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A low vitamin D status at diagnosis is associated with an early conversion to secondary progressive multiple sclerosis.
J Steroid Biochem Mol Biol 2016; 164:254-257JS

Abstract

Low circulating 25-hydroxyvitamin D (25(OH)D) levels have been associated with an increased risk of relapses in relapsing remitting multiple sclerosis (RRMS), but an association with disability progression is uncertain. Lower 25(OH)D levels are found in secondary progressive MS (SPMS) when compared to RRMS. We hypothesized that a poor vitamin D status in RRMS is associated with an increased risk of conversion to SPMS. In a retrospective longitudinal study we measured 25(OH)D levels at the start of a 3-year follow-up, and analyzed whether these levels predict the risk of RRMS to SPMS conversion. In 338 RRMS patients, vitamin D status did not predict the 3-year risk of conversion to SPMS (n=51; OR 0.970; p=0.65). However, in diagnostic blood samples of SPMS patients with a relatively short RRMS duration (n=19) 25(OH)D levels were significantly lower (38nmol/L; Q1-Q3: 24-50) than in diagnostic samples of matched RRMS patients with no progression to SPMS ((n=38; 55nmol/L; Q1-Q3: 40-70) (p<0.01). These data indicate an association between a low vitamin D status at the start of RRMS and the early conversion to SPMS. Therefore, time to SPMS conversion is of interest as clinical measure in (follow-up of) clinical vitamin D supplementation studies.

Authors+Show Affiliations

School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands. Electronic address: a.muris@maastrichtuniversity.nl.School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands.Clinical Chemistry, Zuyderland Medical Center, Sittard, The Netherlands.School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands; Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands.Central Diagnostic Laboratory, Maastricht University Medical Center, Maastricht, The Netherlands.Academic MS Center Limburg, Zuyderland Medical Center, Sittard, The Netherlands; Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26598277

Citation

Muris, Anne-Hilde, et al. "A Low Vitamin D Status at Diagnosis Is Associated With an Early Conversion to Secondary Progressive Multiple Sclerosis." The Journal of Steroid Biochemistry and Molecular Biology, vol. 164, 2016, pp. 254-257.
Muris AH, Rolf L, Broen K, et al. A low vitamin D status at diagnosis is associated with an early conversion to secondary progressive multiple sclerosis. J Steroid Biochem Mol Biol. 2016;164:254-257.
Muris, A. H., Rolf, L., Broen, K., Hupperts, R., Damoiseaux, J., & Smolders, J. (2016). A low vitamin D status at diagnosis is associated with an early conversion to secondary progressive multiple sclerosis. The Journal of Steroid Biochemistry and Molecular Biology, 164, pp. 254-257. doi:10.1016/j.jsbmb.2015.11.009.
Muris AH, et al. A Low Vitamin D Status at Diagnosis Is Associated With an Early Conversion to Secondary Progressive Multiple Sclerosis. J Steroid Biochem Mol Biol. 2016;164:254-257. PubMed PMID: 26598277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A low vitamin D status at diagnosis is associated with an early conversion to secondary progressive multiple sclerosis. AU - Muris,Anne-Hilde, AU - Rolf,Linda, AU - Broen,Kelly, AU - Hupperts,Raymond, AU - Damoiseaux,Jan, AU - Smolders,Joost, Y1 - 2015/11/17/ PY - 2015/06/15/received PY - 2015/10/30/revised PY - 2015/11/12/accepted PY - 2015/11/26/pubmed PY - 2017/6/15/medline PY - 2015/11/25/entrez KW - 25-Hydroxyvitamin D KW - Disability KW - Relapsing remitting multiple sclerosis KW - Secondary progressive multiple sclerosis KW - Vitamin D SP - 254 EP - 257 JF - The Journal of steroid biochemistry and molecular biology JO - J. Steroid Biochem. Mol. Biol. VL - 164 N2 - Low circulating 25-hydroxyvitamin D (25(OH)D) levels have been associated with an increased risk of relapses in relapsing remitting multiple sclerosis (RRMS), but an association with disability progression is uncertain. Lower 25(OH)D levels are found in secondary progressive MS (SPMS) when compared to RRMS. We hypothesized that a poor vitamin D status in RRMS is associated with an increased risk of conversion to SPMS. In a retrospective longitudinal study we measured 25(OH)D levels at the start of a 3-year follow-up, and analyzed whether these levels predict the risk of RRMS to SPMS conversion. In 338 RRMS patients, vitamin D status did not predict the 3-year risk of conversion to SPMS (n=51; OR 0.970; p=0.65). However, in diagnostic blood samples of SPMS patients with a relatively short RRMS duration (n=19) 25(OH)D levels were significantly lower (38nmol/L; Q1-Q3: 24-50) than in diagnostic samples of matched RRMS patients with no progression to SPMS ((n=38; 55nmol/L; Q1-Q3: 40-70) (p<0.01). These data indicate an association between a low vitamin D status at the start of RRMS and the early conversion to SPMS. Therefore, time to SPMS conversion is of interest as clinical measure in (follow-up of) clinical vitamin D supplementation studies. SN - 1879-1220 UR - https://www.unboundmedicine.com/medline/citation/26598277/A_low_vitamin_D_status_at_diagnosis_is_associated_with_an_early_conversion_to_secondary_progressive_multiple_sclerosis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0960-0760(15)30136-9 DB - PRIME DP - Unbound Medicine ER -