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Boron doped diamond sensor for sensitive determination of metronidazole: Mechanistic and analytical study by cyclic voltammetry and square wave voltammetry.
Mater Sci Eng C Mater Biol Appl. 2016 Feb; 59:604-610.MS

Abstract

The performance of boron-doped diamond (BDD) electrode for the detection of metronidazole (MTZ) as the most important drug of the group of 5-nitroimidazole was proven using cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques. A comparison study between BDD, glassy carbon and silver electrodes on the electrochemical response was carried out. The process is pH-dependent. In neutral and alkaline media, one irreversible reduction peak related to the hydroxylamine derivative formation was registered, involving a total of four electrons. In acidic medium, a prepeak appears probably related to the adsorption affinity of hydroxylamine at the electrode surface. The BDD electrode showed higher sensitivity and reproducibility analytical response, compared with the other electrodes. The higher reduction peak current was registered at pH11. Under optimal conditions, a linear analytical curve was obtained for the MTZ concentration in the range of 0.2-4.2μmolL(-1), with a detection limit of 0.065μmolL(-1).

Authors+Show Affiliations

Electrochemistry and Environmental Laboratory, Department of Materials Engineering, National Engineering School of Sfax, University of Sfax, B.P. 1173, 3038 Sfax, Tunisia. Electronic address: hbelhadjammar@yahoo.fr.Electrochemistry and Environmental Laboratory, Department of Materials Engineering, National Engineering School of Sfax, University of Sfax, B.P. 1173, 3038 Sfax, Tunisia.Electrochemistry and Environmental Laboratory, Department of Materials Engineering, National Engineering School of Sfax, University of Sfax, B.P. 1173, 3038 Sfax, Tunisia.Electrochemistry and Environmental Laboratory, Department of Materials Engineering, National Engineering School of Sfax, University of Sfax, B.P. 1173, 3038 Sfax, Tunisia.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26652413

Citation

Ammar, Hafedh Belhadj, et al. "Boron Doped Diamond Sensor for Sensitive Determination of Metronidazole: Mechanistic and Analytical Study By Cyclic Voltammetry and Square Wave Voltammetry." Materials Science & Engineering. C, Materials for Biological Applications, vol. 59, 2016, pp. 604-610.
Ammar HB, Brahim MB, Abdelhédi R, et al. Boron doped diamond sensor for sensitive determination of metronidazole: Mechanistic and analytical study by cyclic voltammetry and square wave voltammetry. Mater Sci Eng C Mater Biol Appl. 2016;59:604-610.
Ammar, H. B., Brahim, M. B., Abdelhédi, R., & Samet, Y. (2016). Boron doped diamond sensor for sensitive determination of metronidazole: Mechanistic and analytical study by cyclic voltammetry and square wave voltammetry. Materials Science & Engineering. C, Materials for Biological Applications, 59, 604-610. https://doi.org/10.1016/j.msec.2015.10.025
Ammar HB, et al. Boron Doped Diamond Sensor for Sensitive Determination of Metronidazole: Mechanistic and Analytical Study By Cyclic Voltammetry and Square Wave Voltammetry. Mater Sci Eng C Mater Biol Appl. 2016;59:604-610. PubMed PMID: 26652413.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Boron doped diamond sensor for sensitive determination of metronidazole: Mechanistic and analytical study by cyclic voltammetry and square wave voltammetry. AU - Ammar,Hafedh Belhadj, AU - Brahim,Mabrouk Ben, AU - Abdelhédi,Ridha, AU - Samet,Youssef, Y1 - 2015/10/22/ PY - 2015/07/02/received PY - 2015/09/10/revised PY - 2015/10/09/accepted PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2016/9/22/medline KW - Analytical KW - Boron doped diamond KW - Metronidazole KW - Square wave voltammetry SP - 604 EP - 610 JF - Materials science & engineering. C, Materials for biological applications JO - Mater Sci Eng C Mater Biol Appl VL - 59 N2 - The performance of boron-doped diamond (BDD) electrode for the detection of metronidazole (MTZ) as the most important drug of the group of 5-nitroimidazole was proven using cyclic voltammetry (CV) and square wave voltammetry (SWV) techniques. A comparison study between BDD, glassy carbon and silver electrodes on the electrochemical response was carried out. The process is pH-dependent. In neutral and alkaline media, one irreversible reduction peak related to the hydroxylamine derivative formation was registered, involving a total of four electrons. In acidic medium, a prepeak appears probably related to the adsorption affinity of hydroxylamine at the electrode surface. The BDD electrode showed higher sensitivity and reproducibility analytical response, compared with the other electrodes. The higher reduction peak current was registered at pH11. Under optimal conditions, a linear analytical curve was obtained for the MTZ concentration in the range of 0.2-4.2μmolL(-1), with a detection limit of 0.065μmolL(-1). SN - 1873-0191 UR - https://www.unboundmedicine.com/medline/citation/26652413/Boron_doped_diamond_sensor_for_sensitive_determination_of_metronidazole:_Mechanistic_and_analytical_study_by_cyclic_voltammetry_and_square_wave_voltammetry_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0928-4931(15)30455-0 DB - PRIME DP - Unbound Medicine ER -