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Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults.
J Musculoskelet Neuronal Interact. 2015 Dec; 15(4):350-7.JM

Abstract

OBJECTIVES

To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults.

METHODS

48 community-dwelling older adults aged ⋝65 years (mean 71.6±4.8 years; 52% women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66% tibia), to assess calf IMAT cross-sectional area ([CSA]; cm2) and muscle density (mg/cm(3); higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40).

RESULTS

Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95%CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P<0.03), while higher muscle density was associated with smaller step width (P<0.01) only.

CONCLUSIONS

Older adults with higher calf IMAT have poorer balance, mobility and inflammatory status. Interventions aimed at improving physical function in older adults should incorporate strategies to reduce IMAT.

Authors+Show Affiliations

Department of Medicine, School of Clinical Sciences at Monash Health, Faculty of Medicine, Nursing and Health Sciences, Monash University, Clayton, Australia.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26636281

Citation

Scott, D, et al. "Associations of Calf Inter- and Intra-muscular Adipose Tissue With Cardiometabolic Health and Physical Function in Community-dwelling Older Adults." Journal of Musculoskeletal & Neuronal Interactions, vol. 15, no. 4, 2015, pp. 350-7.
Scott D, Trbojevic T, Skinner E, et al. Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults. J Musculoskelet Neuronal Interact. 2015;15(4):350-7.
Scott, D., Trbojevic, T., Skinner, E., Clark, R. A., Levinger, P., Haines, T. P., Sanders, K. M., & Ebeling, P. R. (2015). Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults. Journal of Musculoskeletal & Neuronal Interactions, 15(4), 350-7.
Scott D, et al. Associations of Calf Inter- and Intra-muscular Adipose Tissue With Cardiometabolic Health and Physical Function in Community-dwelling Older Adults. J Musculoskelet Neuronal Interact. 2015;15(4):350-7. PubMed PMID: 26636281.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of calf inter- and intra-muscular adipose tissue with cardiometabolic health and physical function in community-dwelling older adults. AU - Scott,D, AU - Trbojevic,T, AU - Skinner,E, AU - Clark,R A, AU - Levinger,P, AU - Haines,T P, AU - Sanders,K M, AU - Ebeling,P R, PY - 2015/12/5/entrez PY - 2015/12/5/pubmed PY - 2016/9/15/medline SP - 350 EP - 7 JF - Journal of musculoskeletal & neuronal interactions JO - J Musculoskelet Neuronal Interact VL - 15 IS - 4 N2 - OBJECTIVES: To determine associations of inter- and intra-muscular adipose tissue (IMAT) with cardiometabolic health and physical function in older adults. METHODS: 48 community-dwelling older adults aged ⋝65 years (mean 71.6±4.8 years; 52% women) underwent whole-body dual-energy X-ray absorptiometry, to assess appendicular lean mass (ALM), and peripheral quantitative computed tomography (pQCT; 66% tibia), to assess calf IMAT cross-sectional area ([CSA]; cm2) and muscle density (mg/cm(3); higher values indicate lower fat infiltration). Fasting glucose, lipids, triglycerides and C-reactive protein (CRP) were analysed. Physical function was assessed by postural sway (computerised posturography; N=41), and gait analysis (GAITRite Electronic Walkway; N=40). RESULTS: Higher IMAT CSA and muscle density were associated with significantly higher (B=0.85 95%CI [0.34, 1.36]) and lower (-2.14 [-4.20, -0.08]) CRP and higher (0.93 [0.56, 1.30]) and lower postural sway (-3.12 [-4.74, -1.50]), respectively, after adjustment for age, sex and ALM/BMI. Higher IMAT CSA was associated with slower gait speed and cadence, and greater step time and step width (all P<0.03), while higher muscle density was associated with smaller step width (P<0.01) only. CONCLUSIONS: Older adults with higher calf IMAT have poorer balance, mobility and inflammatory status. Interventions aimed at improving physical function in older adults should incorporate strategies to reduce IMAT. SN - 1108-7161 UR - https://www.unboundmedicine.com/medline/citation/26636281/Associations_of_calf_inter__and_intra_muscular_adipose_tissue_with_cardiometabolic_health_and_physical_function_in_community_dwelling_older_adults_ L2 - http://www.ismni.org/jmni/pdf/62/V15I4_07SCOTT.pdf DB - PRIME DP - Unbound Medicine ER -