Tags

Type your tag names separated by a space and hit enter

Effect of restricted protein diet supplemented with keto analogues in chronic kidney disease: a systematic review and meta-analysis.
Int Urol Nephrol. 2016 Mar; 48(3):409-18.IU

Abstract

BACKGROUND

To evaluate the efficacy and safety of the restricted protein diet (low or very low protein diet) supplemented with keto analogues in the treatment of chronic kidney disease (CKD).

METHODS

The Cochrane library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to April 2015. Clinical trials were analyzed using RevMan 5.3 software.

RESULTS

Seven random control trials, one cross-over trial and one non-randomized concurrent control trial were selected and included in this study according to our inclusion and exclusion criteria. The changes of eGFR, BUN, Scr, albumin, PTH, triglyceride, cholesterol, calcium, phosphorus and nutrition indexes (BMI, lean body mass and mid-arm muscular circumference) before and after treatment were analyzed. The meta-analysis results indicated that, comparing with normal protein diet, low protein diet (LPD) or very low protein diet (vLPD) supplemented with keto analogues (s(v)LPD) could significantly prevent the deterioration of eGFR (P < 0.001), hyperparathyroidism (P = 0.04), hypertension (P < 0.01) and hyperphosphatemia (P < 0.001). No differences in BUN, Scr, Albumin, triglyceride, cholesterol, hemoglobin, calcium and nutrition indexes were observed between different protein intake groups.

CONCLUSION

Restricted protein diet supplemented with keto analogues (s(v)LPD) could delay the progression of CKD effectively without causing malnutrition.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Jiang Z
West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Zhang X
West China School of Medicine, Sichuan University, Chengdu, Sichuan, China.
Yang L
Division of Nephrology, Department of Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Li Z
Division of Nephrology, Department of Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Qin W
Division of Nephrology, Department of Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China. ddqstrike@163.com.

MeSH

Diet, Protein-RestrictedDietary SupplementsDisease ProgressionHumansKetosesRenal Insufficiency, Chronic

Pub Type(s)

Journal Article
Meta-Analysis
Review
Systematic Review

Language

eng

PubMed ID

26620578

Citation

Jiang, Zheng, et al. "Effect of Restricted Protein Diet Supplemented With Keto Analogues in Chronic Kidney Disease: a Systematic Review and Meta-analysis." International Urology and Nephrology, vol. 48, no. 3, 2016, pp. 409-18.
Jiang Z, Zhang X, Yang L, et al. Effect of restricted protein diet supplemented with keto analogues in chronic kidney disease: a systematic review and meta-analysis. Int Urol Nephrol. 2016;48(3):409-18.
Jiang, Z., Zhang, X., Yang, L., Li, Z., & Qin, W. (2016). Effect of restricted protein diet supplemented with keto analogues in chronic kidney disease: a systematic review and meta-analysis. International Urology and Nephrology, 48(3), 409-18. https://doi.org/10.1007/s11255-015-1170-2
Jiang Z, et al. Effect of Restricted Protein Diet Supplemented With Keto Analogues in Chronic Kidney Disease: a Systematic Review and Meta-analysis. Int Urol Nephrol. 2016;48(3):409-18. PubMed PMID: 26620578.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of restricted protein diet supplemented with keto analogues in chronic kidney disease: a systematic review and meta-analysis. AU - Jiang,Zheng, AU - Zhang,Xiaoyan, AU - Yang,Lichuan, AU - Li,Zi, AU - Qin,Wei, Y1 - 2015/11/30/ PY - 2015/08/22/received PY - 2015/11/17/accepted PY - 2015/12/2/entrez PY - 2015/12/2/pubmed PY - 2016/12/21/medline KW - Chronic kidney disease KW - Keto analogues KW - Meta-analysis KW - Restricted protein diet KW - Systematic review SP - 409 EP - 18 JF - International urology and nephrology JO - Int Urol Nephrol VL - 48 IS - 3 N2 - BACKGROUND: To evaluate the efficacy and safety of the restricted protein diet (low or very low protein diet) supplemented with keto analogues in the treatment of chronic kidney disease (CKD). METHODS: The Cochrane library, PubMed, Embase, CBM and CENTRAL databases were searched and reviewed up to April 2015. Clinical trials were analyzed using RevMan 5.3 software. RESULTS: Seven random control trials, one cross-over trial and one non-randomized concurrent control trial were selected and included in this study according to our inclusion and exclusion criteria. The changes of eGFR, BUN, Scr, albumin, PTH, triglyceride, cholesterol, calcium, phosphorus and nutrition indexes (BMI, lean body mass and mid-arm muscular circumference) before and after treatment were analyzed. The meta-analysis results indicated that, comparing with normal protein diet, low protein diet (LPD) or very low protein diet (vLPD) supplemented with keto analogues (s(v)LPD) could significantly prevent the deterioration of eGFR (P < 0.001), hyperparathyroidism (P = 0.04), hypertension (P < 0.01) and hyperphosphatemia (P < 0.001). No differences in BUN, Scr, Albumin, triglyceride, cholesterol, hemoglobin, calcium and nutrition indexes were observed between different protein intake groups. CONCLUSION: Restricted protein diet supplemented with keto analogues (s(v)LPD) could delay the progression of CKD effectively without causing malnutrition. SN - 1573-2584 UR - https://www.unboundmedicine.com/medline/citation/26620578/Effect_of_restricted_protein_diet_supplemented_with_keto_analogues_in_chronic_kidney_disease:_a_systematic_review_and_meta_analysis_ DB - PRIME DP - Unbound Medicine ER -