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The role of the new reproductive technologies including IVF and GIFT in endometriosis.
Obstet Gynecol Clin North Am 1989; 16(1):179-91OG

Abstract

In the context of the pathophysiology of endometriosis, the technology of IVF-ET and GIFT appears to offer a promising alternative for infertility associated with endometriosis in situations refractory to conventional medical or surgical therapy. The success rate of IVF with respect to follicular response, oocyte recovery, fertilization rate, and pregnancy rate in mild-to-moderate (stages I to II) disease is comparable to patients with tubal disease. However, compromise of oocyte recovery and fertilization appears to be present in severe-extensive cases (stages III to IV) implying an impairment of reproductive potential in advanced disease. In all stages of endometriosis, prior therapy, either medical or surgical, offers the best prognosis for an IVF or GIFT attempt. Surgical therapy with operative endoscopy at the time of oocyte retrieval offers a reasonable prognosis for treatment-independent pregnancy in cases of active endometriosis. The GIFT procedure bypasses an unfavorable peritoneal environment in stages I to II endometriosis without anatomic distortion or compromise of fallopian tube function. Pretreatment with GnRH analogues prior to ovulation induction is valuable in suppression of active disease as well as in inducing improved homogeneity of follicular response in IVF or GIFT cycles.

Authors+Show Affiliations

Department of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Baltimore, Maryland.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

2664617

Citation

Damewood, M D.. "The Role of the New Reproductive Technologies Including IVF and GIFT in Endometriosis." Obstetrics and Gynecology Clinics of North America, vol. 16, no. 1, 1989, pp. 179-91.
Damewood MD. The role of the new reproductive technologies including IVF and GIFT in endometriosis. Obstet Gynecol Clin North Am. 1989;16(1):179-91.
Damewood, M. D. (1989). The role of the new reproductive technologies including IVF and GIFT in endometriosis. Obstetrics and Gynecology Clinics of North America, 16(1), pp. 179-91.
Damewood MD. The Role of the New Reproductive Technologies Including IVF and GIFT in Endometriosis. Obstet Gynecol Clin North Am. 1989;16(1):179-91. PubMed PMID: 2664617.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of the new reproductive technologies including IVF and GIFT in endometriosis. A1 - Damewood,M D, PY - 1989/3/1/pubmed PY - 1989/3/1/medline PY - 1989/3/1/entrez SP - 179 EP - 91 JF - Obstetrics and gynecology clinics of North America JO - Obstet. Gynecol. Clin. North Am. VL - 16 IS - 1 N2 - In the context of the pathophysiology of endometriosis, the technology of IVF-ET and GIFT appears to offer a promising alternative for infertility associated with endometriosis in situations refractory to conventional medical or surgical therapy. The success rate of IVF with respect to follicular response, oocyte recovery, fertilization rate, and pregnancy rate in mild-to-moderate (stages I to II) disease is comparable to patients with tubal disease. However, compromise of oocyte recovery and fertilization appears to be present in severe-extensive cases (stages III to IV) implying an impairment of reproductive potential in advanced disease. In all stages of endometriosis, prior therapy, either medical or surgical, offers the best prognosis for an IVF or GIFT attempt. Surgical therapy with operative endoscopy at the time of oocyte retrieval offers a reasonable prognosis for treatment-independent pregnancy in cases of active endometriosis. The GIFT procedure bypasses an unfavorable peritoneal environment in stages I to II endometriosis without anatomic distortion or compromise of fallopian tube function. Pretreatment with GnRH analogues prior to ovulation induction is valuable in suppression of active disease as well as in inducing improved homogeneity of follicular response in IVF or GIFT cycles. SN - 0889-8545 UR - https://www.unboundmedicine.com/medline/citation/2664617/The_role_of_the_new_reproductive_technologies_including_IVF_and_GIFT_in_endometriosis_ L2 - http://www.diseaseinfosearch.org/result/2537 DB - PRIME DP - Unbound Medicine ER -