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[An improvement in insulin efficacy in patients with type-1 diabetes mellitus following treatment using an insulin infusion pump].
Vutr Boles. 1989; 28(1):74-7.VB

Abstract

In 8 patients with diabetes mellitus type I two methods for intensified insulin treatment were compared: method of numerous insulin applications and treatment with a subcutaneous insulin pump (Microjet model of "Miles" company). The following were taken into consideration: daily insulin dose, residuary beta-cell secretion (determined by a venous Tolbutamide test and dynamic follow up of C-peptide), peripherial insulin efficiency (M) determined in vivo by an euglycemic hyperinsulinemic clamp-technique (Biostator). The infusion pump treatment imitates the beta-cell function better than the numerous insulin applications. This method of treatment helps in overcoming the insulin deficiency and the jatrogenic hyperinsulinemia and as a result the metabolic compensation and insulin efficiency are improved.

Authors

Borisova AM
No affiliation info available
Koev D
No affiliation info available
Kirilov G
No affiliation info available

MeSH

Blood GlucoseC-PeptideChronic DiseaseDiabetes Mellitus, Type 1Drug EvaluationHumansInsulinInsulin Infusion SystemsTolbutamide

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

bul

PubMed ID

2662610

Citation

Borisova, A M., et al. "[An Improvement in Insulin Efficacy in Patients With Type-1 Diabetes Mellitus Following Treatment Using an Insulin Infusion Pump]." Vutreshni Bolesti, vol. 28, no. 1, 1989, pp. 74-7.
Borisova AM, Koev D, Kirilov G. [An improvement in insulin efficacy in patients with type-1 diabetes mellitus following treatment using an insulin infusion pump]. Vutr Boles. 1989;28(1):74-7.
Borisova, A. M., Koev, D., & Kirilov, G. (1989). [An improvement in insulin efficacy in patients with type-1 diabetes mellitus following treatment using an insulin infusion pump]. Vutreshni Bolesti, 28(1), 74-7.
Borisova AM, Koev D, Kirilov G. [An Improvement in Insulin Efficacy in Patients With Type-1 Diabetes Mellitus Following Treatment Using an Insulin Infusion Pump]. Vutr Boles. 1989;28(1):74-7. PubMed PMID: 2662610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [An improvement in insulin efficacy in patients with type-1 diabetes mellitus following treatment using an insulin infusion pump]. AU - Borisova,A M, AU - Koev,D, AU - Kirilov,G, PY - 1989/1/1/pubmed PY - 1989/1/1/medline PY - 1989/1/1/entrez SP - 74 EP - 7 JF - Vutreshni bolesti JO - Vutr Boles VL - 28 IS - 1 N2 - In 8 patients with diabetes mellitus type I two methods for intensified insulin treatment were compared: method of numerous insulin applications and treatment with a subcutaneous insulin pump (Microjet model of "Miles" company). The following were taken into consideration: daily insulin dose, residuary beta-cell secretion (determined by a venous Tolbutamide test and dynamic follow up of C-peptide), peripherial insulin efficiency (M) determined in vivo by an euglycemic hyperinsulinemic clamp-technique (Biostator). The infusion pump treatment imitates the beta-cell function better than the numerous insulin applications. This method of treatment helps in overcoming the insulin deficiency and the jatrogenic hyperinsulinemia and as a result the metabolic compensation and insulin efficiency are improved. SN - 0506-2772 UR - https://www.unboundmedicine.com/medline/citation/2662610/[An_improvement_in_insulin_efficacy_in_patients_with_type_1_diabetes_mellitus_following_treatment_using_an_insulin_infusion_pump]_ DB - PRIME DP - Unbound Medicine ER -