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Toxic effects of indoxacarb enantiomers on the embryonic development and induction of apoptosis in zebrafish larvae (Danio rerio).
Environ Toxicol 2017; 32(1):7-16ET

Abstract

Indoxacarb is a highly potent insecticide widely used to control Lepidoptera insects in vegetable, tea, cotton, and rice fields. It can run off into aquatic environments. It is consisted of two enantiomers. Environmental risks and aquatic toxicity of indoxacarb enantiomers have not been fully investigated. In this study, zebrafish (Danio rerio) embryos were exposed to varying concentrations of (-)-R-indoxacarb and (+)-S-indoxacarb until 96-h post-fertilization (hpf) to assess the embryonic toxicity. (-)-R-indoxacarb was 1.3-fold more toxic than (+)-S-isomer to zebrafish embryos at 96 hpf. (-)-R-indoxacarb exhibited reduction in body length and pericardial edema compared with (+)-S-indoxacarb. (-)-R-indoxacarb decreased the hatching rate sixfold greater than (+)-S-indoxacarb. The rate of pericardial edema induced by (-)-R-indoxacarb was 2.5 times greater than that by (+)-S-indoxacarb. The heart rate of the larvae exposed to (-)-R-indoxacarb was 30% lower than that to (+)-S-indoxacarb. In addition, exposure to the chiral isomers resulted in significant increases in apoptosis; interestingly (-)-R-indoxacarb induced apoptosis in the heart area, whereas (+)-S-indoxacarb induced apoptosis in the head area. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 7-16, 2017.

Authors+Show Affiliations

Department of Agricultural Product Quality and Safety, College of Environment and Plant Protection, Hainan University, Haikou, 570228, China.Department of Agricultural Product Quality and Safety, College of Environment and Plant Protection, Hainan University, Haikou, 570228, China.Department of Agricultural Product Quality and Safety, College of Environment and Plant Protection, Hainan University, Haikou, 570228, China.Department of Agricultural Product Quality and Safety, College of Environment and Plant Protection, Hainan University, Haikou, 570228, China.Department of Agricultural Product Quality and Safety, College of Environment and Plant Protection, Hainan University, Haikou, 570228, China.Department of Molecular Biosciences and Bioengineering, University of Hawaii at Manoa, Honolulu, Hawaii, 96822, USA.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26646157

Citation

Fan, Yongmei, et al. "Toxic Effects of Indoxacarb Enantiomers On the Embryonic Development and Induction of Apoptosis in Zebrafish Larvae (Danio Rerio)." Environmental Toxicology, vol. 32, no. 1, 2017, pp. 7-16.
Fan Y, Feng Q, Lai K, et al. Toxic effects of indoxacarb enantiomers on the embryonic development and induction of apoptosis in zebrafish larvae (Danio rerio). Environ Toxicol. 2017;32(1):7-16.
Fan, Y., Feng, Q., Lai, K., Huang, W., Zhang, C., & Li, Q. X. (2017). Toxic effects of indoxacarb enantiomers on the embryonic development and induction of apoptosis in zebrafish larvae (Danio rerio). Environmental Toxicology, 32(1), pp. 7-16. doi:10.1002/tox.22207.
Fan Y, et al. Toxic Effects of Indoxacarb Enantiomers On the Embryonic Development and Induction of Apoptosis in Zebrafish Larvae (Danio Rerio). Environ Toxicol. 2017;32(1):7-16. PubMed PMID: 26646157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Toxic effects of indoxacarb enantiomers on the embryonic development and induction of apoptosis in zebrafish larvae (Danio rerio). AU - Fan,Yongmei, AU - Feng,Qing, AU - Lai,Kehua, AU - Huang,Weikang, AU - Zhang,Chenghui, AU - Li,Qing X, Y1 - 2015/12/09/ PY - 2015/07/13/received PY - 2015/09/18/revised PY - 2015/09/26/accepted PY - 2015/12/10/pubmed PY - 2017/3/3/medline PY - 2015/12/10/entrez KW - TUNEL KW - apoptosis KW - aquatic toxicity KW - chiral indoxacarb KW - zebrafish SP - 7 EP - 16 JF - Environmental toxicology JO - Environ. Toxicol. VL - 32 IS - 1 N2 - Indoxacarb is a highly potent insecticide widely used to control Lepidoptera insects in vegetable, tea, cotton, and rice fields. It can run off into aquatic environments. It is consisted of two enantiomers. Environmental risks and aquatic toxicity of indoxacarb enantiomers have not been fully investigated. In this study, zebrafish (Danio rerio) embryos were exposed to varying concentrations of (-)-R-indoxacarb and (+)-S-indoxacarb until 96-h post-fertilization (hpf) to assess the embryonic toxicity. (-)-R-indoxacarb was 1.3-fold more toxic than (+)-S-isomer to zebrafish embryos at 96 hpf. (-)-R-indoxacarb exhibited reduction in body length and pericardial edema compared with (+)-S-indoxacarb. (-)-R-indoxacarb decreased the hatching rate sixfold greater than (+)-S-indoxacarb. The rate of pericardial edema induced by (-)-R-indoxacarb was 2.5 times greater than that by (+)-S-indoxacarb. The heart rate of the larvae exposed to (-)-R-indoxacarb was 30% lower than that to (+)-S-indoxacarb. In addition, exposure to the chiral isomers resulted in significant increases in apoptosis; interestingly (-)-R-indoxacarb induced apoptosis in the heart area, whereas (+)-S-indoxacarb induced apoptosis in the head area. © 2015 Wiley Periodicals, Inc. Environ Toxicol 32: 7-16, 2017. SN - 1522-7278 UR - https://www.unboundmedicine.com/medline/citation/26646157/Toxic_effects_of_indoxacarb_enantiomers_on_the_embryonic_development_and_induction_of_apoptosis_in_zebrafish_larvae__Danio_rerio__ L2 - https://doi.org/10.1002/tox.22207 DB - PRIME DP - Unbound Medicine ER -