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Alphacoronaviruses Detected in French Bats Are Phylogeographically Linked to Coronaviruses of European Bats.
Viruses. 2015 Dec 02; 7(12):6279-90.V

Abstract

Bats are a reservoir for a diverse range of viruses, including coronaviruses (CoVs). To determine the presence of CoVs in French bats, fecal samples were collected between July and August of 2014 from four bat species in seven different locations around the city of Bourges in France. We present for the first time the presence of alpha-CoVs in French Pipistrellus pipistrellus bat species with an estimated prevalence of 4.2%. Based on the analysis of a fragment of the RNA-dependent RNA polymerase (RdRp) gene, phylogenetic analyses show that alpha-CoVs sequences detected in French bats are closely related to other European bat alpha-CoVs. Phylogeographic analyses of RdRp sequences show that several CoVs strains circulate in European bats: (i) old strains detected that have probably diverged a long time ago and are detected in different bat subspecies; (ii) strains detected in Myotis and Pipistrellus bat species that have more recently diverged. Our findings support previous observations describing the complexity of the detected CoVs in bats worldwide.

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Authors+Show Affiliations

Goffard A
Molecular & Cellular Virology, University Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Centre d'Infection et d'Immunité de Lille, Bâtiment IBL. 1 rue du Pr. Calmette CS 50447, 59021 Lille Cedex, France. anne.goffard@univ-lille2.fr.
Demanche C
Bacterial Respiratory Infections: Pertussis and Tuberculosis, University Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Centre d'Infection et d'Immunité de Lille, F-59000 Lille, France. christine.demanche@univ-lille2.fr.
Arthur L
Museum d'Histoire Naturelle de Bourges, Les Rives d'Auron, allée René Ménard, 18000 Bourges, France. laurent.arthur@ville-bourges.fr.
Pinçon C
University Lille, CHU Lille, EA 2694-Santé publique: épidémiologie et qualité des soins, F-59000 Lille, France. claire.pincon@univ-lille2.fr.
Michaux J
Conservation Genetics Unit, Institute of Botany (B. 22), University Liège, 4000 Liège, Belgium. johan.michaux@ulg.ac.be. CIRAD TA C-22/E-Campus international de Baillarguet, 34398 Montpellier Cedex 5, France. johan.michaux@ulg.ac.be.
Dubuisson J
Molecular & Cellular Virology, University Lille, CNRS, Inserm, CHU Lille, Institut Pasteur de Lille, U1019-UMR 8204-CIIL-Centre d'Infection et d'Immunité de Lille, Bâtiment IBL. 1 rue du Pr. Calmette CS 50447, 59021 Lille Cedex, France. jean.dubuisson@ibl.cnrs.fr.

MeSH

AnimalsChiropteraCluster AnalysisCoronavirusCoronavirus InfectionsFecesFrancePhylogeographyPrevalenceRNA, ViralRNA-Dependent RNA PolymeraseSequence Analysis, DNASequence Homology

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26633467

Citation

Goffard, Anne, et al. "Alphacoronaviruses Detected in French Bats Are Phylogeographically Linked to Coronaviruses of European Bats." Viruses, vol. 7, no. 12, 2015, pp. 6279-90.
Goffard A, Demanche C, Arthur L, et al. Alphacoronaviruses Detected in French Bats Are Phylogeographically Linked to Coronaviruses of European Bats. Viruses. 2015;7(12):6279-90.
Goffard, A., Demanche, C., Arthur, L., Pinçon, C., Michaux, J., & Dubuisson, J. (2015). Alphacoronaviruses Detected in French Bats Are Phylogeographically Linked to Coronaviruses of European Bats. Viruses, 7(12), 6279-90. https://doi.org/10.3390/v7122937
Goffard A, et al. Alphacoronaviruses Detected in French Bats Are Phylogeographically Linked to Coronaviruses of European Bats. Viruses. 2015 Dec 2;7(12):6279-90. PubMed PMID: 26633467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alphacoronaviruses Detected in French Bats Are Phylogeographically Linked to Coronaviruses of European Bats. AU - Goffard,Anne, AU - Demanche,Christine, AU - Arthur,Laurent, AU - Pinçon,Claire, AU - Michaux,Johan, AU - Dubuisson,Jean, Y1 - 2015/12/02/ PY - 2015/09/14/received PY - 2015/11/17/revised PY - 2015/11/23/accepted PY - 2015/12/4/entrez PY - 2015/12/4/pubmed PY - 2016/9/30/medline KW - Europe KW - alphacoronavirus KW - bats KW - coronavirus KW - molecular characterization KW - phylogenetic analysis KW - phylogeographic analysis SP - 6279 EP - 90 JF - Viruses JO - Viruses VL - 7 IS - 12 N2 - Bats are a reservoir for a diverse range of viruses, including coronaviruses (CoVs). To determine the presence of CoVs in French bats, fecal samples were collected between July and August of 2014 from four bat species in seven different locations around the city of Bourges in France. We present for the first time the presence of alpha-CoVs in French Pipistrellus pipistrellus bat species with an estimated prevalence of 4.2%. Based on the analysis of a fragment of the RNA-dependent RNA polymerase (RdRp) gene, phylogenetic analyses show that alpha-CoVs sequences detected in French bats are closely related to other European bat alpha-CoVs. Phylogeographic analyses of RdRp sequences show that several CoVs strains circulate in European bats: (i) old strains detected that have probably diverged a long time ago and are detected in different bat subspecies; (ii) strains detected in Myotis and Pipistrellus bat species that have more recently diverged. Our findings support previous observations describing the complexity of the detected CoVs in bats worldwide. SN - 1999-4915 UR - https://www.unboundmedicine.com/medline/citation/26633467/Alphacoronaviruses_Detected_in_French_Bats_Are_Phylogeographically_Linked_to_Coronaviruses_of_European_Bats_ DB - PRIME DP - Unbound Medicine ER -