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Heme oxygenase levels and metaflammation in benign prostatic hyperplasia patients.
World J Urol. 2016 Aug; 34(8):1183-92.WJ

Abstract

PURPOSE

To investigate the relationship between intra-prostatic levels of heme oxygenase (HO), metaflammation in benign prostatic hyperplasia (BPH) tissue in patients with MetS and moderate-severe lower urinary tract symptoms (LUTS).

METHODS

Between January 2012 and June 2013, 132 consecutive patients, who underwent transurethral resection of the prostate for moderate-severe LUTS, secondary to clinical BPH, were enrolled. Prostate samples were investigated for the presence of an inflammatory infiltrate, according to the Irani score, and for HO-1 and HO-2 levels measurements. Patients were evaluated for the presence of metabolic syndrome (MetS) defined by the International Diabetes Federation.

RESULTS

We observed that subjects with MetS exhibited greater Irani score (3.0 vs. 2.0; p < 0.05), Irani grade (2.0 vs. 1.0; p < 0.05) and lower value of HO-1 (4.55 vs. 6.01; p < 0.05) and HO-2 (0.81 vs. 2.66; p < 0.05). HO-1 (3.91 vs. 5.67; p < 0.05) and HO-2 (1.06 vs. 1.37; p < 0.05) were significantly reduced in patients with high intra-prostatic inflammation (Irani score ≥4). At the multivariate logistic regression analysis, HO-1 reduction (OR 0.588; p < 0.01), waist circumference (OR 1.09; p < 0.01), triglycerides (OR 1.013; p < 0.05) and HDL (OR 0.750; p < 0.05) were independent predictors of high intra-prostatic inflammation. We also found that HO-1 reduction (OR 0.598; p < 0.01) and the presence of MetS (OR 34.846; p < 0.01) were associated with Irani score ≥4.

CONCLUSION

MetS-induced inflammation may play a key role in BPH. In detail, prostate metaflammation is inversely related to intra-prostatic HO-1 levels, serum HDL and positively with triglycerides.

Authors+Show Affiliations

Department of Urology, School of Medicine, Policlinico Hospital, University of Catania, Catania, Italy. giorgioivan@virgilio.it.Department of Drug Science, Biochemistry Section, University of Catania, Catania, Italy.Department of Urology, School of Medicine, Policlinico Hospital, University of Catania, Catania, Italy.Department of Urology, School of Medicine, Policlinico Hospital, University of Catania, Catania, Italy.Department of Urology, School of Medicine, Policlinico Hospital, University of Catania, Catania, Italy.Department of Urology, School of Medicine, Policlinico Hospital, University of Catania, Catania, Italy.Department of Drug Science, Biochemistry Section, University of Catania, Catania, Italy.Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.Department of Urology, Careggi Hospital, University of Florence, Florence, Italy.Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy.Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy.Department G.F. Ingrassia, Section of Anatomic Pathology, University of Catania, Catania, Italy.Department of Drug Science, Biochemistry Section, University of Catania, Catania, Italy.Department of Urology, School of Medicine, Policlinico Hospital, University of Catania, Catania, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26621207

Citation

Russo, Giorgio Ivan, et al. "Heme Oxygenase Levels and Metaflammation in Benign Prostatic Hyperplasia Patients." World Journal of Urology, vol. 34, no. 8, 2016, pp. 1183-92.
Russo GI, Vanella L, Castelli T, et al. Heme oxygenase levels and metaflammation in benign prostatic hyperplasia patients. World J Urol. 2016;34(8):1183-92.
Russo, G. I., Vanella, L., Castelli, T., Cimino, S., Reale, G., Urzì, D., Li Volti, G., Gacci, M., Carini, M., Motta, F., Caltabiano, R., Puzzo, L., Sorrenti, V., & Morgia, G. (2016). Heme oxygenase levels and metaflammation in benign prostatic hyperplasia patients. World Journal of Urology, 34(8), 1183-92. https://doi.org/10.1007/s00345-015-1736-8
Russo GI, et al. Heme Oxygenase Levels and Metaflammation in Benign Prostatic Hyperplasia Patients. World J Urol. 2016;34(8):1183-92. PubMed PMID: 26621207.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Heme oxygenase levels and metaflammation in benign prostatic hyperplasia patients. AU - Russo,Giorgio Ivan, AU - Vanella,Luca, AU - Castelli,Tommaso, AU - Cimino,Sebastiano, AU - Reale,Giulio, AU - Urzì,Daniele, AU - Li Volti,Giovanni, AU - Gacci,Mauro, AU - Carini,Marco, AU - Motta,Fabio, AU - Caltabiano,Rosario, AU - Puzzo,Lidia, AU - Sorrenti,Valeria, AU - Morgia,Giuseppe, Y1 - 2015/11/30/ PY - 2015/06/20/received PY - 2015/11/18/accepted PY - 2015/12/2/entrez PY - 2015/12/2/pubmed PY - 2017/4/14/medline KW - Benign prostatic hyperplasia KW - Flogosis KW - HDL KW - Heme oxygenase KW - LUTS KW - Metabolic syndrome KW - Prostate KW - Triglycerides SP - 1183 EP - 92 JF - World journal of urology JO - World J Urol VL - 34 IS - 8 N2 - PURPOSE: To investigate the relationship between intra-prostatic levels of heme oxygenase (HO), metaflammation in benign prostatic hyperplasia (BPH) tissue in patients with MetS and moderate-severe lower urinary tract symptoms (LUTS). METHODS: Between January 2012 and June 2013, 132 consecutive patients, who underwent transurethral resection of the prostate for moderate-severe LUTS, secondary to clinical BPH, were enrolled. Prostate samples were investigated for the presence of an inflammatory infiltrate, according to the Irani score, and for HO-1 and HO-2 levels measurements. Patients were evaluated for the presence of metabolic syndrome (MetS) defined by the International Diabetes Federation. RESULTS: We observed that subjects with MetS exhibited greater Irani score (3.0 vs. 2.0; p < 0.05), Irani grade (2.0 vs. 1.0; p < 0.05) and lower value of HO-1 (4.55 vs. 6.01; p < 0.05) and HO-2 (0.81 vs. 2.66; p < 0.05). HO-1 (3.91 vs. 5.67; p < 0.05) and HO-2 (1.06 vs. 1.37; p < 0.05) were significantly reduced in patients with high intra-prostatic inflammation (Irani score ≥4). At the multivariate logistic regression analysis, HO-1 reduction (OR 0.588; p < 0.01), waist circumference (OR 1.09; p < 0.01), triglycerides (OR 1.013; p < 0.05) and HDL (OR 0.750; p < 0.05) were independent predictors of high intra-prostatic inflammation. We also found that HO-1 reduction (OR 0.598; p < 0.01) and the presence of MetS (OR 34.846; p < 0.01) were associated with Irani score ≥4. CONCLUSION: MetS-induced inflammation may play a key role in BPH. In detail, prostate metaflammation is inversely related to intra-prostatic HO-1 levels, serum HDL and positively with triglycerides. SN - 1433-8726 UR - https://www.unboundmedicine.com/medline/citation/26621207/Heme_oxygenase_levels_and_metaflammation_in_benign_prostatic_hyperplasia_patients_ L2 - https://dx.doi.org/10.1007/s00345-015-1736-8 DB - PRIME DP - Unbound Medicine ER -