielle SP - e128 EP - 33 JF - Journal de mycologie medicale JO - J Mycol Med VL - 25 IS - 4 N2 - OBJECTIVE: Essential oil of Eucalyptus citriodora is a natural product which has been attributed for various medicinal uses. In the present investigation, E. citriodora essential oil was used to evaluate its antifungal effect against medically important dermatophytes. MATERIAL AND METHODS: Essential oil from the Algerian E. citriodora leaves was analyzed by GC and GC/MS. The antifungal effect of E. citriodora essential oil was evaluated against four dermatophytes: Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, Trichophyton rubrum using disc diffusion method, disc volatilization method, and agar dilution method. RESULTS: The chemical composition of the oil revealed the presence of 22 compounds accounting for 95.27% of the oil. The dominant compounds were citronellal (69.77%), citronellol (10.63%) and isopulegol (4.66%). The disc diffusion method, MIC and MFC determination, indicated that E. citriodora essential oil had a higher antifungal potential against the tested strains with inhibition zone diameter which varied from (12 to 90mm) and MIC and MFC values ranged from (0.6 to 5μL/mL and 1.25 to 5μL/mL) respectively. The M. gypseum was the most resistant to the oil. CONCLUSION: The results of the present study indicated that E. citriodora essential oil may be used as a new antifungal agent recommended by the pharmaceutical industries. SN - 1773-0449 UR - https://www.unboundmedicine.com/medline/citation/26597375/Essential_oil_of_Algerian_Eucalyptus_citriodora:_Chemical_composition_antifungal_activity_ DB - PRIME DP - Unbound Medicine ER -