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RELEASE AND MUCOADHESION PROPERTIES OF DICLOFENAC MATRIX TABLETS FROM NATURAL AND SYNTHETIC POLYMER BLENDS.
Acta Pol Pharm. 2015 May-Jun; 72(3):559-67.AP

Abstract

The delayed release and mucoadhesive properties of Cedrela gum and hydroxypropylmethylcellulose blend in diclofenac sodium tablet formulations were evaluated. Tablets were prepared by direct compression and the crushing strength and detachment force were found to increase from 74.49 ± 1.22 to 147.25 ± 2.57 N and 0.302 ± 0.36 to 1.141 ± 0.05 N from low to high level of polymers, respectively. The release kinetics followed Korsmeyer-Peppas release and the n varied between 0.834 and 1.273, indicating that the release mechanism shifts from Fickian to super case I (anomalous release). The drug release profile fits a pulsatile-release pattern characterized by a lag time followed by a more or less rapid and complete drug release. The Cedrela gum-hydroxypropylmethylcelluse blend tablets delayed diclofenac release for 2 h and sustained the release for 12 h. The polymer blend delayed drug release in the 0.1 M HCl simulating gastric environment and subsequent release pH 6.8 phosphate buffer.

Authors

Odeniyi MA
No affiliation info available
Khan NH
No affiliation info available
Peh KK
No affiliation info available

MeSH

AdhesivenessDelayed-Action PreparationsDiclofenacHypromellose DerivativesPlant GumsPolymersSolubilityTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26642664

Citation

Odeniyi, Michael A., et al. "RELEASE and MUCOADHESION PROPERTIES of DICLOFENAC MATRIX TABLETS FROM NATURAL and SYNTHETIC POLYMER BLENDS." Acta Poloniae Pharmaceutica, vol. 72, no. 3, 2015, pp. 559-67.
Odeniyi MA, Khan NH, Peh KK. RELEASE AND MUCOADHESION PROPERTIES OF DICLOFENAC MATRIX TABLETS FROM NATURAL AND SYNTHETIC POLYMER BLENDS. Acta Pol Pharm. 2015;72(3):559-67.
Odeniyi, M. A., Khan, N. H., & Peh, K. K. (2015). RELEASE AND MUCOADHESION PROPERTIES OF DICLOFENAC MATRIX TABLETS FROM NATURAL AND SYNTHETIC POLYMER BLENDS. Acta Poloniae Pharmaceutica, 72(3), 559-67.
Odeniyi MA, Khan NH, Peh KK. RELEASE and MUCOADHESION PROPERTIES of DICLOFENAC MATRIX TABLETS FROM NATURAL and SYNTHETIC POLYMER BLENDS. Acta Pol Pharm. 2015 May-Jun;72(3):559-67. PubMed PMID: 26642664.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - RELEASE AND MUCOADHESION PROPERTIES OF DICLOFENAC MATRIX TABLETS FROM NATURAL AND SYNTHETIC POLYMER BLENDS. AU - Odeniyi,Michael A, AU - Khan,Nasir H, AU - Peh,Kok K, PY - 2015/12/9/entrez PY - 2015/12/9/pubmed PY - 2016/1/12/medline SP - 559 EP - 67 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 72 IS - 3 N2 - The delayed release and mucoadhesive properties of Cedrela gum and hydroxypropylmethylcellulose blend in diclofenac sodium tablet formulations were evaluated. Tablets were prepared by direct compression and the crushing strength and detachment force were found to increase from 74.49 ± 1.22 to 147.25 ± 2.57 N and 0.302 ± 0.36 to 1.141 ± 0.05 N from low to high level of polymers, respectively. The release kinetics followed Korsmeyer-Peppas release and the n varied between 0.834 and 1.273, indicating that the release mechanism shifts from Fickian to super case I (anomalous release). The drug release profile fits a pulsatile-release pattern characterized by a lag time followed by a more or less rapid and complete drug release. The Cedrela gum-hydroxypropylmethylcelluse blend tablets delayed diclofenac release for 2 h and sustained the release for 12 h. The polymer blend delayed drug release in the 0.1 M HCl simulating gastric environment and subsequent release pH 6.8 phosphate buffer. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/26642664/RELEASE_AND_MUCOADHESION_PROPERTIES_OF_DICLOFENAC_MATRIX_TABLETS_FROM_NATURAL_AND_SYNTHETIC_POLYMER_BLENDS_ DB - PRIME DP - Unbound Medicine ER -