Tags

Type your tag names separated by a space and hit enter

Ameliorative effect of lotus seedpod proanthocyanidins on cognitive impairment and brain aging induced by D-galactose.
Exp Gerontol. 2016 Feb; 74:21-8.EG

Abstract

This study mainly investigated the ameliorative effect of lotus seedpod proanthocyanidins (LSPC) and the mechanism underlying such effect on cognitive impairment and brain aging induced by d-galactose. Aging mice induced by d-galactose (150 mg/kg, sc injection daily for 6 weeks) were chosen for the experiment. LSPCs (30, 60, and 90 mg/kg, ig) were provided after d-galactose injection. Learning and memory functions were detected by Y-maze and step-down avoidance tests. Then, some biochemical indexes related to cognitive ability and aging were measured. Histopathological feature and P53 protein expression in the hippocampus were observed. Results showed that the three different doses of LSPC could significantly ameliorate the learning and memory abilities impaired by d-galactose. LSPC significantly reduced the levels of malondialdehyde and nitric oxide (i.e. 90 mg/kg LSPC group vs. model group, P=0.008), reduced the content of β-amyloid peptide 1-42 (i.e. 90 mg/kg LSPC group vs. model group, P=0.009), decreased the activities of acetylcholinesterase, monoamine oxidase B, total nitric oxide synthase (i.e. 90 mg/kg LSPC group vs. model group, P=0.006), and neuronal nitric oxide synthase and synchronously increased the activities of superoxide dismutase and glutathione peroxidase in the brain. Furthermore, LSPC could prevent neuron damage and could lessen the expression of P53 protein in the hippocampus. These findings demonstrated that LSPC effectively attenuated cognitive damage and improved parameters related to brain aging in senescent mice induced by d-galactose, and may be used to treat Alzheimer's disease.

Authors+Show Affiliations

School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China. Electronic address: tortoise39@163.com.School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China.School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China.School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China.Natural Product Laboratory, Food Science and Technology Department, Huazhong Agriculture University, Wuhan 430070, China. Electronic address: bijunxie@mail.hzau.edu.cn.Natural Product Laboratory, Food Science and Technology Department, Huazhong Agriculture University, Wuhan 430070, China.Natural Product Laboratory, Food Science and Technology Department, Huazhong Agriculture University, Wuhan 430070, China.School of Food Science, Guangdong Pharmaceutical University, Zhongshan 528458, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26657492

Citation

Gong, Yu-Shi, et al. "Ameliorative Effect of Lotus Seedpod Proanthocyanidins On Cognitive Impairment and Brain Aging Induced By D-galactose." Experimental Gerontology, vol. 74, 2016, pp. 21-8.
Gong YS, Guo J, Hu K, et al. Ameliorative effect of lotus seedpod proanthocyanidins on cognitive impairment and brain aging induced by D-galactose. Exp Gerontol. 2016;74:21-8.
Gong, Y. S., Guo, J., Hu, K., Gao, Y. Q., Xie, B. J., Sun, Z. D., Yang, E. N., & Hou, F. L. (2016). Ameliorative effect of lotus seedpod proanthocyanidins on cognitive impairment and brain aging induced by D-galactose. Experimental Gerontology, 74, 21-8. https://doi.org/10.1016/j.exger.2015.11.020
Gong YS, et al. Ameliorative Effect of Lotus Seedpod Proanthocyanidins On Cognitive Impairment and Brain Aging Induced By D-galactose. Exp Gerontol. 2016;74:21-8. PubMed PMID: 26657492.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ameliorative effect of lotus seedpod proanthocyanidins on cognitive impairment and brain aging induced by D-galactose. AU - Gong,Yu-Shi, AU - Guo,Juan, AU - Hu,Kun, AU - Gao,Yong-Qing, AU - Xie,Bi-Jun, AU - Sun,Zhi-Da, AU - Yang,Er-Ning, AU - Hou,Fang-Li, Y1 - 2015/11/30/ PY - 2015/06/01/received PY - 2015/11/10/revised PY - 2015/11/30/accepted PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2016/11/12/medline KW - Brain aging KW - Free radicals KW - Learning and memory KW - Lotus seedpod proanthocyanidins KW - d-Galactose SP - 21 EP - 8 JF - Experimental gerontology JO - Exp Gerontol VL - 74 N2 - This study mainly investigated the ameliorative effect of lotus seedpod proanthocyanidins (LSPC) and the mechanism underlying such effect on cognitive impairment and brain aging induced by d-galactose. Aging mice induced by d-galactose (150 mg/kg, sc injection daily for 6 weeks) were chosen for the experiment. LSPCs (30, 60, and 90 mg/kg, ig) were provided after d-galactose injection. Learning and memory functions were detected by Y-maze and step-down avoidance tests. Then, some biochemical indexes related to cognitive ability and aging were measured. Histopathological feature and P53 protein expression in the hippocampus were observed. Results showed that the three different doses of LSPC could significantly ameliorate the learning and memory abilities impaired by d-galactose. LSPC significantly reduced the levels of malondialdehyde and nitric oxide (i.e. 90 mg/kg LSPC group vs. model group, P=0.008), reduced the content of β-amyloid peptide 1-42 (i.e. 90 mg/kg LSPC group vs. model group, P=0.009), decreased the activities of acetylcholinesterase, monoamine oxidase B, total nitric oxide synthase (i.e. 90 mg/kg LSPC group vs. model group, P=0.006), and neuronal nitric oxide synthase and synchronously increased the activities of superoxide dismutase and glutathione peroxidase in the brain. Furthermore, LSPC could prevent neuron damage and could lessen the expression of P53 protein in the hippocampus. These findings demonstrated that LSPC effectively attenuated cognitive damage and improved parameters related to brain aging in senescent mice induced by d-galactose, and may be used to treat Alzheimer's disease. SN - 1873-6815 UR - https://www.unboundmedicine.com/medline/citation/26657492/Ameliorative_effect_of_lotus_seedpod_proanthocyanidins_on_cognitive_impairment_and_brain_aging_induced_by_D_galactose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0531-5565(15)30098-X DB - PRIME DP - Unbound Medicine ER -