Tags

Type your tag names separated by a space and hit enter

Reproductive toxicity of binary and ternary mixture combinations of nickel, zinc, and lead to Ceriodaphnia dubia is best predicted with the independent action model.
Environ Toxicol Chem. 2016 07; 35(7):1796-805.ET

Abstract

Metals occur as mixtures in the environment. Risk assessment procedures for metals currently lack a framework to incorporate chronic metal mixture toxicity. In the present study, the toxicity of binary and ternary mixture combinations of Ni, Zn, and Pb was investigated in 3 large-scale experiments using the standard chronic (7-d) Ceriodaphnia dubia reproductive toxicity test. These metals were selected because of anticipated differences in mode of action. The toxicity of the metals in most mixtures, expressed as either free metal ion activities or as dissolved metal concentrations, were antagonistic relative to the concentration addition model, whereas no significant (p < 0.05) interactive effects were observed relative to the independent action model. The only exception was the binary Pb-Zn mixture, for which mixture effects were noninteractive based on the dissolved concentrations, but antagonistic based on free ion activities all relative to the independent action model. Overall, the independent action model fitted the observed toxicity better than the concentration addition model, which is consistent with the different modes of action of these metals. The concentration addition model mostly overestimated toxicity. Finally, the present study warns against extrapolation of the type of interactive effects between species, even when they are closely related. Environ Toxicol Chem 2016;35:1796-1805. © 2015 SETAC.

Authors+Show Affiliations

Faculty of Bioscience Engineering, GhenToxLab, Ghent University, Ghent, Belgium.Faculty of Bioscience Engineering, GhenToxLab, Ghent University, Ghent, Belgium.Laboratory for Ecophysiology, Biochemistry, and Toxicology, University of Antwerp, Antwerp, Belgium.Division Soil and Water Management, KULeuven, Leuven, Belgium.Faculty of Bioscience Engineering, GhenToxLab, Ghent University, Ghent, Belgium.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26648335

Citation

Nys, Charlotte, et al. "Reproductive Toxicity of Binary and Ternary Mixture Combinations of Nickel, Zinc, and Lead to Ceriodaphnia Dubia Is Best Predicted With the Independent Action Model." Environmental Toxicology and Chemistry, vol. 35, no. 7, 2016, pp. 1796-805.
Nys C, Janssen CR, Blust R, et al. Reproductive toxicity of binary and ternary mixture combinations of nickel, zinc, and lead to Ceriodaphnia dubia is best predicted with the independent action model. Environ Toxicol Chem. 2016;35(7):1796-805.
Nys, C., Janssen, C. R., Blust, R., Smolders, E., & De Schamphelaere, K. A. (2016). Reproductive toxicity of binary and ternary mixture combinations of nickel, zinc, and lead to Ceriodaphnia dubia is best predicted with the independent action model. Environmental Toxicology and Chemistry, 35(7), 1796-805. https://doi.org/10.1002/etc.3332
Nys C, et al. Reproductive Toxicity of Binary and Ternary Mixture Combinations of Nickel, Zinc, and Lead to Ceriodaphnia Dubia Is Best Predicted With the Independent Action Model. Environ Toxicol Chem. 2016;35(7):1796-805. PubMed PMID: 26648335.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproductive toxicity of binary and ternary mixture combinations of nickel, zinc, and lead to Ceriodaphnia dubia is best predicted with the independent action model. AU - Nys,Charlotte, AU - Janssen,Colin R, AU - Blust,Ronny, AU - Smolders,Erik, AU - De Schamphelaere,Karel A C, Y1 - 2016/03/31/ PY - 2015/09/21/received PY - 2015/11/03/revised PY - 2015/12/08/accepted PY - 2015/12/10/entrez PY - 2015/12/10/pubmed PY - 2017/6/22/medline KW - Daphnia KW - Freshwater KW - Metals KW - Mixture toxicity KW - Risk assessment SP - 1796 EP - 805 JF - Environmental toxicology and chemistry JO - Environ Toxicol Chem VL - 35 IS - 7 N2 - Metals occur as mixtures in the environment. Risk assessment procedures for metals currently lack a framework to incorporate chronic metal mixture toxicity. In the present study, the toxicity of binary and ternary mixture combinations of Ni, Zn, and Pb was investigated in 3 large-scale experiments using the standard chronic (7-d) Ceriodaphnia dubia reproductive toxicity test. These metals were selected because of anticipated differences in mode of action. The toxicity of the metals in most mixtures, expressed as either free metal ion activities or as dissolved metal concentrations, were antagonistic relative to the concentration addition model, whereas no significant (p < 0.05) interactive effects were observed relative to the independent action model. The only exception was the binary Pb-Zn mixture, for which mixture effects were noninteractive based on the dissolved concentrations, but antagonistic based on free ion activities all relative to the independent action model. Overall, the independent action model fitted the observed toxicity better than the concentration addition model, which is consistent with the different modes of action of these metals. The concentration addition model mostly overestimated toxicity. Finally, the present study warns against extrapolation of the type of interactive effects between species, even when they are closely related. Environ Toxicol Chem 2016;35:1796-1805. © 2015 SETAC. SN - 1552-8618 UR - https://www.unboundmedicine.com/medline/citation/26648335/Reproductive_toxicity_of_binary_and_ternary_mixture_combinations_of_nickel_zinc_and_lead_to_Ceriodaphnia_dubia_is_best_predicted_with_the_independent_action_model_ DB - PRIME DP - Unbound Medicine ER -