Tags

Type your tag names separated by a space and hit enter

An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish.
J Comp Physiol B. 2016 Feb; 186(2):145-59.JC

Abstract

Three gases comprising nitric oxide, carbon monoxide and hydrogen sulphide, collectively are termed gasotransmitters. The gasotransmitters control several physiological functions in fish by acting as intracellular signaling molecules. Hydrogen sulphide, first implicated in vasomotor control in fish, plays a critical role in oxygen chemoreception owing to its production and downstream effects within the oxygen chemosensory cells, the neuroepithelial cells. Indeed, there is emerging evidence that hydrogen sulphide may contribute to oxygen sensing in both fish and mammals by promoting membrane depolarization of the chemosensory cells. Unlike hydrogen sulphide which stimulates breathing in zebrafish, carbon monoxide inhibits ventilation in goldfish and zebrafish whereas nitric oxide stimulates breathing in zebrafish larvae while inhibiting breathing in adults. Gasotransmitters also modulate ionic uptake in zebrafish. Though nothing is known about the role of CO, reduced activities of branchial Na(+)/K(+)-ATPase and H(+)-ATPase activities in the presence of NO donors suggest an inhibitory role of NO in fish osmoregulation. Hydrogen sulphide inhibits Na(+) uptake in zebrafish larvae and contributes to lowering Na(+) uptake capacity in fish acclimated to Na(+)-enriched water whereas it stimulates Ca(2+) uptake in larvae exposed to Ca(2+)-poor water.

Authors+Show Affiliations

Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N6N5, Canada. sfperry@uottawa.ca.Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N6N5, Canada.Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N6N5, Canada. Biosciences, College of Life and Environmental Sciences, University of Exeter, Exeter, EX4 4QD, UK.Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N6N5, Canada.Department of Biology, University of Ottawa, 30 Marie Curie, Ottawa, ON, K1N6N5, Canada.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26660653

Citation

Perry, Steve, et al. "An Emerging Role for Gasotransmitters in the Control of Breathing and Ionic Regulation in Fish." Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, vol. 186, no. 2, 2016, pp. 145-59.
Perry S, Kumai Y, Porteus CS, et al. An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish. J Comp Physiol B. 2016;186(2):145-59.
Perry, S., Kumai, Y., Porteus, C. S., Tzaneva, V., & Kwong, R. W. (2016). An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish. Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology, 186(2), 145-59. https://doi.org/10.1007/s00360-015-0949-x
Perry S, et al. An Emerging Role for Gasotransmitters in the Control of Breathing and Ionic Regulation in Fish. J Comp Physiol B. 2016;186(2):145-59. PubMed PMID: 26660653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An emerging role for gasotransmitters in the control of breathing and ionic regulation in fish. AU - Perry,Steve, AU - Kumai,Y, AU - Porteus,C S, AU - Tzaneva,V, AU - Kwong,R W M, Y1 - 2015/12/11/ PY - 2015/08/03/received PY - 2015/11/25/accepted PY - 2015/11/04/revised PY - 2015/12/15/entrez PY - 2015/12/15/pubmed PY - 2016/10/16/medline KW - Carbon monoxide KW - Chemoreception KW - Heme oxygenase KW - Hydrogen sulphide KW - Ionocyte KW - Neuroepithelial cell KW - Nitric oxide KW - Osmoregulation KW - Ventilation KW - Zebrafish SP - 145 EP - 59 JF - Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology JO - J Comp Physiol B VL - 186 IS - 2 N2 - Three gases comprising nitric oxide, carbon monoxide and hydrogen sulphide, collectively are termed gasotransmitters. The gasotransmitters control several physiological functions in fish by acting as intracellular signaling molecules. Hydrogen sulphide, first implicated in vasomotor control in fish, plays a critical role in oxygen chemoreception owing to its production and downstream effects within the oxygen chemosensory cells, the neuroepithelial cells. Indeed, there is emerging evidence that hydrogen sulphide may contribute to oxygen sensing in both fish and mammals by promoting membrane depolarization of the chemosensory cells. Unlike hydrogen sulphide which stimulates breathing in zebrafish, carbon monoxide inhibits ventilation in goldfish and zebrafish whereas nitric oxide stimulates breathing in zebrafish larvae while inhibiting breathing in adults. Gasotransmitters also modulate ionic uptake in zebrafish. Though nothing is known about the role of CO, reduced activities of branchial Na(+)/K(+)-ATPase and H(+)-ATPase activities in the presence of NO donors suggest an inhibitory role of NO in fish osmoregulation. Hydrogen sulphide inhibits Na(+) uptake in zebrafish larvae and contributes to lowering Na(+) uptake capacity in fish acclimated to Na(+)-enriched water whereas it stimulates Ca(2+) uptake in larvae exposed to Ca(2+)-poor water. SN - 1432-136X UR - https://www.unboundmedicine.com/medline/citation/26660653/An_emerging_role_for_gasotransmitters_in_the_control_of_breathing_and_ionic_regulation_in_fish_ L2 - http://dx.doi.org/10.1007/s00360-015-0949-x DB - PRIME DP - Unbound Medicine ER -