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Ethanolic extract of Trigonella Foenum Graecum attenuates cisplatin-induced nephro- and hepatotoxicities in rats.
Cell Mol Biol (Noisy-le-grand). 2015 Nov 25; 61(7):81-7.CM

Abstract

Nephro-and hepatotoxicities are important complications in cancer patients undergoing cisplatin (CP) therapy. We aimed to study the protective effect of fenugreek (FG) on CP induced renal and hepatic injuries in rats. Cisplatin intoxication resulted in structural and functional renal and hepatic impairments, which were revealed by massive histopathological changes and elevated kidney and liver function tests. However, it was associated with oxidative stress and lipid peroxidation as evident by increased reactive oxygen species (ROS) and malondialdehyde (MDA) with decreased levels of total antioxidant activity. Cisplatin administration triggered inflammatory responses and apoptosis in rat livers and kidneys as evident by increased expression of pro-inflammatory cytokine, tumor necrosis factor- α (TNF-α) and apoptotic marker p38 mitogen-activated protein kinase (p38 MAPK) as results of overproduction of ROS. FG significantly attenuated the cisplatin-induced biochemical and histopathological alterations, inflammation and apoptosis in rat livers and kidneys. Results suggested that fenugreek co-administration has a powerful antioxidant effect and may serves as a novel and promising preventive strategy against cisplatin-induced nephron- and hepatotoxicities.

Authors+Show Affiliations

Ain Shams University Biochemistry Department, Faculty of Science Cairo Egypt marwa_hegazy2000@yahoo.com.Ain Shams University Biochemistry Department, Faculty of Science Cairo Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26612737

Citation

Hegazy, Marwa G A., and Manal A. Emam. "Ethanolic Extract of Trigonella Foenum Graecum Attenuates Cisplatin-induced Nephro- and Hepatotoxicities in Rats." Cellular and Molecular Biology (Noisy-le-Grand, France), vol. 61, no. 7, 2015, pp. 81-7.
Hegazy MG, Emam MA. Ethanolic extract of Trigonella Foenum Graecum attenuates cisplatin-induced nephro- and hepatotoxicities in rats. Cell Mol Biol (Noisy-le-grand). 2015;61(7):81-7.
Hegazy, M. G., & Emam, M. A. (2015). Ethanolic extract of Trigonella Foenum Graecum attenuates cisplatin-induced nephro- and hepatotoxicities in rats. Cellular and Molecular Biology (Noisy-le-Grand, France), 61(7), 81-7.
Hegazy MG, Emam MA. Ethanolic Extract of Trigonella Foenum Graecum Attenuates Cisplatin-induced Nephro- and Hepatotoxicities in Rats. Cell Mol Biol (Noisy-le-grand). 2015 Nov 25;61(7):81-7. PubMed PMID: 26612737.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethanolic extract of Trigonella Foenum Graecum attenuates cisplatin-induced nephro- and hepatotoxicities in rats. AU - Hegazy,Marwa G A, AU - Emam,Manal A, Y1 - 2015/11/25/ PY - 2015/10/19/received PY - 2015/11/19/accepted PY - 2015/11/28/entrez PY - 2015/11/28/pubmed PY - 2016/9/7/medline SP - 81 EP - 7 JF - Cellular and molecular biology (Noisy-le-Grand, France) JO - Cell Mol Biol (Noisy-le-grand) VL - 61 IS - 7 N2 - Nephro-and hepatotoxicities are important complications in cancer patients undergoing cisplatin (CP) therapy. We aimed to study the protective effect of fenugreek (FG) on CP induced renal and hepatic injuries in rats. Cisplatin intoxication resulted in structural and functional renal and hepatic impairments, which were revealed by massive histopathological changes and elevated kidney and liver function tests. However, it was associated with oxidative stress and lipid peroxidation as evident by increased reactive oxygen species (ROS) and malondialdehyde (MDA) with decreased levels of total antioxidant activity. Cisplatin administration triggered inflammatory responses and apoptosis in rat livers and kidneys as evident by increased expression of pro-inflammatory cytokine, tumor necrosis factor- α (TNF-α) and apoptotic marker p38 mitogen-activated protein kinase (p38 MAPK) as results of overproduction of ROS. FG significantly attenuated the cisplatin-induced biochemical and histopathological alterations, inflammation and apoptosis in rat livers and kidneys. Results suggested that fenugreek co-administration has a powerful antioxidant effect and may serves as a novel and promising preventive strategy against cisplatin-induced nephron- and hepatotoxicities. SN - 1165-158X UR - https://www.unboundmedicine.com/medline/citation/26612737/Ethanolic_extract_of_Trigonella_Foenum_Graecum_attenuates_cisplatin_induced_nephro__and_hepatotoxicities_in_rats_ L2 - https://medlineplus.gov/drugreactions.html DB - PRIME DP - Unbound Medicine ER -