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Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise.
Neuroimage 2016; 131:162-70N

Abstract

The hippocampus has been shown to demonstrate a remarkable degree of plasticity in response to a variety of tasks and experiences. For example, the size of the human hippocampus has been shown to increase in response to aerobic exercise. However, it is currently unknown what underlies these changes. Here we scanned sedentary, young to middle-aged human adults before and after a six-week exercise intervention using nine different neuroimaging measures of brain structure, vasculature, and diffusion. We then tested two different hypotheses regarding the nature of the underlying changes in the tissue. Surprisingly, we found no evidence of a vascular change as has been previously reported. Rather, the pattern of changes is better explained by an increase in myelination. Finally, we show that hippocampal volume increase is temporary, returning to baseline after an additional six weeks without aerobic exercise. This is the first demonstration of a change in hippocampal volume in early to middle adulthood suggesting that hippocampal volume is modulated by aerobic exercise throughout the lifespan rather than only in the presence of age related atrophy. It is also the first demonstration of hippocampal volume change over a period of only six weeks, suggesting that gross morphometric hippocampal plasticity occurs faster than previously thought.

Authors+Show Affiliations

Section on Functional Imaging Methods, NIMH, NIH, DHHS, Bethesda, MD, USA; FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Electronic address: adamt@nih.gov.FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.Movement Sciences Group, Oxford Brookes University, Oxford, United Kingdom.Center for Neuroimaging Sciences, King's College London, London, ON, Canada.FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.Department of Statistics, University of Warwick, Coventry, United Kingdom.Department of Statistics, University of Warwick, Coventry, United Kingdom.Section on Functional Imaging Methods, NIMH, NIH, DHHS, Bethesda, MD, USA.FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26654786

Citation

Thomas, Adam G., et al. "Multi-modal Characterization of Rapid Anterior Hippocampal Volume Increase Associated With Aerobic Exercise." NeuroImage, vol. 131, 2016, pp. 162-70.
Thomas AG, Dennis A, Rawlings NB, et al. Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. Neuroimage. 2016;131:162-70.
Thomas, A. G., Dennis, A., Rawlings, N. B., Stagg, C. J., Matthews, L., Morris, M., ... Johansen-Berg, H. (2016). Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. NeuroImage, 131, pp. 162-70. doi:10.1016/j.neuroimage.2015.10.090.
Thomas AG, et al. Multi-modal Characterization of Rapid Anterior Hippocampal Volume Increase Associated With Aerobic Exercise. Neuroimage. 2016 05 1;131:162-70. PubMed PMID: 26654786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise. AU - Thomas,Adam G, AU - Dennis,Andrea, AU - Rawlings,Nancy B, AU - Stagg,Charlotte J, AU - Matthews,Lucy, AU - Morris,Martyn, AU - Kolind,Shannon H, AU - Foxley,Sean, AU - Jenkinson,Mark, AU - Nichols,Thomas E, AU - Dawes,Helen, AU - Bandettini,Peter A, AU - Johansen-Berg,Heidi, Y1 - 2015/12/02/ PY - 2015/05/19/received PY - 2015/09/30/revised PY - 2015/10/31/accepted PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2018/1/9/medline KW - Aging KW - Angiogenesis KW - Dentate gyrus KW - Environmental enrichment KW - Exercise KW - Fitness KW - Hippocampus KW - Myelin KW - Neurogenesis KW - Plasticity SP - 162 EP - 70 JF - NeuroImage JO - Neuroimage VL - 131 N2 - The hippocampus has been shown to demonstrate a remarkable degree of plasticity in response to a variety of tasks and experiences. For example, the size of the human hippocampus has been shown to increase in response to aerobic exercise. However, it is currently unknown what underlies these changes. Here we scanned sedentary, young to middle-aged human adults before and after a six-week exercise intervention using nine different neuroimaging measures of brain structure, vasculature, and diffusion. We then tested two different hypotheses regarding the nature of the underlying changes in the tissue. Surprisingly, we found no evidence of a vascular change as has been previously reported. Rather, the pattern of changes is better explained by an increase in myelination. Finally, we show that hippocampal volume increase is temporary, returning to baseline after an additional six weeks without aerobic exercise. This is the first demonstration of a change in hippocampal volume in early to middle adulthood suggesting that hippocampal volume is modulated by aerobic exercise throughout the lifespan rather than only in the presence of age related atrophy. It is also the first demonstration of hippocampal volume change over a period of only six weeks, suggesting that gross morphometric hippocampal plasticity occurs faster than previously thought. SN - 1095-9572 UR - https://www.unboundmedicine.com/medline/citation/26654786/Multi_modal_characterization_of_rapid_anterior_hippocampal_volume_increase_associated_with_aerobic_exercise_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1053-8119(15)01072-1 DB - PRIME DP - Unbound Medicine ER -