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The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China.
PLoS One. 2015; 10(12):e0144104.Plos

Abstract

BACKGROUND

Dyslipidemia is a major health problem in China and an important modifiable cardiovascular disease (CVD) risk factor. This study aimed to describe the prevalence of dyslipidemia and low high density lipoprotein cholesterol (HDL-cholesterol) and associated risk factors among adults in rural northwest China.

METHODS

In a cross-sectional analyses involving 2,980 adults aged >18 years, information on the demographics, cigarette smoking, alcohol consumption, education, and medical history was collected via face-to-face interviews. Blood samples were collected to determine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-cholesterol), and HDL-cholesterol, and triglycerides (TG) levels.

RESULTS

The prevalence of high TC, high LDL-cholesterol, low HDL-cholesterol, and high TG were 1.0%, 0.6%, 60.9%, and 13.7%, respectively. TC, LDL-cholesterol, and TG increased with age in females. Elevated TC was more common in females than in males. The prevalence of low HDL-cholesterol was 67.6% in males and 55.4% in females. Current smokers, those with less education, those who were overweight or obese, and those with large waist circumference were more likely to have low HDL-cholesterol (p<0.05). Multivariable regression showed that male gender showed an association with low HDL-cholesterol (OR 2.10, 95%CI 1.68-2.61), age ≥60 years (OR 0.80, 95% CI 0.64-0.99), BMI (BMI = 24-27.9, OR 1.27, 95%CI 1.04-1.54, p = 0.02 and BMI≥28, OR 1.56, 95%CI 1.10-2.20, p = 0.01) and enlarged waist circumference (OR 2.10, 95%CI 1.51-2.92). Non-alcohol drinker was associated with low HDL-cholesterol levels (OR 0.72, 95%CI 0.53-0.99, p = 0.04).

CONCLUSIONS

This study found that the prevalence of low HDL-cholesterol was 67.6% and 55.4% for males and females. Male gender, non-alcohol drinker, BMI and central obesity were important risk factors for low HDL-cholesterol in Chinese adults.

Authors+Show Affiliations

Institute of Non-communicable Chronic Diseases, Gansu Center for Disease Control and Prevention, 230 Donggang Western Road, Chengguan District, 730000, Lanzhou, Gansu Province, China.Institute of Non-communicable Chronic Diseases, Gansu Center for Disease Control and Prevention, 230 Donggang Western Road, Chengguan District, 730000, Lanzhou, Gansu Province, China.Institute of Non-communicable Chronic Diseases, Gansu Center for Disease Control and Prevention, 230 Donggang Western Road, Chengguan District, 730000, Lanzhou, Gansu Province, China.Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. Department of Research, Cancer Registry of Norway, Oslo, Norway. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Samfundet Folkhälsan, Helsinki, Finland.Institute of Non-communicable Chronic Diseases, Gansu Center for Disease Control and Prevention, 230 Donggang Western Road, Chengguan District, 730000, Lanzhou, Gansu Province, China.Institute of Non-communicable Chronic Diseases, Gansu Center for Disease Control and Prevention, 230 Donggang Western Road, Chengguan District, 730000, Lanzhou, Gansu Province, China.Institute of Non-communicable Chronic Diseases, Gansu Center for Disease Control and Prevention, 230 Donggang Western Road, Chengguan District, 730000, Lanzhou, Gansu Province, China.Institute of Non-communicable Chronic Diseases, Gansu Center for Disease Control and Prevention, 230 Donggang Western Road, Chengguan District, 730000, Lanzhou, Gansu Province, China.Institute of Non-communicable Chronic Diseases, Gansu Center for Disease Control and Prevention, 230 Donggang Western Road, Chengguan District, 730000, Lanzhou, Gansu Province, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26640891

Citation

Ge, Pengfei, et al. "The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China." PloS One, vol. 10, no. 12, 2015, pp. e0144104.
Ge P, Dong C, Ren X, et al. The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China. PLoS One. 2015;10(12):e0144104.
Ge, P., Dong, C., Ren, X., Weiderpass, E., Zhang, C., Fan, H., Zhang, J., Zhang, Y., & Xi, J. (2015). The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China. PloS One, 10(12), e0144104. https://doi.org/10.1371/journal.pone.0144104
Ge P, et al. The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China. PLoS One. 2015;10(12):e0144104. PubMed PMID: 26640891.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The High Prevalence of Low HDL-Cholesterol Levels and Dyslipidemia in Rural Populations in Northwestern China. AU - Ge,Pengfei, AU - Dong,Caixia, AU - Ren,Xiaolan, AU - Weiderpass,Elisabete, AU - Zhang,Chouji, AU - Fan,Haoqiang, AU - Zhang,Jing, AU - Zhang,Yongrui, AU - Xi,Jinen, Y1 - 2015/12/07/ PY - 2014/03/19/received PY - 2015/11/14/accepted PY - 2015/12/8/entrez PY - 2015/12/8/pubmed PY - 2016/7/7/medline SP - e0144104 EP - e0144104 JF - PloS one JO - PLoS One VL - 10 IS - 12 N2 - BACKGROUND: Dyslipidemia is a major health problem in China and an important modifiable cardiovascular disease (CVD) risk factor. This study aimed to describe the prevalence of dyslipidemia and low high density lipoprotein cholesterol (HDL-cholesterol) and associated risk factors among adults in rural northwest China. METHODS: In a cross-sectional analyses involving 2,980 adults aged >18 years, information on the demographics, cigarette smoking, alcohol consumption, education, and medical history was collected via face-to-face interviews. Blood samples were collected to determine total cholesterol (TC), low-density lipoprotein cholesterol (LDL-cholesterol), and HDL-cholesterol, and triglycerides (TG) levels. RESULTS: The prevalence of high TC, high LDL-cholesterol, low HDL-cholesterol, and high TG were 1.0%, 0.6%, 60.9%, and 13.7%, respectively. TC, LDL-cholesterol, and TG increased with age in females. Elevated TC was more common in females than in males. The prevalence of low HDL-cholesterol was 67.6% in males and 55.4% in females. Current smokers, those with less education, those who were overweight or obese, and those with large waist circumference were more likely to have low HDL-cholesterol (p<0.05). Multivariable regression showed that male gender showed an association with low HDL-cholesterol (OR 2.10, 95%CI 1.68-2.61), age ≥60 years (OR 0.80, 95% CI 0.64-0.99), BMI (BMI = 24-27.9, OR 1.27, 95%CI 1.04-1.54, p = 0.02 and BMI≥28, OR 1.56, 95%CI 1.10-2.20, p = 0.01) and enlarged waist circumference (OR 2.10, 95%CI 1.51-2.92). Non-alcohol drinker was associated with low HDL-cholesterol levels (OR 0.72, 95%CI 0.53-0.99, p = 0.04). CONCLUSIONS: This study found that the prevalence of low HDL-cholesterol was 67.6% and 55.4% for males and females. Male gender, non-alcohol drinker, BMI and central obesity were important risk factors for low HDL-cholesterol in Chinese adults. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26640891/The_High_Prevalence_of_Low_HDL_Cholesterol_Levels_and_Dyslipidemia_in_Rural_Populations_in_Northwestern_China_ L2 - https://dx.plos.org/10.1371/journal.pone.0144104 DB - PRIME DP - Unbound Medicine ER -