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Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis.
J Immunol. 2016 Jan 15; 196(2):543-6.JI

Abstract

IL-1β is a proinflammatory cytokine important for local and systemic immunity. However, aberrant production of this cytokine is implicated in pathogenic mechanisms of a number of inflammatory diseases, including Behçet's disease and age-related macular degeneration. In this study, we report the increased secretion of IL-1β in the retina by neutrophils, macrophages, and dendritic cells during ocular inflammation and show that loss of IL-1R signaling confers protection from experimental autoimmune uveitis. Moreover, the amelioration of experimental autoimmune uveitis in Il1r-deficient mice was associated with reduced infiltration of inflammatory cells into the retina and decreased numbers of uveitogenic Th17 cells that mediate uveitis. These findings indicate the possible utility of IL-1R-blocking agents for the treatment of ocular inflammatory diseases.

Authors+Show Affiliations

Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; and.Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892.Molecular Immunology Section, National Eye Institute, National Institutes of Health, Bethesda, MD 20892 wjl@helix.nih.gov egwuaguc@nei.nih.gov.Laboratory of Molecular Immunology and the Immunology Center, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD 20892; and wjl@helix.nih.gov egwuaguc@nei.nih.gov.

Pub Type(s)

Journal Article
Research Support, N.I.H., Intramural

Language

eng

PubMed ID

26643477

Citation

Wan, Chi-Keung, et al. "Cutting Edge: IL-1 Receptor Signaling Is Critical for the Development of Autoimmune Uveitis." Journal of Immunology (Baltimore, Md. : 1950), vol. 196, no. 2, 2016, pp. 543-6.
Wan CK, He C, Sun L, et al. Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis. J Immunol. 2016;196(2):543-6.
Wan, C. K., He, C., Sun, L., Egwuagu, C. E., & Leonard, W. J. (2016). Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis. Journal of Immunology (Baltimore, Md. : 1950), 196(2), 543-6. https://doi.org/10.4049/jimmunol.1502080
Wan CK, et al. Cutting Edge: IL-1 Receptor Signaling Is Critical for the Development of Autoimmune Uveitis. J Immunol. 2016 Jan 15;196(2):543-6. PubMed PMID: 26643477.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cutting Edge: IL-1 Receptor Signaling is Critical for the Development of Autoimmune Uveitis. AU - Wan,Chi-Keung, AU - He,Chang, AU - Sun,Lin, AU - Egwuagu,Charles E, AU - Leonard,Warren J, Y1 - 2015/12/07/ PY - 2015/09/24/received PY - 2015/11/06/accepted PY - 2015/12/9/entrez PY - 2015/12/9/pubmed PY - 2016/5/24/medline SP - 543 EP - 6 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J. Immunol. VL - 196 IS - 2 N2 - IL-1β is a proinflammatory cytokine important for local and systemic immunity. However, aberrant production of this cytokine is implicated in pathogenic mechanisms of a number of inflammatory diseases, including Behçet's disease and age-related macular degeneration. In this study, we report the increased secretion of IL-1β in the retina by neutrophils, macrophages, and dendritic cells during ocular inflammation and show that loss of IL-1R signaling confers protection from experimental autoimmune uveitis. Moreover, the amelioration of experimental autoimmune uveitis in Il1r-deficient mice was associated with reduced infiltration of inflammatory cells into the retina and decreased numbers of uveitogenic Th17 cells that mediate uveitis. These findings indicate the possible utility of IL-1R-blocking agents for the treatment of ocular inflammatory diseases. SN - 1550-6606 UR - https://www.unboundmedicine.com/medline/citation/26643477/Cutting_Edge:_IL_1_Receptor_Signaling_is_Critical_for_the_Development_of_Autoimmune_Uveitis_ L2 - http://www.jimmunol.org/cgi/pmidlookup?view=long&pmid=26643477 DB - PRIME DP - Unbound Medicine ER -