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Enantioseparation of Six Antihistamines with Immobilized Cellulose Chiral Stationary Phase by HPLC.
J Chromatogr Sci. 2016 Apr; 54(4):531-5.JC

Abstract

A stereoselective high performance liquid chromatography method has been developed for the chiral separation of the enantiomers of six antihistamines, doxylamine, carbinoxamine, dioxopromethazine, oxomemazine, cetirizine and hydroxyzine. The effects of mobile phase additive, column temperature and flow rate on the retention time and resolution were studied. Enantiomeric separation of cetirizine, doxylamine and hydroxyzine were achieved on cellulose tris-(3,5-dichlorophenylcarbamate) immobilized on silica gel chiral stationary phase known as Chiralpak IC (RS = 3.74, RS = 1.85 and RS = 1.74, respectively).

Authors+Show Affiliations

School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan 450001, P.R. China jie_0822@163.com.School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.School of Pharmacy, Zhengzhou University, Zhengzhou, Henan 450001, P.R. China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26657408

Citation

Zhou, Jie, et al. "Enantioseparation of Six Antihistamines With Immobilized Cellulose Chiral Stationary Phase By HPLC." Journal of Chromatographic Science, vol. 54, no. 4, 2016, pp. 531-5.
Zhou J, Luo P, Chen S, et al. Enantioseparation of Six Antihistamines with Immobilized Cellulose Chiral Stationary Phase by HPLC. J Chromatogr Sci. 2016;54(4):531-5.
Zhou, J., Luo, P., Chen, S., Meng, L., Sun, C., Du, Q., & Sun, F. (2016). Enantioseparation of Six Antihistamines with Immobilized Cellulose Chiral Stationary Phase by HPLC. Journal of Chromatographic Science, 54(4), 531-5. https://doi.org/10.1093/chromsci/bmv177
Zhou J, et al. Enantioseparation of Six Antihistamines With Immobilized Cellulose Chiral Stationary Phase By HPLC. J Chromatogr Sci. 2016;54(4):531-5. PubMed PMID: 26657408.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Enantioseparation of Six Antihistamines with Immobilized Cellulose Chiral Stationary Phase by HPLC. AU - Zhou,Jie, AU - Luo,Pei, AU - Chen,Shanshan, AU - Meng,Lingchang, AU - Sun,Chong, AU - Du,Qiuzheng, AU - Sun,Fang, Y1 - 2015/12/10/ PY - 2015/08/24/received PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2016/11/15/medline SP - 531 EP - 5 JF - Journal of chromatographic science JO - J Chromatogr Sci VL - 54 IS - 4 N2 - A stereoselective high performance liquid chromatography method has been developed for the chiral separation of the enantiomers of six antihistamines, doxylamine, carbinoxamine, dioxopromethazine, oxomemazine, cetirizine and hydroxyzine. The effects of mobile phase additive, column temperature and flow rate on the retention time and resolution were studied. Enantiomeric separation of cetirizine, doxylamine and hydroxyzine were achieved on cellulose tris-(3,5-dichlorophenylcarbamate) immobilized on silica gel chiral stationary phase known as Chiralpak IC (RS = 3.74, RS = 1.85 and RS = 1.74, respectively). SN - 1945-239X UR - https://www.unboundmedicine.com/medline/citation/26657408/Enantioseparation_of_Six_Antihistamines_with_Immobilized_Cellulose_Chiral_Stationary_Phase_by_HPLC_ L2 - https://academic.oup.com/chromsci/article-lookup/doi/10.1093/chromsci/bmv177 DB - PRIME DP - Unbound Medicine ER -