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Inspiratory Muscle Strength and Endurance in Children and Adolescents with Cystic Fibrosis.
Respir Care. 2016 Feb; 61(2):184-91.RC

Abstract

BACKGROUND

Pulmonary changes that occur in cystic fibrosis may influence inspiratory muscle strength and endurance. We evaluated inspiratory muscle strength and endurance in children and adolescents with cystic fibrosis in comparison with healthy subjects.

METHODS

This is a cross-sectional observational study with subjects with cystic fibrosis and paired healthy individuals, age 6-18 y. Spirometry, impulse oscillometry, plethysmography, manovacuometry, and a protocol of inspiratory muscle endurance were performed.

RESULTS

Subjects with cystic fibrosis (n = 34) had higher maximum percent-of-predicted inspiratory pressure (PImax) than healthy (n = 68) subjects (118.5 ± 25.8% vs 105.8 ± 18.0%) and no significant difference in endurance (60.9 ± 13.3% vs 65.3 ± 12.3%). When restricting the analysis to subjects without Pseudomonas aeruginosa colonization and with FEV1 > 80%, PImax values were significantly higher, and inspiratory muscle endurance was lower, in comparison with the control group. PImax correlated significantly with FVC (r = 0.44, P = .02) and FEV1 (r = 0.41, P = .02), whereas endurance correlated better with total airway resistance (r = 0.35, P = .045) and with central airway resistance (r = 0.48, P = .004).

CONCLUSIONS

Children and adolescents with cystic fibrosis with no colonization by P. aeruginosa and normal lung function present increased inspiratory muscle strength and decreased endurance compared with healthy individuals, indicating that changes in the respiratory muscle function seem to be distinctly associated with pulmonary involvement. Strength was related to pulmonary function parameters, whereas endurance was associated with airway resistance.

Authors+Show Affiliations

Centro Infant, Institute of Biomedical Research, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.Centro Infant, Institute of Biomedical Research, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil.School of Nursing, Nutrition and Physiotherapy, PUCRS, Porto Alegre, RS, Brazil.School of Medicine, Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.Centro Infant, Institute of Biomedical Research, PUCRS, Porto Alegre, RS, Brazil. mdonadio@pucrs.br.

Pub Type(s)

Journal Article
Observational Study

Language

eng

PubMed ID

26604327

Citation

Vendrusculo, Fernanda M., et al. "Inspiratory Muscle Strength and Endurance in Children and Adolescents With Cystic Fibrosis." Respiratory Care, vol. 61, no. 2, 2016, pp. 184-91.
Vendrusculo FM, Heinzmann-Filho JP, Piva TC, et al. Inspiratory Muscle Strength and Endurance in Children and Adolescents with Cystic Fibrosis. Respir Care. 2016;61(2):184-91.
Vendrusculo, F. M., Heinzmann-Filho, J. P., Piva, T. C., Marostica, P. J., & Donadio, M. V. (2016). Inspiratory Muscle Strength and Endurance in Children and Adolescents with Cystic Fibrosis. Respiratory Care, 61(2), 184-91. https://doi.org/10.4187/respcare.04231
Vendrusculo FM, et al. Inspiratory Muscle Strength and Endurance in Children and Adolescents With Cystic Fibrosis. Respir Care. 2016;61(2):184-91. PubMed PMID: 26604327.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inspiratory Muscle Strength and Endurance in Children and Adolescents with Cystic Fibrosis. AU - Vendrusculo,Fernanda M, AU - Heinzmann-Filho,João P, AU - Piva,Taila C, AU - Marostica,Paulo J C, AU - Donadio,Márcio V F, Y1 - 2015/11/24/ PY - 2015/11/26/entrez PY - 2015/11/26/pubmed PY - 2016/12/30/medline KW - adolescent KW - child KW - cystic fibrosis KW - respiratory muscles SP - 184 EP - 91 JF - Respiratory care JO - Respir Care VL - 61 IS - 2 N2 - BACKGROUND: Pulmonary changes that occur in cystic fibrosis may influence inspiratory muscle strength and endurance. We evaluated inspiratory muscle strength and endurance in children and adolescents with cystic fibrosis in comparison with healthy subjects. METHODS: This is a cross-sectional observational study with subjects with cystic fibrosis and paired healthy individuals, age 6-18 y. Spirometry, impulse oscillometry, plethysmography, manovacuometry, and a protocol of inspiratory muscle endurance were performed. RESULTS: Subjects with cystic fibrosis (n = 34) had higher maximum percent-of-predicted inspiratory pressure (PImax) than healthy (n = 68) subjects (118.5 ± 25.8% vs 105.8 ± 18.0%) and no significant difference in endurance (60.9 ± 13.3% vs 65.3 ± 12.3%). When restricting the analysis to subjects without Pseudomonas aeruginosa colonization and with FEV1 > 80%, PImax values were significantly higher, and inspiratory muscle endurance was lower, in comparison with the control group. PImax correlated significantly with FVC (r = 0.44, P = .02) and FEV1 (r = 0.41, P = .02), whereas endurance correlated better with total airway resistance (r = 0.35, P = .045) and with central airway resistance (r = 0.48, P = .004). CONCLUSIONS: Children and adolescents with cystic fibrosis with no colonization by P. aeruginosa and normal lung function present increased inspiratory muscle strength and decreased endurance compared with healthy individuals, indicating that changes in the respiratory muscle function seem to be distinctly associated with pulmonary involvement. Strength was related to pulmonary function parameters, whereas endurance was associated with airway resistance. SN - 1943-3654 UR - https://www.unboundmedicine.com/medline/citation/26604327/Inspiratory_Muscle_Strength_and_Endurance_in_Children_and_Adolescents_with_Cystic_Fibrosis_ L2 - http://rc.rcjournal.com/cgi/pmidlookup?view=short&pmid=26604327 DB - PRIME DP - Unbound Medicine ER -