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[Signaling molecules in the brain and epigenetic factors in neurodegenerative and mental disorders].
Zh Nevrol Psikhiatr Im S S Korsakova. 2015; 115(10):102-110.ZN

Abstract

The literature on a role of signaling molecules in the organization of memory and cognitive functions is analyzed basing on mechanisms of memory physiology determined by a complex of biochemical processes initiated by the transmission of the signal to the synapse and completed by the synthesis of functionally significant molecules in the neuronal genetic apparatus. The center of these processes is a coordinated system of signal transduction, transcription, epigenetic and neurotrophic molecules. The dissonance of signal mechanisms is a prime cause of memory impairment and cognitive dysfunction as social maladaptation factors. The results of experimental and clinical studies of a role of the multilevel signaling system in age-related, neurodegenerative (Alzheimer’s disease) and mental (depression) disorders are discussed. At the same time, signaling molecules may be considered as particular targets for new therapeutic approaches.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Gomazkov OA
Orekhovich Research Institute of Biomedical Chemistry, Moscow.

MeSH

Alzheimer DiseaseBrainCognition DisordersDepressionEpigenesis, GeneticHumansMemoryMemory DisordersMental DisordersNeurodegenerative DiseasesSignal TransductionSynapses

Pub Type(s)

English Abstract
Journal Article
Review

Language

rus

PubMed ID

26649375

Citation

Gomazkov, O A.. "[Signaling Molecules in the Brain and Epigenetic Factors in Neurodegenerative and Mental Disorders]." Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova, vol. 115, no. 10, 2015, pp. 102-110.
Gomazkov OA. [Signaling molecules in the brain and epigenetic factors in neurodegenerative and mental disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(10):102-110.
Gomazkov, O. A. (2015). [Signaling molecules in the brain and epigenetic factors in neurodegenerative and mental disorders]. Zhurnal Nevrologii I Psikhiatrii Imeni S.S. Korsakova, 115(10), 102-110. https://doi.org/10.17116/jnevro2015115101102-110
Gomazkov OA. [Signaling Molecules in the Brain and Epigenetic Factors in Neurodegenerative and Mental Disorders]. Zh Nevrol Psikhiatr Im S S Korsakova. 2015;115(10):102-110. PubMed PMID: 26649375.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Signaling molecules in the brain and epigenetic factors in neurodegenerative and mental disorders]. A1 - Gomazkov,O A, PY - 2015/12/10/entrez PY - 2015/12/10/pubmed PY - 2016/3/5/medline SP - 102 EP - 110 JF - Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova JO - Zh Nevrol Psikhiatr Im S S Korsakova VL - 115 IS - 10 N2 - The literature on a role of signaling molecules in the organization of memory and cognitive functions is analyzed basing on mechanisms of memory physiology determined by a complex of biochemical processes initiated by the transmission of the signal to the synapse and completed by the synthesis of functionally significant molecules in the neuronal genetic apparatus. The center of these processes is a coordinated system of signal transduction, transcription, epigenetic and neurotrophic molecules. The dissonance of signal mechanisms is a prime cause of memory impairment and cognitive dysfunction as social maladaptation factors. The results of experimental and clinical studies of a role of the multilevel signaling system in age-related, neurodegenerative (Alzheimer’s disease) and mental (depression) disorders are discussed. At the same time, signaling molecules may be considered as particular targets for new therapeutic approaches. SN - 1997-7298 UR - https://www.unboundmedicine.com/medline/citation/26649375/[Signaling_molecules_in_the_brain_and_epigenetic_factors_in_neurodegenerative_and_mental_disorders]_ DB - PRIME DP - Unbound Medicine ER -