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Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study.
Sci Rep 2015; 5:18069SR

Abstract

A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is due to neurotoxic effects of psychosis. The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in patients with first-episode SZ (FES). A total of 28 FES patients and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES patients. However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because neurodevelopmental disturbances result in neurocognitive deficits long before psychotic symptoms onset.

Authors+Show Affiliations

Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. Department of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan.Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan.Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. Department of Social Work and Child Welfare, Providence University, Taichung, Taiwan.Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan.Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. Brain Connectivity Lab, Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan. Institute of Brain Science, National Yang-Ming University, Taipei, Taiwan.Department of Social Work and Child Welfare, Providence University, Taichung, Taiwan. Brain Connectivity Lab, Institute of Neuroscience, National Yang-Ming University, Taipei, Taiwan.Department of Psychiatry, Taichung Veterans General Hospital, Taichung, Taiwan. Department of Psychiatry, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan.Department of Psychiatry, Conde S. Januário General Hospital, Macau, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26656662

Citation

Chou, Po-Han, et al. "Duration of Untreated Psychosis and Brain Function During Verbal Fluency Testing in First-Episode Schizophrenia: a Near-Infrared Spectroscopy Study." Scientific Reports, vol. 5, 2015, p. 18069.
Chou PH, Lin WH, Lin CC, et al. Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study. Sci Rep. 2015;5:18069.
Chou, P. H., Lin, W. H., Lin, C. C., Hou, P. H., Li, W. R., Hung, C. C., ... Chan, C. H. (2015). Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study. Scientific Reports, 5, p. 18069. doi:10.1038/srep18069.
Chou PH, et al. Duration of Untreated Psychosis and Brain Function During Verbal Fluency Testing in First-Episode Schizophrenia: a Near-Infrared Spectroscopy Study. Sci Rep. 2015 Dec 10;5:18069. PubMed PMID: 26656662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study. AU - Chou,Po-Han, AU - Lin,Wei-Hao, AU - Lin,Chih-Chien, AU - Hou,Po-Hsun, AU - Li,Wan-Rung, AU - Hung,Chia-Chun, AU - Lin,Ching-Po, AU - Lan,Tsuo-Hung, AU - Chan,Chin-Hong, Y1 - 2015/12/10/ PY - 2015/07/23/received PY - 2015/11/09/accepted PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2016/11/8/medline SP - 18069 EP - 18069 JF - Scientific reports JO - Sci Rep VL - 5 N2 - A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is due to neurotoxic effects of psychosis. The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in patients with first-episode SZ (FES). A total of 28 FES patients and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES patients. However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because neurodevelopmental disturbances result in neurocognitive deficits long before psychotic symptoms onset. SN - 2045-2322 UR - https://www.unboundmedicine.com/medline/citation/26656662/Duration_of_Untreated_Psychosis_and_Brain_Function_during_Verbal_Fluency_Testing_in_First_Episode_Schizophrenia:_A_Near_Infrared_Spectroscopy_Study_ L2 - http://dx.doi.org/10.1038/srep18069 DB - PRIME DP - Unbound Medicine ER -