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Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection: A population-based analysis.

Abstract

BACKGROUND

This study evaluated hospitalization and mortality in patients with chronic hepatitis B virus infection (HBV (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (Vaccine (+)).

METHODS

Data from Taiwan's National Health Insurance program from 2000 to 2009 were used to identify HBV(+)/vaccine(+) (n=4434), HBV(+)/Vaccine(-) (n=3646), HBV(-)/Vaccine(+) (n=8868), and HBV(-)/Vaccine(-) (n=8868) cohorts. The risk of pneumonia/influenza, respiratory failure, intensive care, hospitalization, and mortality in the four cohorts was evaluated.

RESULTS

The total hospitalization rate was significantly lower in patients with chronic HBV infection who received an annual influenza vaccination than in chronic HBV-infected patients who did not receive an influenza vaccination (16.29 vs. 24.02 per 100 person-years), contributing to an adjusted hazard ratio (HR) of 0.56 (95% confidence interval (CI)=0.50-0.62). The HBV(+)/Vaccine(+) cohort also had lower risks than the HBV(+)/Vaccine(-) cohort for pneumonia and influenza (adjusted HR=0.79, 95% CI=0.67-0.92), intensive care unit admission (adjusted HR=0.33, 95% CI=0.25-0.43), and mortality (adjusted HR=0.19, 95% CI=0.15-0.24).

CONCLUSIONS

Our results suggest that annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection.

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  • Authors+Show Affiliations

    ,

    Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; Department of Family Medicine, School of Medicine, Taipei Medical University, Taipei, Taiwan; Master Program in Long-Term Care, College of Nursing, Taipei medical University, Taipei, Taiwan; School of Medicine, Flinders University, Bedford Park, Adelaide, SA, Australia.

    ,

    Department of Public Health, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan.

    ,

    Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.

    ,

    Department of Family Medicine, Taipei Medical University Hospital, Taipei, Taiwan; School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan.

    ,

    Department of Gastroenterology and Hepatology, Yuan's General Hospital, Kaoshiung, Taiwan.

    ,

    Management Office for Health Data, China Medical University Hospital, Taichung, Taiwan; Graduate Institute of Clinical Medical Science, School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.

    School of Public Health, College of Public Health and Nutrition, Taipei Medical University, Taipei, Taiwan; Department of Public Health, China Medical University, Taichung, Taiwan. Electronic address: ccyeh@tmu.edu.tw.

    Source

    Vaccine 34:1 2016 Jan 2 pg 120-7

    MeSH

    Aged
    Child
    Child, Preschool
    Critical Care
    Female
    Hepatitis B, Chronic
    Hospitalization
    Humans
    Infant
    Influenza Vaccines
    Influenza, Human
    Male
    Middle Aged
    Respiratory Insufficiency
    Risk Assessment
    Survival Analysis
    Taiwan
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    ENG

    PubMed ID

    26614589

    Citation

    TY - JOUR T1 - Annual influenza vaccination reduces total hospitalization in patients with chronic hepatitis B virus infection: A population-based analysis. AU - Su,Fu-Hsiung, AU - Huang,Ya-Li, AU - Sung,Fung-Chang, AU - Su,Chien-Tien, AU - Hsu,Wen-Hsin, AU - Chang,Shih-Ni, AU - Yeh,Chih-Ching, Y1 - 2015/Nov/21/ PY - 2015/2/4/received PY - 2015/9/3/revised PY - 2015/10/28/accepted PY - 2015/11/29/entrez PY - 2015/11/29/pubmed PY - 2016/11/15/medline KW - Hepatitis B virus KW - Influenza KW - Population-based study KW - Vaccination SP - 120 EP - 7 JF - Vaccine JO - Vaccine VL - 34 IS - 1 N2 - BACKGROUND: This study evaluated hospitalization and mortality in patients with chronic hepatitis B virus infection (HBV (+)) and matched comparison patients after stratifying the patients according to annual influenza vaccination (Vaccine (+)). METHODS: Data from Taiwan's National Health Insurance program from 2000 to 2009 were used to identify HBV(+)/vaccine(+) (n=4434), HBV(+)/Vaccine(-) (n=3646), HBV(-)/Vaccine(+) (n=8868), and HBV(-)/Vaccine(-) (n=8868) cohorts. The risk of pneumonia/influenza, respiratory failure, intensive care, hospitalization, and mortality in the four cohorts was evaluated. RESULTS: The total hospitalization rate was significantly lower in patients with chronic HBV infection who received an annual influenza vaccination than in chronic HBV-infected patients who did not receive an influenza vaccination (16.29 vs. 24.02 per 100 person-years), contributing to an adjusted hazard ratio (HR) of 0.56 (95% confidence interval (CI)=0.50-0.62). The HBV(+)/Vaccine(+) cohort also had lower risks than the HBV(+)/Vaccine(-) cohort for pneumonia and influenza (adjusted HR=0.79, 95% CI=0.67-0.92), intensive care unit admission (adjusted HR=0.33, 95% CI=0.25-0.43), and mortality (adjusted HR=0.19, 95% CI=0.15-0.24). CONCLUSIONS: Our results suggest that annual influenza vaccination can reduce the risk of hospitalization and mortality in patients with chronic HBV infection. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/26614589/full_citation L2 - http://linkinghub.elsevier.com/retrieve/pii/S0264-410X(15)01585-6 ER -