Tags

Type your tag names separated by a space and hit enter

Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial.
Eur J Clin Nutr. 2016 Feb; 70(2):170-4.EJ

Abstract

BACKGROUND/OBJECTIVES

The pathogenesis of enteritis after abdominal radiotherapy (RT) is unknown, although changes in fecal microbiota may be involved. Prebiotics stimulate the proliferation of Lactobacillus spp and Bifidobacterium spp, and this may have positive effects on the intestinal mucosa during abdominal RT.

SUBJECTS/METHODS

We performed a randomized, double-blind, placebo-controlled trial involving patients with gynecological cancer who received abdominal RT after surgery. Patients were randomized to receive prebiotics or placebo. The prebiotic group received a mixture of fiber (50 inulin and 50% fructo-oligosaccharide), and the placebo group received 6 g of maltodextrin twice daily from 1 week before to 3 weeks after RT. The number of bowel movements and stool consistency was recorded daily. Diarrhea was evaluated according to the Common Toxicity Criteria of the National Cancer Institute. Stool consistency was assessed using the 7-point Bristol scale. Patients' quality-of-life was evaluated at baseline and at completion of RT using the EORTC-QLQ-C30 (European Organization for Research and Treatment of Cancer quality-of-life Questionnaire C30) test.

RESULTS

Thirty-eight women with a mean age of 60.3±11.8 years participated in the study. Both groups (prebiotic (n=20) and placebo (n=18)) were comparable in their baseline characteristics. The number of bowel movements per month increased in both groups during RT. The number of bowel movements per day increased in both groups. The number of days with watery stool (Bristol score 7) was lower in the prebiotic group (3.3±4.4 to 2.2±1.6) than in the placebo group (P=0.08). With respect to quality-of-life, the symptoms with the highest score in the placebo group were insomnia at baseline and diarrhea toward the end of the treatment. In the prebiotic group, insomnia was the symptom with the highest score at both assessments, although the differences were not statistically significant.

CONCLUSIONS

Prebiotics can improve the consistency of stools in gynecologic cancer patients on RT. This finding could have important implications in the quality-of-life of these patients during treatment.

Authors+Show Affiliations

Nutrition Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.Nutrition Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.Department of Biotechnology, Polytechnic University of Valencia, Valencia, Spain.Radiotherapy Service, Hospital General Universitario Gregorio Marañón, Madrid, Spain.Nutrition Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.Nutrition Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.Nutrition Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.Nutrition Unit, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain.Digestive System Research Unit, Hospital General Vall d' Hebron, Barcelona, Spain.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26603881

Citation

Garcia-Peris, P, et al. "Effect of Inulin and Fructo-oligosaccharide On the Prevention of Acute Radiation Enteritis in Patients With Gynecological Cancer and Impact On Quality-of-life: a Randomized, Double-blind, Placebo-controlled Trial." European Journal of Clinical Nutrition, vol. 70, no. 2, 2016, pp. 170-4.
Garcia-Peris P, Velasco C, Hernandez M, et al. Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2016;70(2):170-4.
Garcia-Peris, P., Velasco, C., Hernandez, M., Lozano, M. A., Paron, L., de la Cuerda, C., Breton, I., Camblor, M., & Guarner, F. (2016). Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial. European Journal of Clinical Nutrition, 70(2), 170-4. https://doi.org/10.1038/ejcn.2015.192
Garcia-Peris P, et al. Effect of Inulin and Fructo-oligosaccharide On the Prevention of Acute Radiation Enteritis in Patients With Gynecological Cancer and Impact On Quality-of-life: a Randomized, Double-blind, Placebo-controlled Trial. Eur J Clin Nutr. 2016;70(2):170-4. PubMed PMID: 26603881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of inulin and fructo-oligosaccharide on the prevention of acute radiation enteritis in patients with gynecological cancer and impact on quality-of-life: a randomized, double-blind, placebo-controlled trial. AU - Garcia-Peris,P, AU - Velasco,C, AU - Hernandez,M, AU - Lozano,M A, AU - Paron,L, AU - de la Cuerda,C, AU - Breton,I, AU - Camblor,M, AU - Guarner,F, Y1 - 2015/11/25/ PY - 2015/02/04/received PY - 2015/09/08/revised PY - 2015/09/24/accepted PY - 2015/11/26/entrez PY - 2015/11/26/pubmed PY - 2016/11/1/medline SP - 170 EP - 4 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 70 IS - 2 N2 - BACKGROUND/OBJECTIVES: The pathogenesis of enteritis after abdominal radiotherapy (RT) is unknown, although changes in fecal microbiota may be involved. Prebiotics stimulate the proliferation of Lactobacillus spp and Bifidobacterium spp, and this may have positive effects on the intestinal mucosa during abdominal RT. SUBJECTS/METHODS: We performed a randomized, double-blind, placebo-controlled trial involving patients with gynecological cancer who received abdominal RT after surgery. Patients were randomized to receive prebiotics or placebo. The prebiotic group received a mixture of fiber (50 inulin and 50% fructo-oligosaccharide), and the placebo group received 6 g of maltodextrin twice daily from 1 week before to 3 weeks after RT. The number of bowel movements and stool consistency was recorded daily. Diarrhea was evaluated according to the Common Toxicity Criteria of the National Cancer Institute. Stool consistency was assessed using the 7-point Bristol scale. Patients' quality-of-life was evaluated at baseline and at completion of RT using the EORTC-QLQ-C30 (European Organization for Research and Treatment of Cancer quality-of-life Questionnaire C30) test. RESULTS: Thirty-eight women with a mean age of 60.3±11.8 years participated in the study. Both groups (prebiotic (n=20) and placebo (n=18)) were comparable in their baseline characteristics. The number of bowel movements per month increased in both groups during RT. The number of bowel movements per day increased in both groups. The number of days with watery stool (Bristol score 7) was lower in the prebiotic group (3.3±4.4 to 2.2±1.6) than in the placebo group (P=0.08). With respect to quality-of-life, the symptoms with the highest score in the placebo group were insomnia at baseline and diarrhea toward the end of the treatment. In the prebiotic group, insomnia was the symptom with the highest score at both assessments, although the differences were not statistically significant. CONCLUSIONS: Prebiotics can improve the consistency of stools in gynecologic cancer patients on RT. This finding could have important implications in the quality-of-life of these patients during treatment. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/26603881/Effect_of_inulin_and_fructo_oligosaccharide_on_the_prevention_of_acute_radiation_enteritis_in_patients_with_gynecological_cancer_and_impact_on_quality_of_life:_a_randomized_double_blind_placebo_controlled_trial_ L2 - http://dx.doi.org/10.1038/ejcn.2015.192 DB - PRIME DP - Unbound Medicine ER -