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Formulation and evaluation of gastroretentive controlled release tablets of alfuzosin hydrochloride.
Pak J Pharm Sci. 2015 Nov; 28(6):2147-52.PJ

Abstract

Alfuzosin hydrochloride is a novel drug used in the treatment of urinary incontinency. The purpose of this research was to develop controlled release floating matrix formulations of Alfuzosin HCl. Floating matrix tablets of Alfuzosin HCl were prepared using hydroxypropyl methylcellulose (HPMC), Polyethylene oxide (PEO), Carbopol 971P NF polymer (Direct compressible) and Blend of Polyvinyl Acetate and Povidone 30 (80:19:1(0.8% sodium laury sulfate and 0.2% silica)). Combination of citric acid and sodium bicarbonate were also used as gas forming agent. Matrix formulations were prepared by direct compression method and evaluated for floating, in vitro drug release profile and swelling characteristics. The mechanism of drug release was found to follow non-Fickian or anomalous type. The data obtained from the invitro release studies demonstrated that the floating matrix tablets containing HPMC 100K CR (controlled-release) and carbopol along with sodium CMC were found to sustain the release of drug over a period of 12 hours. Formulations containing 25% PEO 303WSR was also capable of sustaining delivery the release of Alfuzosin HCl.

Authors+Show Affiliations

Pulla Reddy Institute of Pharmacy near Dundigal Airforce Academy, Annaram, Hyderabad Andhra Pradesh, India.Pulla Reddy Institute of Pharmacy near Dundigal Airforce Academy, Annaram, Hyderabad Andhra Pradesh, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26639508

Citation

Rudraswamy-Math, Nijaguni Revansiddayya, and Vankdari Rama-Mohan Gupta. "Formulation and Evaluation of Gastroretentive Controlled Release Tablets of Alfuzosin Hydrochloride." Pakistan Journal of Pharmaceutical Sciences, vol. 28, no. 6, 2015, pp. 2147-52.
Rudraswamy-Math NR, Gupta VR. Formulation and evaluation of gastroretentive controlled release tablets of alfuzosin hydrochloride. Pak J Pharm Sci. 2015;28(6):2147-52.
Rudraswamy-Math, N. R., & Gupta, V. R. (2015). Formulation and evaluation of gastroretentive controlled release tablets of alfuzosin hydrochloride. Pakistan Journal of Pharmaceutical Sciences, 28(6), 2147-52.
Rudraswamy-Math NR, Gupta VR. Formulation and Evaluation of Gastroretentive Controlled Release Tablets of Alfuzosin Hydrochloride. Pak J Pharm Sci. 2015;28(6):2147-52. PubMed PMID: 26639508.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formulation and evaluation of gastroretentive controlled release tablets of alfuzosin hydrochloride. AU - Rudraswamy-Math,Nijaguni Revansiddayya, AU - Gupta,Vankdari Rama-Mohan, PY - 2015/12/8/entrez PY - 2015/12/8/pubmed PY - 2016/3/11/medline SP - 2147 EP - 52 JF - Pakistan journal of pharmaceutical sciences JO - Pak J Pharm Sci VL - 28 IS - 6 N2 - Alfuzosin hydrochloride is a novel drug used in the treatment of urinary incontinency. The purpose of this research was to develop controlled release floating matrix formulations of Alfuzosin HCl. Floating matrix tablets of Alfuzosin HCl were prepared using hydroxypropyl methylcellulose (HPMC), Polyethylene oxide (PEO), Carbopol 971P NF polymer (Direct compressible) and Blend of Polyvinyl Acetate and Povidone 30 (80:19:1(0.8% sodium laury sulfate and 0.2% silica)). Combination of citric acid and sodium bicarbonate were also used as gas forming agent. Matrix formulations were prepared by direct compression method and evaluated for floating, in vitro drug release profile and swelling characteristics. The mechanism of drug release was found to follow non-Fickian or anomalous type. The data obtained from the invitro release studies demonstrated that the floating matrix tablets containing HPMC 100K CR (controlled-release) and carbopol along with sodium CMC were found to sustain the release of drug over a period of 12 hours. Formulations containing 25% PEO 303WSR was also capable of sustaining delivery the release of Alfuzosin HCl. SN - 1011-601X UR - https://www.unboundmedicine.com/medline/citation/26639508/Formulation_and_evaluation_of_gastroretentive_controlled_release_tablets_of_alfuzosin_hydrochloride_ DB - PRIME DP - Unbound Medicine ER -