Tags

Type your tag names separated by a space and hit enter

Gastric cancer risk in relation to tobacco use and alcohol drinking in Kerala, India--Karunagappally cohort study.

Abstract

AIM

To assess the risk of gastric cancer (GC) in relation to tobacco use and alcohol drinking in the Karunagappally cohort in Kerala, South India.

METHODS

This study examined the association of tobacco use and alcohol drinking with GC incidence among 65553 men aged 30-84 in the Karunagappally cohort. During the period from 1990-2009, 116 GC cases in the cohort were identified as incident cancers. These cases were identified from the population-based cancer registry. Information regarding risk factors such as socioeconomic factors and tobacco and alcohol habits of cohort members were collected from the database of the baseline survey conducted during 1990-1997. The relative risks (RRs) and the corresponding 95% confidence intervals (95%CIs) for tobacco use were obtained from Poisson regression analysis of grouped survival data, considering age, follow-up period, occupation and education.

RESULTS

Bidi smoking was associated with GC risk (P = 0.042). The RR comparing current versus never smokers was 1.6 (95%CI: 1.0-2.5). GC risk was associated with the number of bidis smoked daily (P = 0.012) and with the duration of bidi smoking (P = 0.036). Those who started bidi smoking at younger ages were at an elevated GC risk; the RRs for those starting bidi smoking under the age of 18 and ages 18-22 were 2.0 (95%CI: 1.0-3.9) and 1.8 (95%CI: 1.1-2.9), respectively, when their risks were compared with lifetime non-smokers of bidis. Bidi smoking increased the risk of GC among never cigarette smokers more evidently (RR = 2.2; 95%CI: 1.3-4.0). GC risk increased with the cumulative amount of bidi smoking, which was calculated as the number of bidis smoked per day x years of smoking (bidi-year; P = 0.017). Cigarette smoking, tobacco chewing or alcohol drinking was not significantly associated with GC risk.

CONCLUSION

Among a male cohort in South India, gastric cancer risk increased with the number and duration of bidi smoking.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • FREE Publisher Full Text
  • Authors+Show Affiliations

    ,

    Padmavathy Amma Jayalekshmi, Natural Background Radiation Cancer Registry, Karunagappally, Kerala 690536, India.

    ,

    Padmavathy Amma Jayalekshmi, Natural Background Radiation Cancer Registry, Karunagappally, Kerala 690536, India.

    ,

    Padmavathy Amma Jayalekshmi, Natural Background Radiation Cancer Registry, Karunagappally, Kerala 690536, India.

    ,

    Padmavathy Amma Jayalekshmi, Natural Background Radiation Cancer Registry, Karunagappally, Kerala 690536, India.

    ,

    Padmavathy Amma Jayalekshmi, Natural Background Radiation Cancer Registry, Karunagappally, Kerala 690536, India.

    Padmavathy Amma Jayalekshmi, Natural Background Radiation Cancer Registry, Karunagappally, Kerala 690536, India.

    Source

    World journal of gastroenterology 21:44 2015 Nov 28 pg 12676-85

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Health Surveys
    Humans
    Incidence
    India
    Male
    Middle Aged
    Odds Ratio
    Prospective Studies
    Registries
    Risk Assessment
    Risk Factors
    Smoking
    Stomach Neoplasms
    Time Factors
    Tobacco Products

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    26640345

    Citation

    Jayalekshmi, Padmavathy Amma, et al. "Gastric Cancer Risk in Relation to Tobacco Use and Alcohol Drinking in Kerala, India--Karunagappally Cohort Study." World Journal of Gastroenterology, vol. 21, no. 44, 2015, pp. 12676-85.
    Jayalekshmi PA, Hassani S, Nandakumar A, et al. Gastric cancer risk in relation to tobacco use and alcohol drinking in Kerala, India--Karunagappally cohort study. World J Gastroenterol. 2015;21(44):12676-85.
    Jayalekshmi, P. A., Hassani, S., Nandakumar, A., Koriyama, C., Sebastian, P., & Akiba, S. (2015). Gastric cancer risk in relation to tobacco use and alcohol drinking in Kerala, India--Karunagappally cohort study. World Journal of Gastroenterology, 21(44), pp. 12676-85. doi:10.3748/wjg.v21.i44.12676.
    Jayalekshmi PA, et al. Gastric Cancer Risk in Relation to Tobacco Use and Alcohol Drinking in Kerala, India--Karunagappally Cohort Study. World J Gastroenterol. 2015 Nov 28;21(44):12676-85. PubMed PMID: 26640345.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Gastric cancer risk in relation to tobacco use and alcohol drinking in Kerala, India--Karunagappally cohort study. AU - Jayalekshmi,Padmavathy Amma, AU - Hassani,Soroush, AU - Nandakumar,Athira, AU - Koriyama,Chihaya, AU - Sebastian,Paul, AU - Akiba,Suminori, PY - 2015/04/20/received PY - 2015/07/13/revised PY - 2015/09/02/accepted PY - 2015/12/8/entrez PY - 2015/12/8/pubmed PY - 2016/11/8/medline KW - Alcohol drinking KW - Bidi smoking KW - Gastric cancer KW - India KW - Kerala KW - The Karunagappally cohort SP - 12676 EP - 85 JF - World journal of gastroenterology JO - World J. Gastroenterol. VL - 21 IS - 44 N2 - AIM: To assess the risk of gastric cancer (GC) in relation to tobacco use and alcohol drinking in the Karunagappally cohort in Kerala, South India. METHODS: This study examined the association of tobacco use and alcohol drinking with GC incidence among 65553 men aged 30-84 in the Karunagappally cohort. During the period from 1990-2009, 116 GC cases in the cohort were identified as incident cancers. These cases were identified from the population-based cancer registry. Information regarding risk factors such as socioeconomic factors and tobacco and alcohol habits of cohort members were collected from the database of the baseline survey conducted during 1990-1997. The relative risks (RRs) and the corresponding 95% confidence intervals (95%CIs) for tobacco use were obtained from Poisson regression analysis of grouped survival data, considering age, follow-up period, occupation and education. RESULTS: Bidi smoking was associated with GC risk (P = 0.042). The RR comparing current versus never smokers was 1.6 (95%CI: 1.0-2.5). GC risk was associated with the number of bidis smoked daily (P = 0.012) and with the duration of bidi smoking (P = 0.036). Those who started bidi smoking at younger ages were at an elevated GC risk; the RRs for those starting bidi smoking under the age of 18 and ages 18-22 were 2.0 (95%CI: 1.0-3.9) and 1.8 (95%CI: 1.1-2.9), respectively, when their risks were compared with lifetime non-smokers of bidis. Bidi smoking increased the risk of GC among never cigarette smokers more evidently (RR = 2.2; 95%CI: 1.3-4.0). GC risk increased with the cumulative amount of bidi smoking, which was calculated as the number of bidis smoked per day x years of smoking (bidi-year; P = 0.017). Cigarette smoking, tobacco chewing or alcohol drinking was not significantly associated with GC risk. CONCLUSION: Among a male cohort in South India, gastric cancer risk increased with the number and duration of bidi smoking. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/26640345/Gastric_cancer_risk_in_relation_to_tobacco_use_and_alcohol_drinking_in_Kerala_India__Karunagappally_cohort_study_ L2 - http://www.wjgnet.com/1007-9327/full/v21/i44/12676.htm DB - PRIME DP - Unbound Medicine ER -