TY - JOUR T1 - De novo arteriovenous malformation in a patient with hereditary hemorrhagic telangiectasia. AU - Shimoda,Yusuke, AU - Osanai,Toshiya, AU - Nakayama,Naoki, AU - Ushikoshi,Satoshi, AU - Hokari,Masaaki, AU - Shichinohe,Hideo, AU - Abumiya,Takeo, AU - Kazumata,Ken, AU - Houkin,Kiyohiro, Y1 - 2015/11/27/ PY - 2015/11/28/entrez PY - 2015/11/28/pubmed PY - 2016/7/9/medline KW - AVM = arteriovenous malformation KW - DSA = digital subtraction angiography KW - HHT = hereditary hemorrhagic telangiectasia KW - Rendu-Osler-Weber syndrome KW - VEGF = vascular endothelial growth factor KW - de novo arteriovenous malformation KW - hereditary hemorrhagic telangiectasia KW - vascular disorders SP - 330 EP - 5 JF - Journal of neurosurgery. Pediatrics JO - J Neurosurg Pediatr VL - 17 IS - 3 N2 - Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant systemic disorder characterized by the enlargement of capillaries, recurrent nosebleeds, and multiple arteriovenous malformations (AVMs). Although cerebral AVMs are traditionally considered to be congenital lesions, some reports have described de novo AVMs, which suggests that the authors believed them to be dynamic conditions. In this article, the authors describe the case of a 5-year-old boy with HHT in whom a de novo cerebral AVM was detected after a negative MRI result at 5 months. To the authors' knowledge, this is the first report of a de novo AVM in a patient with HHT. In patients with a family history of HHT, de novo AVMs are possible, even when no lesions are detected at the first screening. Therefore, regular screenings need to be performed, and the family should be informed that AVMs could still develop despite normal MRI results. SN - 1933-0715 UR - https://www.unboundmedicine.com/medline/citation/26613274/De_novo_arteriovenous_malformation_in_a_patient_with_hereditary_hemorrhagic_telangiectasia_ DB - PRIME DP - Unbound Medicine ER -