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Early indices of deviance detection in humans and animal models.
Biol Psychol. 2016 Apr; 116:23-7.BP

Abstract

Detecting unexpected stimuli in the environment is a critical function of the auditory system. Responses to unexpected "deviant" sounds are enhanced compared to responses to expected stimuli. At the human scalp, deviance detection is reflected in the mismatch negativity (MMN) and in an enhancement of the middle-latency response (MLR). Single neurons often respond more strongly to a stimulus when rare than when common, a phenomenon termed stimulus-specific adaptation (SSA). Here we compare stimulus-specific adaptation with scalp-recorded deviance-related responses. We conclude that early markers of deviance detection in the time range of the MLR could be a direct correlate of cortical SSA. Both occur at an early level of cortical activation, both are robust findings with low-probability stimuli, and both show properties of genuine deviance detection. Their causal relation with the later scalp-recorded MMN is a key question in this field.

Authors+Show Affiliations

Cognitive and Biological Psychology, Institute of Psychology, University of Leipzig, Leipzig, Germany. Electronic address: sabine.grimm@uni-leipzig.de.Institute for Brain, Cognition and Behavior (IR3C), University of Barcelona, Barcelona, Catalonia, Spain; Brainlab-Cognitive Neuroscience Research Group, Department of Psychiatry and Clinical Psychobiology, University of Barcelona, Barcelona, Catalonia, Spain.Department of Neurobiology, The Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel; The Edmond and Lily Safra Center for Brain Sciences, Hebrew University, Jerusalem, Israel.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26656286

Citation

Grimm, Sabine, et al. "Early Indices of Deviance Detection in Humans and Animal Models." Biological Psychology, vol. 116, 2016, pp. 23-7.
Grimm S, Escera C, Nelken I. Early indices of deviance detection in humans and animal models. Biol Psychol. 2016;116:23-7.
Grimm, S., Escera, C., & Nelken, I. (2016). Early indices of deviance detection in humans and animal models. Biological Psychology, 116, 23-7. https://doi.org/10.1016/j.biopsycho.2015.11.017
Grimm S, Escera C, Nelken I. Early Indices of Deviance Detection in Humans and Animal Models. Biol Psychol. 2016;116:23-7. PubMed PMID: 26656286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early indices of deviance detection in humans and animal models. AU - Grimm,Sabine, AU - Escera,Carles, AU - Nelken,Israel, Y1 - 2015/12/02/ PY - 2015/05/22/received PY - 2015/11/30/revised PY - 2015/11/30/accepted PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2016/12/15/medline KW - Animal models KW - Deviance detection KW - Middle latency response KW - Mismatch negativity KW - Stimulus-specific adaptation SP - 23 EP - 7 JF - Biological psychology JO - Biol Psychol VL - 116 N2 - Detecting unexpected stimuli in the environment is a critical function of the auditory system. Responses to unexpected "deviant" sounds are enhanced compared to responses to expected stimuli. At the human scalp, deviance detection is reflected in the mismatch negativity (MMN) and in an enhancement of the middle-latency response (MLR). Single neurons often respond more strongly to a stimulus when rare than when common, a phenomenon termed stimulus-specific adaptation (SSA). Here we compare stimulus-specific adaptation with scalp-recorded deviance-related responses. We conclude that early markers of deviance detection in the time range of the MLR could be a direct correlate of cortical SSA. Both occur at an early level of cortical activation, both are robust findings with low-probability stimuli, and both show properties of genuine deviance detection. Their causal relation with the later scalp-recorded MMN is a key question in this field. SN - 1873-6246 UR - https://www.unboundmedicine.com/medline/citation/26656286/Early_indices_of_deviance_detection_in_humans_and_animal_models_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-0511(15)30092-2 DB - PRIME DP - Unbound Medicine ER -