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Effects of the M1 muscarinic antagonist dicyclomine on emotional memory retrieval.
Behav Neurosci. 2016 Feb; 130(1):29-35.BN

Abstract

Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA.

Authors+Show Affiliations

Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP).Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP).Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP).Department of Psychobiology, Universidade Federal de São Paulo (UNIFESP).

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26619084

Citation

Soares, Juliana Carlota Kramer, et al. "Effects of the M1 Muscarinic Antagonist Dicyclomine On Emotional Memory Retrieval." Behavioral Neuroscience, vol. 130, no. 1, 2016, pp. 29-35.
Soares JC, Perfetto JG, Antonio BB, et al. Effects of the M1 muscarinic antagonist dicyclomine on emotional memory retrieval. Behav Neurosci. 2016;130(1):29-35.
Soares, J. C., Perfetto, J. G., Antonio, B. B., & Oliveira, M. G. (2016). Effects of the M1 muscarinic antagonist dicyclomine on emotional memory retrieval. Behavioral Neuroscience, 130(1), 29-35. https://doi.org/10.1037/bne0000113
Soares JC, et al. Effects of the M1 Muscarinic Antagonist Dicyclomine On Emotional Memory Retrieval. Behav Neurosci. 2016;130(1):29-35. PubMed PMID: 26619084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of the M1 muscarinic antagonist dicyclomine on emotional memory retrieval. AU - Soares,Juliana Carlota Kramer, AU - Perfetto,Juliano Genaro, AU - Antonio,Bruno Brito, AU - Oliveira,Maria Gabriela Menezes, Y1 - 2015/11/30/ PY - 2015/12/1/entrez PY - 2015/12/1/pubmed PY - 2016/10/19/medline SP - 29 EP - 35 JF - Behavioral neuroscience JO - Behav Neurosci VL - 130 IS - 1 N2 - Extensive research has shown the involvement of the central cholinergic system in the acquisition and consolidation of tasks involving conditioned fear responses, such as those observed in contextual fear conditioning (CFC), tone fear conditioning (TFC) and inhibitory avoidance (IA). However, there are few data concerning the role of this system in the memory retrieval process. Therefore, the present study aimed to compare the effects of the administration of an M1 antagonist on retrieval during these tasks. For each behavioral procedure, groups of male Wistar rats were trained. Twenty-four hr later, they were treated with different doses of dicyclomine (16, 32, or 64 mg/kg, i.p.) or with saline 30 min before the test session. The results showed that dicyclomine at doses of 16 and 32 mg/kg impaired CFC without interfering with IA performance. Moreover, only 64 mg/kg impaired TFC. These data suggest that M1 muscarinic receptors contribute to memory retrieval in CFC and TFC but are not essential for retrieval in IA. SN - 1939-0084 UR - https://www.unboundmedicine.com/medline/citation/26619084/Effects_of_the_M1_muscarinic_antagonist_dicyclomine_on_emotional_memory_retrieval_ L2 - http://content.apa.org/journals/bne/130/1/29 DB - PRIME DP - Unbound Medicine ER -