Tags

Type your tag names separated by a space and hit enter

Association of Coffee Consumption With Overall and Cause-Specific Mortality in a Large US Prospective Cohort Study.
Am J Epidemiol 2015; 182(12):1010-22AJ

Abstract

Concerns about high caffeine intake and coffee as a vehicle for added fat and sugar have raised questions about the net impact of coffee on health. Although inverse associations have been observed for overall mortality, data for cause-specific mortality are sparse. Additionally, few studies have considered exclusively decaffeinated coffee intake or use of coffee additives. Coffee intake was assessed at baseline by self-report in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Hazard ratios were estimated using Cox proportional hazards models. Among 90,317 US adults without cancer at study baseline (1998-2001) or history of cardiovascular disease at study enrollment (1993-2001), 8,718 deaths occurred during 805,644 person-years of follow-up from 1998 through 2009. Following adjustment for smoking and other potential confounders, coffee drinkers, as compared with nondrinkers, had lower hazard ratios for overall mortality (<1 cup/day: hazard ratio (HR) = 0.99 (95% confidence interval (CI): 0.92, 1.07); 1 cup/day: HR = 0.94 (95% CI: 0.87, 1.02); 2-3 cups/day: HR = 0.82 (95% CI: 0.77, 0.88); 4-5 cups/day: HR = 0.79 (95% CI: 0.72, 0.86); ≥6 cups/day: HR = 0.84 (95% CI: 0.75, 0.95)). Similar findings were observed for decaffeinated coffee and coffee additives. Inverse associations were observed for deaths from heart disease, chronic respiratory diseases, diabetes, pneumonia and influenza, and intentional self-harm, but not cancer. Coffee may reduce mortality risk by favorably affecting inflammation, lung function, insulin sensitivity, and depression.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

26614599

Citation

Loftfield, Erikka, et al. "Association of Coffee Consumption With Overall and Cause-Specific Mortality in a Large US Prospective Cohort Study." American Journal of Epidemiology, vol. 182, no. 12, 2015, pp. 1010-22.
Loftfield E, Freedman ND, Graubard BI, et al. Association of Coffee Consumption With Overall and Cause-Specific Mortality in a Large US Prospective Cohort Study. Am J Epidemiol. 2015;182(12):1010-22.
Loftfield, E., Freedman, N. D., Graubard, B. I., Guertin, K. A., Black, A., Huang, W. Y., ... Sinha, R. (2015). Association of Coffee Consumption With Overall and Cause-Specific Mortality in a Large US Prospective Cohort Study. American Journal of Epidemiology, 182(12), pp. 1010-22. doi:10.1093/aje/kwv146.
Loftfield E, et al. Association of Coffee Consumption With Overall and Cause-Specific Mortality in a Large US Prospective Cohort Study. Am J Epidemiol. 2015 Dec 15;182(12):1010-22. PubMed PMID: 26614599.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of Coffee Consumption With Overall and Cause-Specific Mortality in a Large US Prospective Cohort Study. AU - Loftfield,Erikka, AU - Freedman,Neal D, AU - Graubard,Barry I, AU - Guertin,Kristin A, AU - Black,Amanda, AU - Huang,Wen-Yi, AU - Shebl,Fatma M, AU - Mayne,Susan T, AU - Sinha,Rashmi, Y1 - 2015/11/27/ PY - 2015/04/15/received PY - 2015/06/01/accepted PY - 2015/11/29/entrez PY - 2015/11/29/pubmed PY - 2016/4/6/medline KW - additives KW - caffeine KW - cause-specific mortality KW - coffee KW - mortality SP - 1010 EP - 22 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 182 IS - 12 N2 - Concerns about high caffeine intake and coffee as a vehicle for added fat and sugar have raised questions about the net impact of coffee on health. Although inverse associations have been observed for overall mortality, data for cause-specific mortality are sparse. Additionally, few studies have considered exclusively decaffeinated coffee intake or use of coffee additives. Coffee intake was assessed at baseline by self-report in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial. Hazard ratios were estimated using Cox proportional hazards models. Among 90,317 US adults without cancer at study baseline (1998-2001) or history of cardiovascular disease at study enrollment (1993-2001), 8,718 deaths occurred during 805,644 person-years of follow-up from 1998 through 2009. Following adjustment for smoking and other potential confounders, coffee drinkers, as compared with nondrinkers, had lower hazard ratios for overall mortality (<1 cup/day: hazard ratio (HR) = 0.99 (95% confidence interval (CI): 0.92, 1.07); 1 cup/day: HR = 0.94 (95% CI: 0.87, 1.02); 2-3 cups/day: HR = 0.82 (95% CI: 0.77, 0.88); 4-5 cups/day: HR = 0.79 (95% CI: 0.72, 0.86); ≥6 cups/day: HR = 0.84 (95% CI: 0.75, 0.95)). Similar findings were observed for decaffeinated coffee and coffee additives. Inverse associations were observed for deaths from heart disease, chronic respiratory diseases, diabetes, pneumonia and influenza, and intentional self-harm, but not cancer. Coffee may reduce mortality risk by favorably affecting inflammation, lung function, insulin sensitivity, and depression. SN - 1476-6256 UR - https://www.unboundmedicine.com/medline/citation/26614599/Association_of_Coffee_Consumption_With_Overall_and_Cause_Specific_Mortality_in_a_Large_US_Prospective_Cohort_Study_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwv146 DB - PRIME DP - Unbound Medicine ER -