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Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate.
Pak J Pharm Sci. 2015 Nov; 28(6):2019-25.PJ

Abstract

The purpose of this study was to introduce the technology for the development of rate-controlled oral drug delivery system to overcome various physiological problems. Several approaches are being used for the purpose of increasing the gastric retentive time, including floating drug delivery system. Gastric floating lisinopril maleate and metoprolol tartrate bilayer tablets were formulated by direct compression method using the sodium starch glycolate, crosscarmellose sodium for IR layer. Eudragit L100, pectin, acacia as sustained release polymers in different ratios for SR metoprolol tartrate layer and sodium bicarbonate, citric acid as gas generating agents for the floating extended release layer. The floating bilayer tablets of lisinopril maleate and metoprolol tartrate were designed to overcome the various problems associated with conventional oral dosage form. Floating tablets were evaluated for floating lag time, drug contents and in-vitro dissolution profile and different kinetic release models were applied. It was clear that the different ratios of polymers affected the drug release and floating time. L2 and M4 showed good drug release profile and floating behavior. The linear regression and model fitting showed that all formulation followed Higuchi model of drug release model except M4 that followed zero order kinetic. From the study it is evident that a promising controlled release by floating bilyer tablets of lisinopril maleate and metoprolol tartrate can be developed successfully.

Authors+Show Affiliations

Ijaz H
College of Pharmacy, Govt. College University Faisalabad, Pakistan.
Qureshi J
College of Pharmacy, Govt. College University Faisalabad, Pakistan.
Danish Z
University College of Pharmacy, University of the Punjab, Lahore, Pakistan.
Zaman M
Faculty of Pharmacy, The University of Lahore, Pakistan.
Abdel-Daim M
Pharmacology Department, Faculty of Veterinary Medicine,Suez Canal University, Ismailia, Egypt.
Hanif M
Department of Pharmacy, BZU Multan, Pakistan.
Waheed I
Akhtar Saeed college of Pharmaceutical Sciences, Lahore, Pakistan.
Mohammad IS
Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China.

MeSH

Administration, OralAdrenergic beta-1 Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsChemistry, PharmaceuticalDelayed-Action PreparationsDrug StabilityExcipientsKineticsLisinoprilMetoprololModels, ChemicalSolubilityTabletsTechnology, Pharmaceutical

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26639495

Citation

Ijaz, Hira, et al. "Formulation and In-vitro Evaluation of Floating Bilayer Tablet of Lisinopril Maleate and Metoprolol Tartrate." Pakistan Journal of Pharmaceutical Sciences, vol. 28, no. 6, 2015, pp. 2019-25.
Ijaz H, Qureshi J, Danish Z, et al. Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate. Pak J Pharm Sci. 2015;28(6):2019-25.
Ijaz, H., Qureshi, J., Danish, Z., Zaman, M., Abdel-Daim, M., Hanif, M., Waheed, I., & Mohammad, I. S. (2015). Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate. Pakistan Journal of Pharmaceutical Sciences, 28(6), 2019-25.
Ijaz H, et al. Formulation and In-vitro Evaluation of Floating Bilayer Tablet of Lisinopril Maleate and Metoprolol Tartrate. Pak J Pharm Sci. 2015;28(6):2019-25. PubMed PMID: 26639495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and in-vitro evaluation of floating bilayer tablet of lisinopril maleate and metoprolol tartrate. AU - Ijaz,Hira, AU - Qureshi,Junaid, AU - Danish,Zeeshan, AU - Zaman,Muhammad, AU - Abdel-Daim,Mohamed, AU - Hanif,Muhammad, AU - Waheed,Imran, AU - Mohammad,Imran Shair, PY - 2015/12/8/entrez PY - 2015/12/8/pubmed PY - 2016/3/11/medline SP - 2019 EP - 25 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 28 IS - 6 N2 - The purpose of this study was to introduce the technology for the development of rate-controlled oral drug delivery system to overcome various physiological problems. Several approaches are being used for the purpose of increasing the gastric retentive time, including floating drug delivery system. Gastric floating lisinopril maleate and metoprolol tartrate bilayer tablets were formulated by direct compression method using the sodium starch glycolate, crosscarmellose sodium for IR layer. Eudragit L100, pectin, acacia as sustained release polymers in different ratios for SR metoprolol tartrate layer and sodium bicarbonate, citric acid as gas generating agents for the floating extended release layer. The floating bilayer tablets of lisinopril maleate and metoprolol tartrate were designed to overcome the various problems associated with conventional oral dosage form. Floating tablets were evaluated for floating lag time, drug contents and in-vitro dissolution profile and different kinetic release models were applied. It was clear that the different ratios of polymers affected the drug release and floating time. L2 and M4 showed good drug release profile and floating behavior. The linear regression and model fitting showed that all formulation followed Higuchi model of drug release model except M4 that followed zero order kinetic. From the study it is evident that a promising controlled release by floating bilyer tablets of lisinopril maleate and metoprolol tartrate can be developed successfully. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/26639495/Formulation_and_in_vitro_evaluation_of_floating_bilayer_tablet_of_lisinopril_maleate_and_metoprolol_tartrate_ DB - PRIME DP - Unbound Medicine ER -