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MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes.
Eur J Endocrinol. 2016 May; 174(5):R175-87.EJ

Abstract

Obesity is the main risk factor for type 2 diabetes (T2D). Studies performed over the last 20 years have identified inflammation as the most important link between these two diseases. During the development of obesity, there is activation of subclinical inflammatory activity in tissues involved in metabolism and energy homeostasis. Intracellular serine/threonine kinases activated in response to inflammatory factors can catalyse the inhibitory phosphorylation of key proteins of the insulin-signalling pathway, leading to insulin resistance. Moreover, during the progression of obesity and insulin resistance, the pancreatic islets are also affected by inflammation, contributing to β-cell failure and leading to the onset of T2D. In this review, we will present the main mechanisms involved in the activation of obesity-associated metabolic inflammation and discuss potential therapeutic opportunities that can be developed to treat obesity-associated metabolic diseases.

Authors+Show Affiliations

Laboratory of Cell SignalingApplied Sciences FacultyUniversity of Campinas, 13084-970 Campinas, São Paulo, Brazil.Laboratory of Cell SignalingApplied Sciences FacultyUniversity of Campinas, 13084-970 Campinas, São Paulo, Brazil.Laboratory of Cell SignalingApplied Sciences FacultyUniversity of Campinas, 13084-970 Campinas, São Paulo, Brazil lavelloso.unicamp@gmail.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26646937

Citation

Coope, Andressa, et al. "MECHANISMS in ENDOCRINOLOGY: Metabolic and Inflammatory Pathways On the Pathogenesis of Type 2 Diabetes." European Journal of Endocrinology, vol. 174, no. 5, 2016, pp. R175-87.
Coope A, Torsoni AS, Velloso LA. MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes. Eur J Endocrinol. 2016;174(5):R175-87.
Coope, A., Torsoni, A. S., & Velloso, L. A. (2016). MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes. European Journal of Endocrinology, 174(5), R175-87. https://doi.org/10.1530/EJE-15-1065
Coope A, Torsoni AS, Velloso LA. MECHANISMS in ENDOCRINOLOGY: Metabolic and Inflammatory Pathways On the Pathogenesis of Type 2 Diabetes. Eur J Endocrinol. 2016;174(5):R175-87. PubMed PMID: 26646937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MECHANISMS IN ENDOCRINOLOGY: Metabolic and inflammatory pathways on the pathogenesis of type 2 diabetes. AU - Coope,Andressa, AU - Torsoni,Adriana S, AU - Velloso,Licio A, Y1 - 2015/12/08/ PY - 2015/10/30/received PY - 2015/12/07/accepted PY - 2015/12/10/entrez PY - 2015/12/10/pubmed PY - 2016/8/10/medline SP - R175 EP - 87 JF - European journal of endocrinology JO - Eur J Endocrinol VL - 174 IS - 5 N2 - Obesity is the main risk factor for type 2 diabetes (T2D). Studies performed over the last 20 years have identified inflammation as the most important link between these two diseases. During the development of obesity, there is activation of subclinical inflammatory activity in tissues involved in metabolism and energy homeostasis. Intracellular serine/threonine kinases activated in response to inflammatory factors can catalyse the inhibitory phosphorylation of key proteins of the insulin-signalling pathway, leading to insulin resistance. Moreover, during the progression of obesity and insulin resistance, the pancreatic islets are also affected by inflammation, contributing to β-cell failure and leading to the onset of T2D. In this review, we will present the main mechanisms involved in the activation of obesity-associated metabolic inflammation and discuss potential therapeutic opportunities that can be developed to treat obesity-associated metabolic diseases. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/26646937/MECHANISMS_IN_ENDOCRINOLOGY:_Metabolic_and_inflammatory_pathways_on_the_pathogenesis_of_type_2_diabetes_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-15-1065 DB - PRIME DP - Unbound Medicine ER -
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