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Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells.
Nutr Neurosci. 2017 May; 20(4):238-245.NN

Abstract

OBJECTIVES

The present study was carried out to determine if lyophilized açaí fruit pulp (genus, Euterpe), rich in polyphenols and other bioactive antioxidant and anti-inflammatory phytochemicals, is efficacious in reversing age-related cognitive deficits in aged rats.

METHODS

The diets of 19-month-old Fischer 344 rats were supplemented for 8 weeks with 2% Euterpe oleracea (EO), Euterpe precatoria (EP), or a control diet. Rats were tested in the Morris water maze and then blood serum from the rats was used to assess inflammatory responses of BV-2 microglial cells.

RESULTS

After 8 weeks of dietary supplementation with 2% EO or EP, rats demonstrated improved working memory in the Morris water maze, relative to controls; however, only the EO diet improved reference memory. BV-2 microglial cells treated with blood serum collected from EO-fed rats produced less nitric oxide (NO) than control-fed rats. Serum from both EO- and EP-fed rats reduced tumor necrosis factor-alpha (TNF-α). There is a relationship between performance in the water maze and the production of NO and TNF-α by serum-treated BV-2 cells, such that serum from rats with better performance was more protective against inflammatory signaling.

DISCUSSION

Protection of memory during aging by supplementation of lyophilized açaí fruit pulp added to the diet may result from its ability to influence antioxidant and anti-inflammatory signaling.

Authors+Show Affiliations

a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA. b Department of Psychology , Simmons College , Boston , MA , USA.a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA.a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA.a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA.b Department of Psychology , Simmons College , Boston , MA , USA.a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA.a Neuroscience and Aging , USDA HNRC on Aging at Tufts University , Boston , MA , USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26618555

Citation

Carey, Amanda N., et al. "Dietary Supplementation With the Polyphenol-rich Açaí Pulps (Euterpe Oleracea Mart. and Euterpe Precatoria Mart.) Improves Cognition in Aged Rats and Attenuates Inflammatory Signaling in BV-2 Microglial Cells." Nutritional Neuroscience, vol. 20, no. 4, 2017, pp. 238-245.
Carey AN, Miller MG, Fisher DR, et al. Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells. Nutr Neurosci. 2017;20(4):238-245.
Carey, A. N., Miller, M. G., Fisher, D. R., Bielinski, D. F., Gilman, C. K., Poulose, S. M., & Shukitt-Hale, B. (2017). Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells. Nutritional Neuroscience, 20(4), 238-245. https://doi.org/10.1080/1028415X.2015.1115213
Carey AN, et al. Dietary Supplementation With the Polyphenol-rich Açaí Pulps (Euterpe Oleracea Mart. and Euterpe Precatoria Mart.) Improves Cognition in Aged Rats and Attenuates Inflammatory Signaling in BV-2 Microglial Cells. Nutr Neurosci. 2017;20(4):238-245. PubMed PMID: 26618555.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary supplementation with the polyphenol-rich açaí pulps (Euterpe oleracea Mart. and Euterpe precatoria Mart.) improves cognition in aged rats and attenuates inflammatory signaling in BV-2 microglial cells. AU - Carey,Amanda N, AU - Miller,Marshall G, AU - Fisher,Derek R, AU - Bielinski,Donna F, AU - Gilman,Casey K, AU - Poulose,Shibu M, AU - Shukitt-Hale,Barbara, Y1 - 2015/11/30/ PY - 2015/12/1/pubmed PY - 2017/9/21/medline PY - 2015/12/1/entrez KW - Aging KW - Açaí KW - Cognition KW - Inflammation KW - Memory KW - Oxidative stress SP - 238 EP - 245 JF - Nutritional neuroscience JO - Nutr Neurosci VL - 20 IS - 4 N2 - OBJECTIVES: The present study was carried out to determine if lyophilized açaí fruit pulp (genus, Euterpe), rich in polyphenols and other bioactive antioxidant and anti-inflammatory phytochemicals, is efficacious in reversing age-related cognitive deficits in aged rats. METHODS: The diets of 19-month-old Fischer 344 rats were supplemented for 8 weeks with 2% Euterpe oleracea (EO), Euterpe precatoria (EP), or a control diet. Rats were tested in the Morris water maze and then blood serum from the rats was used to assess inflammatory responses of BV-2 microglial cells. RESULTS: After 8 weeks of dietary supplementation with 2% EO or EP, rats demonstrated improved working memory in the Morris water maze, relative to controls; however, only the EO diet improved reference memory. BV-2 microglial cells treated with blood serum collected from EO-fed rats produced less nitric oxide (NO) than control-fed rats. Serum from both EO- and EP-fed rats reduced tumor necrosis factor-alpha (TNF-α). There is a relationship between performance in the water maze and the production of NO and TNF-α by serum-treated BV-2 cells, such that serum from rats with better performance was more protective against inflammatory signaling. DISCUSSION: Protection of memory during aging by supplementation of lyophilized açaí fruit pulp added to the diet may result from its ability to influence antioxidant and anti-inflammatory signaling. SN - 1476-8305 UR - https://www.unboundmedicine.com/medline/citation/26618555/Dietary_supplementation_with_the_polyphenol_rich_açaí_pulps__Euterpe_oleracea_Mart__and_Euterpe_precatoria_Mart___improves_cognition_in_aged_rats_and_attenuates_inflammatory_signaling_in_BV_2_microglial_cells_ L2 - https://www.tandfonline.com/doi/full/10.1080/1028415X.2015.1115213 DB - PRIME DP - Unbound Medicine ER -