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Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System.
Oxid Med Cell Longev. 2016; 2016:6904327.OM

Abstract

Historically acknowledged as toxic gases, hydrogen sulfide (H2S) and nitric oxide (NO) are now recognized as the predominant members of a new family of signaling molecules, "gasotransmitters" in mammals. While H2S is biosynthesized by three constitutively expressed enzymes (CBS, CSE, and 3-MST) from L-cysteine and homocysteine, NO is generated endogenously from L-arginine by the action of various isoforms of NOS. Both gases have been transpired as the key and independent regulators of many physiological functions in mammalian cardiovascular, nervous, gastrointestinal, respiratory, and immune systems. The analogy between these two gasotransmitters is evident not only from their paracrine mode of signaling, but also from the identical and/or shared signaling transduction pathways. With the plethora of research in the pathophysiological role of gasotransmitters in various systems, the existence of interplay between these gases is being widely accepted. Chemical interaction between NO and H2S may generate nitroxyl (HNO), which plays a specific effective role within the cardiovascular system. In this review article, we have attempted to provide current understanding of the individual and interactive roles of H2S and NO signaling in mammalian cardiovascular system, focusing particularly on heart contractility, cardioprotection, vascular tone, angiogenesis, and oxidative stress.

Authors+Show Affiliations

Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26640616

Citation

Nagpure, B V., and Jin-Song Bian. "Interaction of Hydrogen Sulfide With Nitric Oxide in the Cardiovascular System." Oxidative Medicine and Cellular Longevity, vol. 2016, 2016, p. 6904327.
Nagpure BV, Bian JS. Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System. Oxid Med Cell Longev. 2016;2016:6904327.
Nagpure, B. V., & Bian, J. S. (2016). Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System. Oxidative Medicine and Cellular Longevity, 2016, 6904327. https://doi.org/10.1155/2016/6904327
Nagpure BV, Bian JS. Interaction of Hydrogen Sulfide With Nitric Oxide in the Cardiovascular System. Oxid Med Cell Longev. 2016;2016:6904327. PubMed PMID: 26640616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction of Hydrogen Sulfide with Nitric Oxide in the Cardiovascular System. AU - Nagpure,B V, AU - Bian,Jin-Song, Y1 - 2015/11/10/ PY - 2015/04/05/received PY - 2015/06/21/accepted PY - 2015/12/8/entrez PY - 2015/12/8/pubmed PY - 2016/9/9/medline SP - 6904327 EP - 6904327 JF - Oxidative medicine and cellular longevity JO - Oxid Med Cell Longev VL - 2016 N2 - Historically acknowledged as toxic gases, hydrogen sulfide (H2S) and nitric oxide (NO) are now recognized as the predominant members of a new family of signaling molecules, "gasotransmitters" in mammals. While H2S is biosynthesized by three constitutively expressed enzymes (CBS, CSE, and 3-MST) from L-cysteine and homocysteine, NO is generated endogenously from L-arginine by the action of various isoforms of NOS. Both gases have been transpired as the key and independent regulators of many physiological functions in mammalian cardiovascular, nervous, gastrointestinal, respiratory, and immune systems. The analogy between these two gasotransmitters is evident not only from their paracrine mode of signaling, but also from the identical and/or shared signaling transduction pathways. With the plethora of research in the pathophysiological role of gasotransmitters in various systems, the existence of interplay between these gases is being widely accepted. Chemical interaction between NO and H2S may generate nitroxyl (HNO), which plays a specific effective role within the cardiovascular system. In this review article, we have attempted to provide current understanding of the individual and interactive roles of H2S and NO signaling in mammalian cardiovascular system, focusing particularly on heart contractility, cardioprotection, vascular tone, angiogenesis, and oxidative stress. SN - 1942-0994 UR - https://www.unboundmedicine.com/medline/citation/26640616/Interaction_of_Hydrogen_Sulfide_with_Nitric_Oxide_in_the_Cardiovascular_System_ L2 - https://doi.org/10.1155/2016/6904327 DB - PRIME DP - Unbound Medicine ER -