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Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases.

Abstract

The oxidative-antioxidative status is closely associated with the progression of systemic lupus erythematosus (SLE), and oxidative stress is customarily found in patients with SLE. N-acetylcysteine (NAC), a typical antioxidant, is reliable and often applied for clinical treatment. Lupus nephritis (LN) is a kidney disorder associated with SLE, but the treatment of LN with antioxidants is rarely documented. The present report describes two cases of early-stage LN that were orally treated with 1,200 mg NAC in addition to the standard therapy with hydroxychloroquine and calcitriol. Following the NAC administration, the glutathione level largely increased while the level of the lipid peroxidation biomarker 8-iso-prostaglandin F2α declined in both cases. In addition, the routine blood counts, 24-h urine protein, erythrocyte sedimentation rate and the SLE disease activity index were markedly improved. In conclusion, the present report of two cases has shown that NAC, as an antioxidant, may exert a beneficial effect to modulate the oxidative status in LN; however, the underlying mechanisms require further investigation.

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  • Authors+Show Affiliations

    ,

    Department of Rheumatism and Immunity, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China ; Department of Rheumatism and Immunity, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

    ,

    Department of Ultrasound, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

    ,

    Department of Rheumatism and Immunity, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

    ,

    Department of Rheumatism and Immunity, Weifang People's Hospital, Weifang, Shandong 261041, P.R. China.

    Department of Rheumatism and Immunity, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China.

    Source

    Experimental and therapeutic medicine 10:2 2015 Aug pg 689-692

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    26622376

    Citation

    Li, Ming, et al. "Early-stage Lupus Nephritis Treated With N-acetylcysteine: a Report of Two Cases." Experimental and Therapeutic Medicine, vol. 10, no. 2, 2015, pp. 689-692.
    Li M, Gao W, Ma J, et al. Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases. Exp Ther Med. 2015;10(2):689-692.
    Li, M., Gao, W., Ma, J., Zhu, Y., & Li, X. (2015). Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases. Experimental and Therapeutic Medicine, 10(2), pp. 689-692.
    Li M, et al. Early-stage Lupus Nephritis Treated With N-acetylcysteine: a Report of Two Cases. Exp Ther Med. 2015;10(2):689-692. PubMed PMID: 26622376.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Early-stage lupus nephritis treated with N-acetylcysteine: A report of two cases. AU - Li,Ming, AU - Gao,Wenjuan, AU - Ma,Jingjing, AU - Zhu,Yun, AU - Li,Xingfu, Y1 - 2015/05/21/ PY - 2015/01/14/received PY - 2015/04/21/accepted PY - 2015/12/2/entrez PY - 2015/12/2/pubmed PY - 2015/12/2/medline KW - N-acetylcysteine KW - case report KW - lupus nephritis KW - oxidative stress SP - 689 EP - 692 JF - Experimental and therapeutic medicine JO - Exp Ther Med VL - 10 IS - 2 N2 - The oxidative-antioxidative status is closely associated with the progression of systemic lupus erythematosus (SLE), and oxidative stress is customarily found in patients with SLE. N-acetylcysteine (NAC), a typical antioxidant, is reliable and often applied for clinical treatment. Lupus nephritis (LN) is a kidney disorder associated with SLE, but the treatment of LN with antioxidants is rarely documented. The present report describes two cases of early-stage LN that were orally treated with 1,200 mg NAC in addition to the standard therapy with hydroxychloroquine and calcitriol. Following the NAC administration, the glutathione level largely increased while the level of the lipid peroxidation biomarker 8-iso-prostaglandin F2α declined in both cases. In addition, the routine blood counts, 24-h urine protein, erythrocyte sedimentation rate and the SLE disease activity index were markedly improved. In conclusion, the present report of two cases has shown that NAC, as an antioxidant, may exert a beneficial effect to modulate the oxidative status in LN; however, the underlying mechanisms require further investigation. SN - 1792-0981 UR - https://www.unboundmedicine.com/medline/citation/26622376/full_citation L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1792-0981&volume=10&issue=2&spage=689&aulast=Li DB - PRIME DP - Unbound Medicine ER -