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The role of insulin in the vascular contributions to age-related dementia.
Biochim Biophys Acta 2016; 1862(5):983-91BB

Abstract

In addition to its well-known role in energy metabolism in the body, insulin is a vasoactive hormone that regulates peripheral and cerebral blood flow and neuronal function. Vascular and metabolic dysfunctions are emerging risk factors for Alzheimer's disease (AD) and age-related dementias, and recent evidence suggests that the two pathways are constitutive and interrelated. As a result, an emphasis on correcting metabolic disorders is emerging as an important strategy in the treatment and prevention of age-related cognitive impairment and AD. We review the evidence regarding the unique and interactive effects of vascular and metabolic disorders in pathological brain aging, with special consideration of the role of insulin dysregulation in promoting AD pathologic processes and vascular brain injury. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock.

Authors+Show Affiliations

Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Wake Forest University, USA.Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Wake Forest University, USA. Electronic address: suzcraft@wakehealth.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26657615

Citation

Hughes, Timothy M., and Suzanne Craft. "The Role of Insulin in the Vascular Contributions to Age-related Dementia." Biochimica Et Biophysica Acta, vol. 1862, no. 5, 2016, pp. 983-91.
Hughes TM, Craft S. The role of insulin in the vascular contributions to age-related dementia. Biochim Biophys Acta. 2016;1862(5):983-91.
Hughes, T. M., & Craft, S. (2016). The role of insulin in the vascular contributions to age-related dementia. Biochimica Et Biophysica Acta, 1862(5), pp. 983-91. doi:10.1016/j.bbadis.2015.11.013.
Hughes TM, Craft S. The Role of Insulin in the Vascular Contributions to Age-related Dementia. Biochim Biophys Acta. 2016;1862(5):983-91. PubMed PMID: 26657615.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of insulin in the vascular contributions to age-related dementia. AU - Hughes,Timothy M, AU - Craft,Suzanne, Y1 - 2015/12/02/ PY - 2015/09/01/received PY - 2015/11/17/revised PY - 2015/11/29/accepted PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2019/1/25/medline KW - Alzheimer's disease KW - Brain KW - Glucose KW - Insulin KW - Metabolism KW - Vascular SP - 983 EP - 91 JF - Biochimica et biophysica acta JO - Biochim. Biophys. Acta VL - 1862 IS - 5 N2 - In addition to its well-known role in energy metabolism in the body, insulin is a vasoactive hormone that regulates peripheral and cerebral blood flow and neuronal function. Vascular and metabolic dysfunctions are emerging risk factors for Alzheimer's disease (AD) and age-related dementias, and recent evidence suggests that the two pathways are constitutive and interrelated. As a result, an emphasis on correcting metabolic disorders is emerging as an important strategy in the treatment and prevention of age-related cognitive impairment and AD. We review the evidence regarding the unique and interactive effects of vascular and metabolic disorders in pathological brain aging, with special consideration of the role of insulin dysregulation in promoting AD pathologic processes and vascular brain injury. This article is part of a Special Issue entitled: Vascular Contributions to Cognitive Impairment and Dementia edited by M. Paul Murphy, Roderick A. Corriveau and Donna M. Wilcock. SN - 0006-3002 UR - https://www.unboundmedicine.com/medline/citation/26657615/The_role_of_insulin_in_the_vascular_contributions_to_age_related_dementia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0925-4439(15)00352-X DB - PRIME DP - Unbound Medicine ER -