TY - JOUR T1 - Use of labetalol and methyldopa in pregnancy-induced hypertension. AU - Lamming,G D, AU - Symonds,E B, PY - 2015/12/5/entrez PY - 1979/4/1/pubmed PY - 1979/4/1/medline SP - 217S EP - 22S JF - British journal of clinical pharmacology JO - Br J Clin Pharmacol VL - 8 Suppl 2 N2 - 1 Nineteen pregnant patients whose mean arterial pressure (MAP) was persistently greater than or equal to 103.3 mmHg were given labetalol or methyldopa. 2 Singificant falls (P less than 0.001) in BP only occurred in the group treated with labetalol, and daily BP control was better in this group. 3 Two severely hypertensive patients were successfully treated with intravenous labetalol. 4 There was a higher incidence of spontaneous labour in the labetalol group and a significant difference (P less than 0.05) in the Bishop score of the cervix between the two groups. 5 There were no apparent detrimental effects on the foetus antenatally, during labour or post partum. 6 Slight breathlessness in one patient treated with labetalol was the only side-effect observed but drowsiness, headache and postural hypotension were reported in patients receiving methyldopa. SN - 0306-5251 UR - https://www.unboundmedicine.com/medline/citation/26635170/Use_of_labetalol_and_methyldopa_in_pregnancy_induced_hypertension_ DB - PRIME DP - Unbound Medicine ER -