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Association between whole grain intake and stroke risk: evidence from a meta-analysis.
Int J Clin Exp Med 2015; 8(9):16978-83IJ

Abstract

BACKGROUND

Researches of the relationships between dietary whole grains intake and risk of stroke have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence from observed studies regarding the association between whole grain intake and stroke risk.

METHODS

Pertinent studies were identified by searching Web of Knowledge and PubMed up to May 2015. Random-effect model was used to combine the relative risk (RR) with the corresponding 95% confidence intervals (CI). Publication bias was estimated using Egger's regression asymmetry test.

RESULTS

Six prospective studies involving 1635 stroke cases and 247487 participants were included in this meta-analysis. Pooled results suggested that highest category of whole grain intake versus lowest category was significantly associated with reduced the risk of stroke [summary RR = 0.86, 95% CI = 0.73-0.99, I2 = 0.0%]. Inverse associations were also found in the America population [summary RR = 0.81, 95% CI = 0.67-0.98, I(2) = 0.0%] and subgroup analysis of females [summary RR = 0.78, 95% CI = 0.63-0.97, I(2) = 0.0%]. No publication bias was found.

CONCLUSION

Our analysis indicated that higher whole grain intake has a protective effect on stroke.

Authors+Show Affiliations

Department of Neurology, Fourth Affiliated Hospital, Haerbin, Medical University Haerbin 150001, China.Department of Neurosurgery, The First Affiliated Hospital of Soochow University Suzhou 215006, China.Department of Neurology, Fourth Affiliated Hospital, Haerbin, Medical University Haerbin 150001, China.Department of Neurology, Fourth Affiliated Hospital, Haerbin, Medical University Haerbin 150001, China.Department of Neurology, Fourth Affiliated Hospital, Haerbin, Medical University Haerbin 150001, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26629253

Citation

Fang, Liqun, et al. "Association Between Whole Grain Intake and Stroke Risk: Evidence From a Meta-analysis." International Journal of Clinical and Experimental Medicine, vol. 8, no. 9, 2015, pp. 16978-83.
Fang L, Li W, Zhang W, et al. Association between whole grain intake and stroke risk: evidence from a meta-analysis. Int J Clin Exp Med. 2015;8(9):16978-83.
Fang, L., Li, W., Zhang, W., Wang, Y., & Fu, S. (2015). Association between whole grain intake and stroke risk: evidence from a meta-analysis. International Journal of Clinical and Experimental Medicine, 8(9), pp. 16978-83.
Fang L, et al. Association Between Whole Grain Intake and Stroke Risk: Evidence From a Meta-analysis. Int J Clin Exp Med. 2015;8(9):16978-83. PubMed PMID: 26629253.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between whole grain intake and stroke risk: evidence from a meta-analysis. AU - Fang,Liqun, AU - Li,Wen, AU - Zhang,Wenjie, AU - Wang,Yanan, AU - Fu,Songbin, Y1 - 2015/09/15/ PY - 2015/07/08/received PY - 2015/09/07/accepted PY - 2015/12/3/entrez PY - 2015/12/3/pubmed PY - 2015/12/3/medline KW - Whole grain KW - meta-analysis KW - stroke SP - 16978 EP - 83 JF - International journal of clinical and experimental medicine JO - Int J Clin Exp Med VL - 8 IS - 9 N2 - BACKGROUND: Researches of the relationships between dietary whole grains intake and risk of stroke have produced inconsistent results. We therefore conducted a meta-analysis to summarize the evidence from observed studies regarding the association between whole grain intake and stroke risk. METHODS: Pertinent studies were identified by searching Web of Knowledge and PubMed up to May 2015. Random-effect model was used to combine the relative risk (RR) with the corresponding 95% confidence intervals (CI). Publication bias was estimated using Egger's regression asymmetry test. RESULTS: Six prospective studies involving 1635 stroke cases and 247487 participants were included in this meta-analysis. Pooled results suggested that highest category of whole grain intake versus lowest category was significantly associated with reduced the risk of stroke [summary RR = 0.86, 95% CI = 0.73-0.99, I2 = 0.0%]. Inverse associations were also found in the America population [summary RR = 0.81, 95% CI = 0.67-0.98, I(2) = 0.0%] and subgroup analysis of females [summary RR = 0.78, 95% CI = 0.63-0.97, I(2) = 0.0%]. No publication bias was found. CONCLUSION: Our analysis indicated that higher whole grain intake has a protective effect on stroke. SN - 1940-5901 UR - https://www.unboundmedicine.com/medline/citation/26629253/Association_between_whole_grain_intake_and_stroke_risk:_evidence_from_a_meta_analysis_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26629253/ DB - PRIME DP - Unbound Medicine ER -