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An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice.
J Alzheimers Dis. 2016; 50(1):189-200.JA

Abstract

The progressive aggregation of amyloid-β protein (Aβ) into senile plaques is a major pathological factor of Alzheimer's disease (AD) and is believed to result in memory impairment. We aimed to investigate the effect of an optimized combination of ginger and peony root (OCGP), a standardized herbal mixture of ginger and peony root, on Aβ accumulation and memory impairment in amyloid-β protein precursor (AβPP)/presenilin 1 (PS1) double-transgenic mice. In an in vitro thioflavin T fluorescence assay, 100 μg/ml OCGP inhibited Aβ accumulation to the same extent as did 10 μM curcumin. Furthermore, AβPP/PS1 double-transgenic mice treated with OCGP (50 or 100 mg/kg/day given orally for 14 weeks) exhibited reduced Aβ plaque accumulation in the hippocampus and lower levels of glial fibrillary acid protein and cyclooxygease-2 expression compared with vehicle-treated controls. These results suggest that OCGP may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain.

Authors+Show Affiliations

Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.Department of Biochemistry, College of Medicine, Konyang University, Daejeon, Republic of Korea.Department of Oriental Pharmaceutical Science, College of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.CJ Healthcare R&D center, Majang-myeon, Icheon, Gyeonggi, Republic of Korea.CJ Healthcare R&D center, Majang-myeon, Icheon, Gyeonggi, Republic of Korea.CJ Healthcare R&D center, Majang-myeon, Icheon, Gyeonggi, Republic of Korea.Gachon Institute of Pharmaceutical Science, Gachon University, Yeonsu-gu, Incheon, Republic of Korea.Department of Life and Nanopharmaceutical Science, Graduate School, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea. Department of Oriental Pharmaceutical Science, College of Pharmacy and Kyung Hee East-West Pharmaceutical Research Institute, Kyung Hee University, Dongdaemun-gu, Seoul, Republic of Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26639976

Citation

Lim, Soonmin, et al. "An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice." Journal of Alzheimer's Disease : JAD, vol. 50, no. 1, 2016, pp. 189-200.
Lim S, Choi JG, Moon M, et al. An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice. J Alzheimers Dis. 2016;50(1):189-200.
Lim, S., Choi, J. G., Moon, M., Kim, H. G., Lee, W., Bak, H. R., Sung, H., Park, C. H., Kim, S. Y., & Oh, M. S. (2016). An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice. Journal of Alzheimer's Disease : JAD, 50(1), 189-200. https://doi.org/10.3233/JAD-150839
Lim S, et al. An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice. J Alzheimers Dis. 2016;50(1):189-200. PubMed PMID: 26639976.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An Optimized Combination of Ginger and Peony Root Effectively Inhibits Amyloid-β Accumulation and Amyloid-β-Mediated Pathology in AβPP/PS1 Double-Transgenic Mice. AU - Lim,Soonmin, AU - Choi,Jin Gyu, AU - Moon,Minho, AU - Kim,Hyo Geun, AU - Lee,Wonil, AU - Bak,Hyoung-Rok, AU - Sung,Hachang, AU - Park,Chi Hye, AU - Kim,Sun Yeou, AU - Oh,Myung Sook, PY - 2015/12/8/entrez PY - 2015/12/8/pubmed PY - 2016/10/8/medline KW - Aβ accumulation KW - AβPP/PS1 double-transgenic mice KW - neuroinflammation KW - optimized combination of ginger and peony root SP - 189 EP - 200 JF - Journal of Alzheimer's disease : JAD JO - J Alzheimers Dis VL - 50 IS - 1 N2 - The progressive aggregation of amyloid-β protein (Aβ) into senile plaques is a major pathological factor of Alzheimer's disease (AD) and is believed to result in memory impairment. We aimed to investigate the effect of an optimized combination of ginger and peony root (OCGP), a standardized herbal mixture of ginger and peony root, on Aβ accumulation and memory impairment in amyloid-β protein precursor (AβPP)/presenilin 1 (PS1) double-transgenic mice. In an in vitro thioflavin T fluorescence assay, 100 μg/ml OCGP inhibited Aβ accumulation to the same extent as did 10 μM curcumin. Furthermore, AβPP/PS1 double-transgenic mice treated with OCGP (50 or 100 mg/kg/day given orally for 14 weeks) exhibited reduced Aβ plaque accumulation in the hippocampus and lower levels of glial fibrillary acid protein and cyclooxygease-2 expression compared with vehicle-treated controls. These results suggest that OCGP may prevent memory impairment in AD by inhibiting Aβ accumulation and inflammation in the brain. SN - 1875-8908 UR - https://www.unboundmedicine.com/medline/citation/26639976/An_Optimized_Combination_of_Ginger_and_Peony_Root_Effectively_Inhibits_Amyloid_β_Accumulation_and_Amyloid_β_Mediated_Pathology_in_AβPP/PS1_Double_Transgenic_Mice_ DB - PRIME DP - Unbound Medicine ER -