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Body mass index and risk of subtypes of head-neck cancer: the Netherlands Cohort Study.
Sci Rep 2015; 5:17744SR

Abstract

Low body mass index (BMI) has been associated with risk of head-neck cancer (HNC), but prospective data are scarce. We investigated the association between BMI, BMI at age 20 years and change in BMI during adulthood with risk of HNC and HNC subtypes. 120,852 participants completed a questionnaire on diet and other cancer risk factors, including anthropometric measurements, at baseline in 1986. After 20.3 years of follow-up, 411 HNC (127 oral cavity cancer (OCC), 84 oro-/hypopharyngeal cancer (OHPC), and 197 laryngeal cancer (LC)) cases and 3,980 subcohort members were available for case-cohort analysis using Cox proportional hazards models. BMI at baseline was inversely associated with risk of HNC overall, with a multivariate rate ratio of 3.31 (95% CI 1.40-7.82) for subjects with a BMI < 18.5 kg/m(2), compared to participants with a BMI of 18.5 to 25 kg/m(2). Among HNC subtypes, this association was strongest for OCC and OHPC. The association between BMI at age 20 and HNC risk appeared to be positive. In this large prospective cohort study, we found an inverse association between BMI at baseline and HNC risk. For BMI at age 20, however, a positive rather than inverse association was found.

Authors+Show Affiliations

Department of Epidemiology, GROW - School for Oncology &Developmental Biology, Maastricht University, Maastricht, The Netherlands.Department of Epidemiology, GROW - School for Oncology &Developmental Biology, Maastricht University, Maastricht, The Netherlands.Department of Otorhinolaryngology, Head &Neck Surgery, GROW - School for Oncology &Developmental Biology, Maastricht University Medical Center, Maastricht, The Netherlands.Department of Epidemiology, GROW - School for Oncology &Developmental Biology, Maastricht University, Maastricht, The Netherlands.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26634678

Citation

Maasland, Denise H E., et al. "Body Mass Index and Risk of Subtypes of Head-neck Cancer: the Netherlands Cohort Study." Scientific Reports, vol. 5, 2015, p. 17744.
Maasland DH, van den Brandt PA, Kremer B, et al. Body mass index and risk of subtypes of head-neck cancer: the Netherlands Cohort Study. Sci Rep. 2015;5:17744.
Maasland, D. H., van den Brandt, P. A., Kremer, B., & Schouten, L. J. (2015). Body mass index and risk of subtypes of head-neck cancer: the Netherlands Cohort Study. Scientific Reports, 5, p. 17744. doi:10.1038/srep17744.
Maasland DH, et al. Body Mass Index and Risk of Subtypes of Head-neck Cancer: the Netherlands Cohort Study. Sci Rep. 2015 Dec 4;5:17744. PubMed PMID: 26634678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Body mass index and risk of subtypes of head-neck cancer: the Netherlands Cohort Study. AU - Maasland,Denise H E, AU - van den Brandt,Piet A, AU - Kremer,Bernd, AU - Schouten,Leo J, Y1 - 2015/12/04/ PY - 2015/05/29/received PY - 2015/11/05/accepted PY - 2015/12/5/entrez PY - 2015/12/5/pubmed PY - 2016/10/8/medline SP - 17744 EP - 17744 JF - Scientific reports JO - Sci Rep VL - 5 N2 - Low body mass index (BMI) has been associated with risk of head-neck cancer (HNC), but prospective data are scarce. We investigated the association between BMI, BMI at age 20 years and change in BMI during adulthood with risk of HNC and HNC subtypes. 120,852 participants completed a questionnaire on diet and other cancer risk factors, including anthropometric measurements, at baseline in 1986. After 20.3 years of follow-up, 411 HNC (127 oral cavity cancer (OCC), 84 oro-/hypopharyngeal cancer (OHPC), and 197 laryngeal cancer (LC)) cases and 3,980 subcohort members were available for case-cohort analysis using Cox proportional hazards models. BMI at baseline was inversely associated with risk of HNC overall, with a multivariate rate ratio of 3.31 (95% CI 1.40-7.82) for subjects with a BMI < 18.5 kg/m(2), compared to participants with a BMI of 18.5 to 25 kg/m(2). Among HNC subtypes, this association was strongest for OCC and OHPC. The association between BMI at age 20 and HNC risk appeared to be positive. In this large prospective cohort study, we found an inverse association between BMI at baseline and HNC risk. For BMI at age 20, however, a positive rather than inverse association was found. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/26634678/Body_mass_index_and_risk_of_subtypes_of_head_neck_cancer:_the_Netherlands_Cohort_Study_ L2 - http://dx.doi.org/10.1038/srep17744 DB - PRIME DP - Unbound Medicine ER -