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Salivary levels of calcium, phosphorus, potassium, albumin and correlation with serum biomarkers in hemodialysis patients.
Arch Oral Biol. 2016 Feb; 62:58-63.AO

Abstract

OBJECTIVES

Evidences suggest that hemodialysis patients have reduced salivary flow and changes in the composition of salivary secretion. These changes may reflect local and systemic disorders. The objectives of this study were to compare the salivary levels of calcium (Ca), phosphorus (P), potassium (K) and albumin in hemodialysis patients and healthy subjects, and to investigate a possible correlation between their serum and salivary levels.

DESIGN

A case-control study was conducted with 60 hemodialysis patients (HD group) and 37 systemically healthy individuals (control group). Stimulated saliva samples were collected for biochemical analysis (Ca, P, K and albumin). Serum data were collected in the HD group. Statistical analysis included t-test, Pearson correlation and simple linear regression.

RESULTS

The HD group exhibited higher salivary levels of Ca, P, and albumin (p<0.05). There was a significant positive correlation between serum PTH and salivary phosphorus (r=0.342, p=0.009), and between serum PTH and salivary potassium (r=0.306, p=0.020). An increase of 100 pg/dL in serum PTH was associated with an elevation of salivary P levels (0.34 mg/dL, p=0.009), and salivary K levels (0.20 mmol/dL, p=0.02), in the HD group.

CONCLUSIONS

The findings suggest that HD patients present increased levels of salivary components (Ca, P, and albumin), and changes commonly observed in HD patients, such as hyperparathyroidism, appear to have an influence on salivary composition.

Authors+Show Affiliations

Dentistry Graduate Program, Federal University of Maranhão, São Luís, Maranhão, Brazil; Department of Morphology, Federal University of Maranhão, São Luís, Maranhão, Brazil. Electronic address: vandilson@hotmail.com.Dentistry Graduate Program, Federal University of Maranhão, São Luís, Maranhão, Brazil.Dentistry Graduate Program, Federal University of Maranhão, São Luís, Maranhão, Brazil; School of Medicine, Federal University of Maranhão, São Luís, Maranhão, Brazil.School of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.School of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.School of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.School of Dentistry, Federal University of Maranhão, São Luís, Maranhão, Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26655748

Citation

Rodrigues, Vandilson P., et al. "Salivary Levels of Calcium, Phosphorus, Potassium, Albumin and Correlation With Serum Biomarkers in Hemodialysis Patients." Archives of Oral Biology, vol. 62, 2016, pp. 58-63.
Rodrigues VP, Franco MM, Marques CP, et al. Salivary levels of calcium, phosphorus, potassium, albumin and correlation with serum biomarkers in hemodialysis patients. Arch Oral Biol. 2016;62:58-63.
Rodrigues, V. P., Franco, M. M., Marques, C. P., de Carvalho, R. C., Leite, S. A., Pereira, A. L., & Benatti, B. B. (2016). Salivary levels of calcium, phosphorus, potassium, albumin and correlation with serum biomarkers in hemodialysis patients. Archives of Oral Biology, 62, 58-63. https://doi.org/10.1016/j.archoralbio.2015.11.016
Rodrigues VP, et al. Salivary Levels of Calcium, Phosphorus, Potassium, Albumin and Correlation With Serum Biomarkers in Hemodialysis Patients. Arch Oral Biol. 2016;62:58-63. PubMed PMID: 26655748.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary levels of calcium, phosphorus, potassium, albumin and correlation with serum biomarkers in hemodialysis patients. AU - Rodrigues,Vandilson P, AU - Franco,Mayra M, AU - Marques,Consuelo P C, AU - de Carvalho,Rosana C C, AU - Leite,Sandra A M, AU - Pereira,Antonio L A, AU - Benatti,Bruno B, Y1 - 2015/11/24/ PY - 2015/06/18/received PY - 2015/10/15/revised PY - 2015/11/19/accepted PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2016/11/12/medline KW - Biochemistry KW - Biomarkers KW - Phosphorus KW - Renal Dialysis KW - Saliva SP - 58 EP - 63 JF - Archives of oral biology JO - Arch Oral Biol VL - 62 N2 - OBJECTIVES: Evidences suggest that hemodialysis patients have reduced salivary flow and changes in the composition of salivary secretion. These changes may reflect local and systemic disorders. The objectives of this study were to compare the salivary levels of calcium (Ca), phosphorus (P), potassium (K) and albumin in hemodialysis patients and healthy subjects, and to investigate a possible correlation between their serum and salivary levels. DESIGN: A case-control study was conducted with 60 hemodialysis patients (HD group) and 37 systemically healthy individuals (control group). Stimulated saliva samples were collected for biochemical analysis (Ca, P, K and albumin). Serum data were collected in the HD group. Statistical analysis included t-test, Pearson correlation and simple linear regression. RESULTS: The HD group exhibited higher salivary levels of Ca, P, and albumin (p<0.05). There was a significant positive correlation between serum PTH and salivary phosphorus (r=0.342, p=0.009), and between serum PTH and salivary potassium (r=0.306, p=0.020). An increase of 100 pg/dL in serum PTH was associated with an elevation of salivary P levels (0.34 mg/dL, p=0.009), and salivary K levels (0.20 mmol/dL, p=0.02), in the HD group. CONCLUSIONS: The findings suggest that HD patients present increased levels of salivary components (Ca, P, and albumin), and changes commonly observed in HD patients, such as hyperparathyroidism, appear to have an influence on salivary composition. SN - 1879-1506 UR - https://www.unboundmedicine.com/medline/citation/26655748/Salivary_levels_of_calcium_phosphorus_potassium_albumin_and_correlation_with_serum_biomarkers_in_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(15)30088-1 DB - PRIME DP - Unbound Medicine ER -