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Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril.
Indian J Pharmacol. 2015 Sep-Oct; 47(5):540-5.IJ

Abstract

OBJECTIVES

The present study investigated the effects of aqueous extract of Hibiscus sabdariffa (HS) on the three basic components of renin-angiotensin-aldosterone system: Plasma renin, serum angiotensin-converting enzyme (ACE), and plasma aldosterone (PA) in mild to moderate essential hypertensive Nigerians and compared with that of lisinopril, an ACE inhibitor.

MATERIALS AND METHODS

A double-blind controlled randomized clinical study was used. Seventy-eight newly diagnosed but untreated mild to moderate hypertensive subjects attending Medical Outpatients Clinic of Enugu State University Teaching Hospital, Enugu were recruited for the study. Those in Group A received placebo (150 mg/kg/day), Group B were given lisinopril (10 mg once daily) while those in Group C received aqueous extract of HS (150 mg/kg/day). After 4 weeks of treatment, the levels of plasma renin, serum ACE, and PA were determined.

RESULTS

HS and lisinopril significantly (P < 0.001) reduced PA compared to placebo by 32.06% and 30.01%, respectively. Their effects on serum ACE and plasma renin activity (PRA) were not significant compared to placebo; they reduced ACE by 6.63% and 5.67% but increased plasma PRA by 2.77% and 5.36%, respectively.

CONCLUSION

HS reduced serum ACE and PA in mild to moderate hypertensive Nigerians with equal efficacy as lisinopril. These actions are possibly due to the presence of anthocyanins in the extract.

Authors+Show Affiliations

Department of Physiology, College of Medicine, University of Nigeria, Enugu Campus, Enugu, Enugu State, Nigeria.Department of Medicine, Enugu State University of Science and Technology, Enugu, Enugu State, Nigeria.Department of Physiology, School of Basic Medical Sciences, University of Benin, Benin City, Edo State, Nigeria.Department of Ophthalmology, University of Nigeria Teaching Hospital, Enugu, Enugu State, Nigeria.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26600645

Citation

Nwachukwu, Daniel Chukwu, et al. "Effects of Aqueous Extract of Hibiscus Sabdariffa On the Renin-angiotensin-aldosterone System of Nigerians With Mild to Moderate Essential Hypertension: a Comparative Study With Lisinopril." Indian Journal of Pharmacology, vol. 47, no. 5, 2015, pp. 540-5.
Nwachukwu DC, Aneke EI, Obika LF, et al. Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril. Indian J Pharmacol. 2015;47(5):540-5.
Nwachukwu, D. C., Aneke, E. I., Obika, L. F., & Nwachukwu, N. Z. (2015). Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril. Indian Journal of Pharmacology, 47(5), 540-5. https://doi.org/10.4103/0253-7613.165194
Nwachukwu DC, et al. Effects of Aqueous Extract of Hibiscus Sabdariffa On the Renin-angiotensin-aldosterone System of Nigerians With Mild to Moderate Essential Hypertension: a Comparative Study With Lisinopril. Indian J Pharmacol. 2015;47(5):540-5. PubMed PMID: 26600645.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of aqueous extract of Hibiscus sabdariffa on the renin-angiotensin-aldosterone system of Nigerians with mild to moderate essential hypertension: A comparative study with lisinopril. AU - Nwachukwu,Daniel Chukwu, AU - Aneke,Eddy Ikemefuna, AU - Obika,Leonard Fidelis, AU - Nwachukwu,Nkiru Zuada, PY - 2015/11/25/entrez PY - 2015/11/26/pubmed PY - 2016/6/18/medline KW - Aldosterone and essential hypertension KW - Hibiscus sabdariffa KW - angiotensin-converting enzyme KW - lisinopril KW - renin SP - 540 EP - 5 JF - Indian journal of pharmacology JO - Indian J Pharmacol VL - 47 IS - 5 N2 - OBJECTIVES: The present study investigated the effects of aqueous extract of Hibiscus sabdariffa (HS) on the three basic components of renin-angiotensin-aldosterone system: Plasma renin, serum angiotensin-converting enzyme (ACE), and plasma aldosterone (PA) in mild to moderate essential hypertensive Nigerians and compared with that of lisinopril, an ACE inhibitor. MATERIALS AND METHODS: A double-blind controlled randomized clinical study was used. Seventy-eight newly diagnosed but untreated mild to moderate hypertensive subjects attending Medical Outpatients Clinic of Enugu State University Teaching Hospital, Enugu were recruited for the study. Those in Group A received placebo (150 mg/kg/day), Group B were given lisinopril (10 mg once daily) while those in Group C received aqueous extract of HS (150 mg/kg/day). After 4 weeks of treatment, the levels of plasma renin, serum ACE, and PA were determined. RESULTS: HS and lisinopril significantly (P < 0.001) reduced PA compared to placebo by 32.06% and 30.01%, respectively. Their effects on serum ACE and plasma renin activity (PRA) were not significant compared to placebo; they reduced ACE by 6.63% and 5.67% but increased plasma PRA by 2.77% and 5.36%, respectively. CONCLUSION: HS reduced serum ACE and PA in mild to moderate hypertensive Nigerians with equal efficacy as lisinopril. These actions are possibly due to the presence of anthocyanins in the extract. SN - 1998-3751 UR - https://www.unboundmedicine.com/medline/citation/26600645/Effects_of_aqueous_extract_of_Hibiscus_sabdariffa_on_the_renin_angiotensin_aldosterone_system_of_Nigerians_with_mild_to_moderate_essential_hypertension:_A_comparative_study_with_lisinopril_ L2 - http://www.ijp-online.com/article.asp?issn=0253-7613;year=2015;volume=47;issue=5;spage=540;epage=545;aulast=Nwachukwu DB - PRIME DP - Unbound Medicine ER -