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Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging.
Eur J Clin Nutr. 2016 Mar; 70(3):380-5.EJ

Abstract

BACKGROUND/OBJECTIVES

Depression can decrease quality of life and affect health outcomes in older population. We investigated whether different intake levels of folate, vitamin B6 and B12 were associated with a 3-year depression incidence among generally healthy, community-dwelling older men and women.

SUBJECTS/METHODS

Participants in the Québec Longitudinal Study on Nutrition and Aging (NuAge), free of depression (that is, 30-item Geriatric Depression Scale (GDS) <11) at baseline (N=1368; 74 ± 4 years old; 50.5% women), were screened annually for incident depression (GDS ⩾ 11) or antidepressant medication. Tertiles of intakes (food only and food+supplements) were obtained from the mean of three non-consecutive 24-h recalls at baseline. Sex-stratified multiple logistic regression models were adjusted for age, physical activity, physical functioning, stressful life events and total energy intake.

RESULTS

Over 3 years, 170 participants were identified as depressed. Women in the highest tertile of B6 intake from food were 43% less likely to become depressed when adjusting for demographic and health factors (multivariate odds ratio (OR) 0.57, 95% confidence interval (CI) 0.39-0.96), but adjustment for energy intake attenuated the effect. Men in the highest tertile of dietary B12 intake had decreased risk of depression (energy-adjusted multivariate OR 0.42, 95% CI 0.20-0.90). No other association was observed.

CONCLUSIONS

This study provides some evidence of decreased depression risk among women with higher intakes of vitamin B6 from food, which was dependent on total energy intake, and among men with higher intakes of B12 from food, independently of energy intake.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

Gougeon L
Department of Human Nutrition, St Francis Xavier University, Antigonish, Nova Scotia, Canada. School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada.
Payette H
Research Center on Aging, CIUSSS de l'Estrie-CHUS, Sherbrooke, Quebec, Canada. Department of Science and Community Health, Faculty of Medicine and Health Sciences, University of Sherbrooke, Sherbrooke, Quebec, Canada.
Morais JA
Department of Experimental Medicine, Division of Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, Canada.
Gaudreau P
Centre Hospitalier de l'Université de Montréal Research Center, Montreal, Quebec, Canada. Département de Médecine, Université de Montréal, Montréal, Quebec, Canada.
Shatenstein B
Département de Nutrition, Université de Montréal, Montréal, Quebec, Canada. Centre de Recherche, Institut Universitaire de Gériatrie de Montréal, CIUSSS du Centre-est-de-l'Île-de-Montréal, Montreal, Quebec, Canada.
Gray-Donald K
School of Dietetics and Human Nutrition, McGill University, Ste-Anne-de-Bellevue, Quebec, Canada.

MeSH

AgedDepressionDietary SupplementsEnergy IntakeFemaleFolic AcidHomes for the AgedHumansIncidenceLogistic ModelsLongitudinal StudiesMaleNutrition AssessmentQuality of LifeQuebecRisk FactorsVitamin B 12Vitamin B 6

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26648330

Citation

Gougeon, L, et al. "Intakes of Folate, Vitamin B6 and B12 and Risk of Depression in Community-dwelling Older Adults: the Quebec Longitudinal Study On Nutrition and Aging." European Journal of Clinical Nutrition, vol. 70, no. 3, 2016, pp. 380-5.
Gougeon L, Payette H, Morais JA, et al. Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging. Eur J Clin Nutr. 2016;70(3):380-5.
Gougeon, L., Payette, H., Morais, J. A., Gaudreau, P., Shatenstein, B., & Gray-Donald, K. (2016). Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging. European Journal of Clinical Nutrition, 70(3), 380-5. https://doi.org/10.1038/ejcn.2015.202
Gougeon L, et al. Intakes of Folate, Vitamin B6 and B12 and Risk of Depression in Community-dwelling Older Adults: the Quebec Longitudinal Study On Nutrition and Aging. Eur J Clin Nutr. 2016;70(3):380-5. PubMed PMID: 26648330.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intakes of folate, vitamin B6 and B12 and risk of depression in community-dwelling older adults: the Quebec Longitudinal Study on Nutrition and Aging. AU - Gougeon,L, AU - Payette,H, AU - Morais,J A, AU - Gaudreau,P, AU - Shatenstein,B, AU - Gray-Donald,K, Y1 - 2015/12/09/ PY - 2015/08/18/received PY - 2015/10/09/revised PY - 2015/11/06/accepted PY - 2015/12/10/entrez PY - 2015/12/10/pubmed PY - 2016/12/23/medline SP - 380 EP - 5 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 70 IS - 3 N2 - BACKGROUND/OBJECTIVES: Depression can decrease quality of life and affect health outcomes in older population. We investigated whether different intake levels of folate, vitamin B6 and B12 were associated with a 3-year depression incidence among generally healthy, community-dwelling older men and women. SUBJECTS/METHODS: Participants in the Québec Longitudinal Study on Nutrition and Aging (NuAge), free of depression (that is, 30-item Geriatric Depression Scale (GDS) <11) at baseline (N=1368; 74 ± 4 years old; 50.5% women), were screened annually for incident depression (GDS ⩾ 11) or antidepressant medication. Tertiles of intakes (food only and food+supplements) were obtained from the mean of three non-consecutive 24-h recalls at baseline. Sex-stratified multiple logistic regression models were adjusted for age, physical activity, physical functioning, stressful life events and total energy intake. RESULTS: Over 3 years, 170 participants were identified as depressed. Women in the highest tertile of B6 intake from food were 43% less likely to become depressed when adjusting for demographic and health factors (multivariate odds ratio (OR) 0.57, 95% confidence interval (CI) 0.39-0.96), but adjustment for energy intake attenuated the effect. Men in the highest tertile of dietary B12 intake had decreased risk of depression (energy-adjusted multivariate OR 0.42, 95% CI 0.20-0.90). No other association was observed. CONCLUSIONS: This study provides some evidence of decreased depression risk among women with higher intakes of vitamin B6 from food, which was dependent on total energy intake, and among men with higher intakes of B12 from food, independently of energy intake. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/26648330/Intakes_of_folate_vitamin_B6_and_B12_and_risk_of_depression_in_community_dwelling_older_adults:_the_Quebec_Longitudinal_Study_on_Nutrition_and_Aging_ DB - PRIME DP - Unbound Medicine ER -