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HLA B27 and ankylosing spondylitis: a population and family study in Sardinia.
J Rheumatol Suppl. 1977; 3:18-23.JR

Abstract

Thirty-eight patients with ankylosing spondylitis (AS) and 494 unrelated controls in Sardinia were HLA Typed. HLA B27 was present in 81.8 per cent of AS vs 5.3 per cent of controls (relative risk: 80). Twenty-six apparently healthy B27 positive individuals were studied clinically and radiologically, and six (23.0 per cent) presented signs of definite or suspicious AS. A family study on relatives of seven AS B27-positive and four AS B27-negative patients was also made. The results suggest a dominant heredity of AS susceptibility, and are compatible with a direct involvement of the B27 antigen in the mechanism of AS, but we cannot rule out a closely linked disease-susceptibility gene with incomplete penetrance.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

266592

Citation

Contu, L, et al. "HLA B27 and Ankylosing Spondylitis: a Population and Family Study in Sardinia." The Journal of Rheumatology. Supplement, vol. 3, 1977, pp. 18-23.
Contu L, Capelli P, Sale S. HLA B27 and ankylosing spondylitis: a population and family study in Sardinia. J Rheumatol Suppl. 1977;3:18-23.
Contu, L., Capelli, P., & Sale, S. (1977). HLA B27 and ankylosing spondylitis: a population and family study in Sardinia. The Journal of Rheumatology. Supplement, 3, 18-23.
Contu L, Capelli P, Sale S. HLA B27 and Ankylosing Spondylitis: a Population and Family Study in Sardinia. J Rheumatol Suppl. 1977;3:18-23. PubMed PMID: 266592.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HLA B27 and ankylosing spondylitis: a population and family study in Sardinia. AU - Contu,L, AU - Capelli,P, AU - Sale,S, PY - 1977/1/1/pubmed PY - 1977/1/1/medline PY - 1977/1/1/entrez SP - 18 EP - 23 JF - The Journal of rheumatology. Supplement JO - J Rheumatol Suppl VL - 3 N2 - Thirty-eight patients with ankylosing spondylitis (AS) and 494 unrelated controls in Sardinia were HLA Typed. HLA B27 was present in 81.8 per cent of AS vs 5.3 per cent of controls (relative risk: 80). Twenty-six apparently healthy B27 positive individuals were studied clinically and radiologically, and six (23.0 per cent) presented signs of definite or suspicious AS. A family study on relatives of seven AS B27-positive and four AS B27-negative patients was also made. The results suggest a dominant heredity of AS susceptibility, and are compatible with a direct involvement of the B27 antigen in the mechanism of AS, but we cannot rule out a closely linked disease-susceptibility gene with incomplete penetrance. SN - 0380-0903 UR - https://www.unboundmedicine.com/medline/citation/266592/HLA_B27_and_ankylosing_spondylitis:_a_population_and_family_study_in_Sardinia_ L2 - https://www.diseaseinfosearch.org/result/9679 DB - PRIME DP - Unbound Medicine ER -