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The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis.
Phytother Res. 2016 Feb; 30(2):283-91.PR

Abstract

Hypoglycemic activity-guided separation of ethanol extracts from the fruits of Cornus officinalis Sieb. et Zucc (CO) led to the isolation of loganin, morroniside, and ursolic acid. The antidiabetic capacity of CO extracts and related compounds was further investigated in diabetes mellitus mice. The results suggested that both CO extracts and pure compounds could ameliorate diabetes-associated damages and complications. Oral administration of loganin and morroniside decreased fasting blood glucose levels in diabetes mellitus mice. Ursolic acid exhibited the highest reactive oxygen species scavenging activity and α-glucosidase inhibitory activity. Notably, we noticed an interesting synergistic effect between loganin and ursolic acid. Given these favorable hypoglycemic properties, C. officinalis, a food and medicinal plant in China, may be used as a valuable food supplement for the treatment of diabetes mellitus.

Authors+Show Affiliations

School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. Department of Clinical Laboratory, Hunan University of Medicine, Hunan, 418000, China. Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. College of Environmental and Biological Engineering, Chongqing Technology and Business University, Chongqing, 400067, China.School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.School of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China. Engineer Research Center of Chongqing Pharmaceutical Process and Quality Control, Chongqing, 400715, China.School of Life Sciences, Southwest University, Chongqing, 400715, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26619955

Citation

He, Kai, et al. "The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated From the Fruits of Cornus Officinalis." Phytotherapy Research : PTR, vol. 30, no. 2, 2016, pp. 283-91.
He K, Song S, Zou Z, et al. The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis. Phytother Res. 2016;30(2):283-91.
He, K., Song, S., Zou, Z., Feng, M., Wang, D., Wang, Y., Li, X., & Ye, X. (2016). The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis. Phytotherapy Research : PTR, 30(2), 283-91. https://doi.org/10.1002/ptr.5529
He K, et al. The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated From the Fruits of Cornus Officinalis. Phytother Res. 2016;30(2):283-91. PubMed PMID: 26619955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Hypoglycemic and Synergistic Effect of Loganin, Morroniside, and Ursolic Acid Isolated from the Fruits of Cornus officinalis. AU - He,Kai, AU - Song,Shanghua, AU - Zou,Zongyao, AU - Feng,Min, AU - Wang,Dezhen, AU - Wang,Yanzhi, AU - Li,Xuegang, AU - Ye,Xiaoli, Y1 - 2015/12/01/ PY - 2015/04/24/received PY - 2015/10/17/revised PY - 2015/11/06/accepted PY - 2015/12/2/entrez PY - 2015/12/2/pubmed PY - 2016/7/2/medline KW - Cornus officinalis KW - hypoglycemic KW - loganin KW - morroniside KW - ursolic acid SP - 283 EP - 91 JF - Phytotherapy research : PTR JO - Phytother Res VL - 30 IS - 2 N2 - Hypoglycemic activity-guided separation of ethanol extracts from the fruits of Cornus officinalis Sieb. et Zucc (CO) led to the isolation of loganin, morroniside, and ursolic acid. The antidiabetic capacity of CO extracts and related compounds was further investigated in diabetes mellitus mice. The results suggested that both CO extracts and pure compounds could ameliorate diabetes-associated damages and complications. Oral administration of loganin and morroniside decreased fasting blood glucose levels in diabetes mellitus mice. Ursolic acid exhibited the highest reactive oxygen species scavenging activity and α-glucosidase inhibitory activity. Notably, we noticed an interesting synergistic effect between loganin and ursolic acid. Given these favorable hypoglycemic properties, C. officinalis, a food and medicinal plant in China, may be used as a valuable food supplement for the treatment of diabetes mellitus. SN - 1099-1573 UR - https://www.unboundmedicine.com/medline/citation/26619955/The_Hypoglycemic_and_Synergistic_Effect_of_Loganin_Morroniside_and_Ursolic_Acid_Isolated_from_the_Fruits_of_Cornus_officinalis_ L2 - https://doi.org/10.1002/ptr.5529 DB - PRIME DP - Unbound Medicine ER -