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Prophylactic use of intravenous ondansetron versus ketamine - midazolam combination for prevention of shivering during spinal anesthesia: A randomized double-blind placebo-controlled trial.
Adv Biomed Res. 2015; 4:207.AB

Abstract

BACKGROUND

The aim of this study was to compare the efficacy intravenous (IV) ondansetron with ketamine plus midazolam for the prevention of shivering during spinal anesthesia (SA).

MATERIALS AND METHODS

Ninety patients, aged 18-65 years, undergoing lower extremity orthopedic surgery were included in the present study. SA was performed in all patients with hyperbaric bupivacaine 15 mg. The patients were randomly allocated to receive normal saline (Group C), ondansetron 8 mg IV (Group O) or ketamine 0.25 mg/kg IV plus midazolam 37.5 μg/kg IV (Group KM) immediately after SA. During surgery, shivering scores were recorded at 5 min intervals. The operating room temperature was maintained at 24°C.

RESULTS

The incidences of shivering were 18 (60%) in Group C, 6 (20%) in Group KM and 8 (26.6%) in Group O. The difference between Groups O and Group KM with Group C was statistically significant (P < 0.05). No significant difference was noted between Groups KM with Group O in this regard (P > 0.05). Peripheral and core temperature changes throughout surgery were not significantly different among three groups (P > 0.05). Incidence (%) of hallucination was not significantly different between the three groups (0, 3.3, 0 in Group O, Group KM, Group C respectively, P > 0.05).

CONCLUSION

Prophylactic use of ondansetron 8 mg IV was comparable to ketamine 0.25 mg/kg IV plus midazolam 37.5 μg/kg IV in preventing shivering during SA.

Authors+Show Affiliations

Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.Anesthesiology and Critical Care Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26605236

Citation

Safavi, Mohammadreza, et al. "Prophylactic Use of Intravenous Ondansetron Versus Ketamine - Midazolam Combination for Prevention of Shivering During Spinal Anesthesia: a Randomized Double-blind Placebo-controlled Trial." Advanced Biomedical Research, vol. 4, 2015, p. 207.
Safavi M, Honarmand A, Mohammadsadeqie S. Prophylactic use of intravenous ondansetron versus ketamine - midazolam combination for prevention of shivering during spinal anesthesia: A randomized double-blind placebo-controlled trial. Adv Biomed Res. 2015;4:207.
Safavi, M., Honarmand, A., & Mohammadsadeqie, S. (2015). Prophylactic use of intravenous ondansetron versus ketamine - midazolam combination for prevention of shivering during spinal anesthesia: A randomized double-blind placebo-controlled trial. Advanced Biomedical Research, 4, 207. https://doi.org/10.4103/2277-9175.166143
Safavi M, Honarmand A, Mohammadsadeqie S. Prophylactic Use of Intravenous Ondansetron Versus Ketamine - Midazolam Combination for Prevention of Shivering During Spinal Anesthesia: a Randomized Double-blind Placebo-controlled Trial. Adv Biomed Res. 2015;4:207. PubMed PMID: 26605236.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prophylactic use of intravenous ondansetron versus ketamine - midazolam combination for prevention of shivering during spinal anesthesia: A randomized double-blind placebo-controlled trial. AU - Safavi,Mohammadreza, AU - Honarmand,Azim, AU - Mohammadsadeqie,Sara, Y1 - 2015/09/28/ PY - 2013/05/15/received PY - 2015/05/19/accepted PY - 2015/11/26/entrez PY - 2015/11/26/pubmed PY - 2015/11/26/medline KW - Ketamine KW - midazolam KW - ondansetron KW - shivering KW - spinal anesthesia KW - thermoregulation SP - 207 EP - 207 JF - Advanced biomedical research JO - Adv Biomed Res VL - 4 N2 - BACKGROUND: The aim of this study was to compare the efficacy intravenous (IV) ondansetron with ketamine plus midazolam for the prevention of shivering during spinal anesthesia (SA). MATERIALS AND METHODS: Ninety patients, aged 18-65 years, undergoing lower extremity orthopedic surgery were included in the present study. SA was performed in all patients with hyperbaric bupivacaine 15 mg. The patients were randomly allocated to receive normal saline (Group C), ondansetron 8 mg IV (Group O) or ketamine 0.25 mg/kg IV plus midazolam 37.5 μg/kg IV (Group KM) immediately after SA. During surgery, shivering scores were recorded at 5 min intervals. The operating room temperature was maintained at 24°C. RESULTS: The incidences of shivering were 18 (60%) in Group C, 6 (20%) in Group KM and 8 (26.6%) in Group O. The difference between Groups O and Group KM with Group C was statistically significant (P < 0.05). No significant difference was noted between Groups KM with Group O in this regard (P > 0.05). Peripheral and core temperature changes throughout surgery were not significantly different among three groups (P > 0.05). Incidence (%) of hallucination was not significantly different between the three groups (0, 3.3, 0 in Group O, Group KM, Group C respectively, P > 0.05). CONCLUSION: Prophylactic use of ondansetron 8 mg IV was comparable to ketamine 0.25 mg/kg IV plus midazolam 37.5 μg/kg IV in preventing shivering during SA. SN - 2277-9175 UR - https://www.unboundmedicine.com/medline/citation/26605236/Prophylactic_use_of_intravenous_ondansetron_versus_ketamine___midazolam_combination_for_prevention_of_shivering_during_spinal_anesthesia:_A_randomized_double_blind_placebo_controlled_trial_ L2 - http://www.advbiores.net/article.asp?issn=2277-9175;year=2015;volume=4;issue=1;spage=207;epage=207;aulast=Safavi DB - PRIME DP - Unbound Medicine ER -
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