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Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model.
Int J Mol Med. 2015 Nov; 36(5):1369-76.IJ

Abstract

Parkinson's disease (PD) is second only to Alzheimer's disease as the most common and debilitating age-associated neurodegenerative disorder. Currently, no therapy has been shown to unequivocally retard or arrest the progression of the disease. The aim of the present study was to investigate the protective effect of piperine on the 1-methyl-4-phenyl-1,2,3,6‑tetrahydropyridine (MPTP)-induced Parkinson's mouse model. For MPTP treatment, the animals received repeated intraperitoneal injections (i.p.) of MPTP (30 mg/kg) solution for 7 days. Piperine (10 mg/kg) was administered orally for 15 days including 8 days of pretreatment. Motor behavior analysis was conducted with the rotarod test. The Morris water maze (MWM) was used to assess the cognitive learning ability of the mice. A histological examination was subsequently conducted. The results ddemonstrate that piperine treatment attenuated MPTP-induced deficits in motor coordination and cognitive functioning. Piperine also prevented MPTP-induced decreases in the number of tyrosine hydroxylase-positive cells in the substantia nigra. Additionally, piperine reduced the number of activated microglia, expression of cytokine IL-1β, and oxidative stress following MPTP treatment. An anti-apoptotic property of piperine was identified by maintaining the balance of Bcl-2/Bax. In conclusion, the results show that piperine exerts a protective effect on dopaminergic neurons via antioxidant, anti-apoptotic, and anti-inflammatory mechanisms in an MPTP-induced mouse model of PD. Thus, piperine is a potential therapeutic treatment for PD.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Yang W
Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Chen YH
Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.
Liu H
Faculty of Pharmacy, Bengbu Medical College, Bengbu, Anhui 233030, P.R. China.
Qu HD
Department of Neurology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China.

MeSH

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridineAlkaloidsAnimalsAnti-Inflammatory AgentsApoptosisBenzodioxolesDisease Models, AnimalDopaminergic NeuronsInterleukin-1betaMaleMiceMice, Inbred C57BLMotor ActivityNeuroprotective AgentsOxidative StressParkinson DiseasePiperidinesPolyunsaturated AlkamidesRotarod Performance TestSubstantia NigraTyrosine 3-Monooxygenase

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26648012

Citation

Yang, Wei, et al. "Neuroprotective Effects of Piperine On the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's Disease Mouse Model." International Journal of Molecular Medicine, vol. 36, no. 5, 2015, pp. 1369-76.
Yang W, Chen YH, Liu H, et al. Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model. Int J Mol Med. 2015;36(5):1369-76.
Yang, W., Chen, Y. H., Liu, H., & Qu, H. D. (2015). Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model. International Journal of Molecular Medicine, 36(5), 1369-76. https://doi.org/10.3892/ijmm.2015.2356
Yang W, et al. Neuroprotective Effects of Piperine On the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's Disease Mouse Model. Int J Mol Med. 2015;36(5):1369-76. PubMed PMID: 26648012.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotective effects of piperine on the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease mouse model. AU - Yang,Wei, AU - Chen,Yu-Hua, AU - Liu,Hao, AU - Qu,Hong-Dang, Y1 - 2015/09/28/ PY - 2015/03/13/received PY - 2015/09/23/accepted PY - 2015/12/10/entrez PY - 2015/12/10/pubmed PY - 2016/9/7/medline SP - 1369 EP - 76 JF - International journal of molecular medicine JO - Int J Mol Med VL - 36 IS - 5 N2 - Parkinson's disease (PD) is second only to Alzheimer's disease as the most common and debilitating age-associated neurodegenerative disorder. Currently, no therapy has been shown to unequivocally retard or arrest the progression of the disease. The aim of the present study was to investigate the protective effect of piperine on the 1-methyl-4-phenyl-1,2,3,6‑tetrahydropyridine (MPTP)-induced Parkinson's mouse model. For MPTP treatment, the animals received repeated intraperitoneal injections (i.p.) of MPTP (30 mg/kg) solution for 7 days. Piperine (10 mg/kg) was administered orally for 15 days including 8 days of pretreatment. Motor behavior analysis was conducted with the rotarod test. The Morris water maze (MWM) was used to assess the cognitive learning ability of the mice. A histological examination was subsequently conducted. The results ddemonstrate that piperine treatment attenuated MPTP-induced deficits in motor coordination and cognitive functioning. Piperine also prevented MPTP-induced decreases in the number of tyrosine hydroxylase-positive cells in the substantia nigra. Additionally, piperine reduced the number of activated microglia, expression of cytokine IL-1β, and oxidative stress following MPTP treatment. An anti-apoptotic property of piperine was identified by maintaining the balance of Bcl-2/Bax. In conclusion, the results show that piperine exerts a protective effect on dopaminergic neurons via antioxidant, anti-apoptotic, and anti-inflammatory mechanisms in an MPTP-induced mouse model of PD. Thus, piperine is a potential therapeutic treatment for PD. SN - 1791-244X UR - https://www.unboundmedicine.com/medline/citation/26648012/Neuroprotective_effects_of_piperine_on_the_1_methyl_4_phenyl_1236_tetrahydropyridine_induced_Parkinson's_disease_mouse_model_ DB - PRIME DP - Unbound Medicine ER -